Yingjie Xu
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View article: Nano-therapeutics targeting the macrophage-based microenvironment in the treatment of atherosclerosis
Nano-therapeutics targeting the macrophage-based microenvironment in the treatment of atherosclerosis Open
Atherosclerosis (AS) is a chronic inflammatory disease that primarily affects large and medium-sized arteries and serves as the major pathological basis for cardiovascular diseases such as coronary heart disease. During the progression of …
View article: Research Progress on Optimal Blending of Iron Ore Powders for Sintering
Research Progress on Optimal Blending of Iron Ore Powders for Sintering Open
View article: Research on Sliding-Window Batch Processing Orbit Determination Algorithm for Satellite-to-Satellite Tracking
Research on Sliding-Window Batch Processing Orbit Determination Algorithm for Satellite-to-Satellite Tracking Open
In response to the increasing demand for high-precision navigation of satellites operating in the cislunar space, this study introduces an onboard orbit determination algorithm considering both convergence and computational efficiency, ref…
View article: Psoralen-mediated regulation of osteogenic differentiation of periodontal ligament stem cells: involvement of the mTOR pathway
Psoralen-mediated regulation of osteogenic differentiation of periodontal ligament stem cells: involvement of the mTOR pathway Open
Background Chronic periodontitis is a prevalent inflammatory and destructive oral disease, and its primary treatment is to control the development of inflammation and promote the regeneration of periodontal tissue. Psoralen (Pso) has been …
View article: FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis
FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis Open
View article: Nanoparticle delivery of VEGF-B mRNA promotes T cell infiltration within tumor and triggers robust antitumor immunity
Nanoparticle delivery of VEGF-B mRNA promotes T cell infiltration within tumor and triggers robust antitumor immunity Open
The advancement of mRNA-based cancer immunotherapies has gained significant momentum, particularly after the success of mRNA vaccines during the COVID-19 pandemic and the recognition of mRNA vaccine development with the 2023 Nobel Prize. m…
View article: Autonomous Orbit Determination of LLO Satellite Using DRO–LLO Links and Lunar Laser Ranging
Autonomous Orbit Determination of LLO Satellite Using DRO–LLO Links and Lunar Laser Ranging Open
A stable and high-precision autonomous orbit determination scheme for a Low Lunar Orbit (LLO) spacecraft is proposed, leveraging satellite-to-satellite tracking (SST) measurement data and lunar laser ranging data. One satellite orbits arou…
View article: Identification of VOC emission hotspots in industrial parks by high-spatiotemporal-resolution sensor networks
Identification of VOC emission hotspots in industrial parks by high-spatiotemporal-resolution sensor networks Open
View article: Codelivery of NGFR100W and VEGFA mRNA Enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy
Codelivery of NGFR100W and VEGFA mRNA Enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy Open
Diabetic peripheral neuropathy (DPN) poses significant clinical challenges due to progressive nerve degeneration and vascular insufficiency. To address both neural and vascular complications simultaneously, we employed an mRNA-based protei…
View article: Co-Delivery of NGF<sup>R100W</sup> and VEGFA mRNA enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy
Co-Delivery of NGF<sup>R100W</sup> and VEGFA mRNA enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy Open
Diabetic peripheral neuropathy (DPN) poses significant clinical challenges due to progressive nerve degeneration and vascular insufficiency. To address both neural and vascular complications simultaneously, we employed a messenger RNA (mRN…
View article: Co-Delivery of NGF<sup>R100W</sup> and VEGFA mRNA enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy
Co-Delivery of NGF<sup>R100W</sup> and VEGFA mRNA enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy Open
Diabetic peripheral neuropathy (DPN) poses significant clinical challenges due to progressive nerve degeneration and vascular insufficiency. To address both neural and vascular complications simultaneously, we employed a messenger RNA (mRN…
View article: Unveiling MAGEA3: a novel predictive biomarker for bevacizumab resistance in colorectal cancer
Unveiling MAGEA3: a novel predictive biomarker for bevacizumab resistance in colorectal cancer Open
Aim: Bevacizumab has long been a cornerstone in the treatment of colorectal cancer (CRC), serving as a fundamental antiangiogenic therapeutic option. However, a significant proportion of patients exhibit insensitivity to bevacizumab, and n…
View article: Multi-omics Analysis Sheds Light on the Extracellular Role of PCMT1
Multi-omics Analysis Sheds Light on the Extracellular Role of PCMT1 Open
Proteins are constantly damaged by intracellular and extracellular factors, particularly under stress conditions, leading to an accumulation of modified proteins such as isoaspartate (isoD), which is linked to aging and various diseases. T…
View article: Clinical study of colorViz fusion image vascular grading based on multi-phase CTA reconstruction in acute ischemic stroke
Clinical study of colorViz fusion image vascular grading based on multi-phase CTA reconstruction in acute ischemic stroke Open
The mCTA ColorViz fusion images produced by FastStroke software provide valuable diagnostic insights for newly diagnosed cerebral infarction in AIS patients. The sensitivity of these images is notably higher for superficial infarctions com…
View article: Burkholderia seminalis suppresses Fusarium wilt infection in banana by modulating cell wall integrity
Burkholderia seminalis suppresses Fusarium wilt infection in banana by modulating cell wall integrity Open
View article: Cyclosporine A ameliorates ulcerative colitis by inhibiting cellular senescence, modulating the JAK2-STAT3/NF-κB signaling pathway, and regulating the gut microbiota-metabolite axis
Cyclosporine A ameliorates ulcerative colitis by inhibiting cellular senescence, modulating the JAK2-STAT3/NF-κB signaling pathway, and regulating the gut microbiota-metabolite axis Open
View article: Accurately Identifying Primary Tvoc Pollution Sources in Various Communities Via Ultra-High Spatiotemporal Resolution Sensor Networks
Accurately Identifying Primary Tvoc Pollution Sources in Various Communities Via Ultra-High Spatiotemporal Resolution Sensor Networks Open
View article: DNA methylation confers a cerebellum-specific identity in non-human primates
DNA methylation confers a cerebellum-specific identity in non-human primates Open
Selective regulation of gene expression across distinct brain regions is crucial for establishing and maintaining subdivision identities. DNA methylation, a key regulator of gene transcription, modulates transcriptional activity through th…
View article: Correction: Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition
Correction: Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition Open
View article: Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition
Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition Open
Ferroptosis is a regulated cell death process dependent on iron, triggered by the accumulation of lipid peroxidation. The environmental context significantly impacts cellular sensitivities to ferroptosis. Serum, constituting the extracellu…
View article: Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy
Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy Open
Hyperuricemia, i.e., increased plasma uric acid concentration, is a common problem in clinical practice, leading to gout or nephrolithiasis, and is associated with other disorders, such as metabolic syndrome, cardiovascular disease, and ch…
View article: mRNA‐Lipid Nanoparticle‐Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple‐Negative Breast Cancer
mRNA‐Lipid Nanoparticle‐Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple‐Negative Breast Cancer Open
Triple‐negative breast cancer (TNBC) poses a challenging prognosis due to early metastasis driven by anoikis resistance. Identifying crucial regulators to overcome this resistance is vital for improving patient outcomes. In this study, a g…
View article: Medical effectiveness and cost-effectiveness of a multidisciplinary team-based approach to the management of community residents with hypertension: an analysis of an interventional follow-up study
Medical effectiveness and cost-effectiveness of a multidisciplinary team-based approach to the management of community residents with hypertension: an analysis of an interventional follow-up study Open
Background This study assessed the medical effectiveness and cost-effectiveness of a multidisciplinary team (MDT)-based interventional follow-up in managing hypertension, thereby serving as an evidence base for decision-making in disease p…
View article: Layer-controlled fractal growth of vanadium-doped molybdenum disulfide
Layer-controlled fractal growth of vanadium-doped molybdenum disulfide Open
Vanadium doping can effectively modify the physical properties of transition metal dichalcogenides (TMDCs), broadening their application prospect in electronic, spintronic, and valleytronic devices. However, vanadium dopants always suppres…
View article: Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants
Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants Open
The global emergence of SARS-CoV-2 variants has led to increasing breakthrough infections in vaccinated populations, calling for an urgent need to develop more effective and broad-spectrum vaccines to combat COVID-19. Here we report the pr…
View article: Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer Open
View article: The Screening of Broadly Neutralizing Antibodies Targeting the SARS-CoV-2 Spike Protein by mRNA Immunization in Mice
The Screening of Broadly Neutralizing Antibodies Targeting the SARS-CoV-2 Spike Protein by mRNA Immunization in Mice Open
Neutralizing antibodies (nAbs), the popular antiviral drugs used for the treatment of COVID-19, are effective in reducing viral load and hospitalization. Currently, most nAbs are screened from convalescent or vaccinated individuals through…
View article: An integrated co-expression network analysis reveals novel genetic biomarkers for immune cell infiltration in chronic kidney disease
An integrated co-expression network analysis reveals novel genetic biomarkers for immune cell infiltration in chronic kidney disease Open
Background Chronic kidney disease (CKD) is characterized by persistent damage to kidney function or structure. Progression to end-stage leads to adverse effects on multiple systems. However, owing to its complex etiology and long-term caus…
View article: mRNA-Based Therapeutics in Cancer Treatment
mRNA-Based Therapeutics in Cancer Treatment Open
Over the past two decades, significant technological innovations have led to messenger RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic vaccines, protein replacement therapies, and genome engineering. The …
View article: Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection
Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection Open