Yanping Hu
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View article: Mycobacterial ESAT-6 triggers cGAS-STING pathway via the GSDMD-NT dependent mitochondria dysfunction
Mycobacterial ESAT-6 triggers cGAS-STING pathway via the GSDMD-NT dependent mitochondria dysfunction Open
Mycobacterium tuberculosis (Mtb) remains a global health threat due to its ability to subvert host immune responses. Emerging evidence suggests that Mtb infection induces the production of type I interferons (IFNs), du…
View article: First-Line Tislelizumab Plus Chemotherapy in Advanced Non-Squamous Non-Small Cell Lung Cancer: PD-L1 ≥ 50% Subgroup Analysis from the RATIONALE-304 Trial
First-Line Tislelizumab Plus Chemotherapy in Advanced Non-Squamous Non-Small Cell Lung Cancer: PD-L1 ≥ 50% Subgroup Analysis from the RATIONALE-304 Trial Open
Clinical Trials.gov NCT03663205.
View article: Efficient photosynthesis and economic water use of citrus leaves depend on hybrid, cultivar and leaf type
Efficient photosynthesis and economic water use of citrus leaves depend on hybrid, cultivar and leaf type Open
Efficient photosynthesis and economic water use are essential for citrus growth, development and fruit production. The present study was aimed to characterize these processes in current-year spring, autumn, summer and spring shoots of citr…
View article: Innovative diagnostic approaches for lung cancer: integrating traditional cytology with qPCR for rapid and reliable results
Innovative diagnostic approaches for lung cancer: integrating traditional cytology with qPCR for rapid and reliable results Open
View article: Clinical characteristics, clinical laboratories, and risk factors of elderly patients with chronic obstructive pulmonary disease complicated with pulmonary embolism
Clinical characteristics, clinical laboratories, and risk factors of elderly patients with chronic obstructive pulmonary disease complicated with pulmonary embolism Open
Purpose The objective of this research is to examine the occurrence, clinical manifestations, and determinants of pulmonary embolism (PE) in older individuals diagnosed with chronic obstructive pulmonary disease (COPD). Methods A retrospec…
View article: Exploring the active ingredients of Banzhilian and its mechanism of action on diabetic Gastric cancer based on network pharmacology
Exploring the active ingredients of Banzhilian and its mechanism of action on diabetic Gastric cancer based on network pharmacology Open
The incidence of Gastric cancer (GC) has shown a sharp upward trend, and patients with GC complicated by diabetes exhibit significantly worse clinical outcomes and prognosis compared to those without diabetes. Traditional Chinese medicine …
View article: <scp>CXCL</scp> Gene Clusters Regulated by Enhancer‐Mediated <scp>DNA</scp> Looping Alteration in Pancreatic Cancer Cells
<span>CXCL</span> Gene Clusters Regulated by Enhancer‐Mediated <span>DNA</span> Looping Alteration in Pancreatic Cancer Cells Open
Pancreatic cancer is one of the deadliest cancers. Chemokines affect the progression of pancreatic cancer through various mechanisms. Most of the CXC chemokine genes, CC chemokine genes and CX3C chemokine genes are clustered together withi…
View article: Efficacy and safety of finotonlimab plus docetaxel vs. docetaxel in previously treated advanced squamous cell non-small-cell lung cancer: a randomized, double-blinded, phase III trial
Efficacy and safety of finotonlimab plus docetaxel vs. docetaxel in previously treated advanced squamous cell non-small-cell lung cancer: a randomized, double-blinded, phase III trial Open
NCT04171284, ClinicalTrials.gov.
View article: Genomic analysis of 1,325 Camellia accessions sheds light on agronomic and metabolic traits for tea plant improvement
Genomic analysis of 1,325 Camellia accessions sheds light on agronomic and metabolic traits for tea plant improvement Open
View article: The role of lymph node level ratio in predicting prognosis and the benefits of postoperative radiotherapy in patients with pathological N1 stage head and neck squamous cell carcinoma
The role of lymph node level ratio in predicting prognosis and the benefits of postoperative radiotherapy in patients with pathological N1 stage head and neck squamous cell carcinoma Open
The LNLR is a more robust quality indicator for neck dissection. An LNLR of ≤ 5.25 significantly compromises survival and indicates the need for PORT in patients with pN1 HNSCC.
View article: A phase II trial of anlotinib plus EGFR-TKIs in advanced non-small cell lung cancer with gradual, oligo, or potential progression after EGFR-TKIs treatment (CTONG-1803/ALTER-L001)
A phase II trial of anlotinib plus EGFR-TKIs in advanced non-small cell lung cancer with gradual, oligo, or potential progression after EGFR-TKIs treatment (CTONG-1803/ALTER-L001) Open
NCT04007835.
View article: Effect of Capping-Temperature Control Coupled with Electroosmotic Adsorption on Sediment Phosphorus Forms and Release Characteristics
Effect of Capping-Temperature Control Coupled with Electroosmotic Adsorption on Sediment Phosphorus Forms and Release Characteristics Open
View article: A phase II trial of anlotinib plus EGFR-TKIs in advanced non-small cell lung cancer with gradual, oligo, or potential progression after EGFR-TKIs treatment (CTONG-1803/ALTER-L001)
A phase II trial of anlotinib plus EGFR-TKIs in advanced non-small cell lung cancer with gradual, oligo, or potential progression after EGFR-TKIs treatment (CTONG-1803/ALTER-L001) Open
Background: The study is to evaluate the efficacy and safety of combined anlotinib and EGFR-tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC) who had gradual, oligo, or potential progression aft…
View article: Clinicopathological correlations in 38 cases of gastroenteropancreatic high-grade neuroendocrine neoplasms
Clinicopathological correlations in 38 cases of gastroenteropancreatic high-grade neuroendocrine neoplasms Open
Objective Diagnosis and treatment of gastroenteropancreatic high-grade neuroendocrine neoplasms (GEP-HG-NENs), particularly G3 well-differentiated neuroendocrine tumours (NETs) and poorly differentiated neuroendocrine carcinomas (NECs) rel…
View article: Sodium Houttuyniae attenuates ferroptosis by regulating TRAF6-c-Myc signaling pathways in lipopolysaccharide-induced acute lung injury (ALI)
Sodium Houttuyniae attenuates ferroptosis by regulating TRAF6-c-Myc signaling pathways in lipopolysaccharide-induced acute lung injury (ALI) Open
The impact of Sodium Houttuyniae (SH) on lipopolysaccharide (LPS)-induced ALI has been investigated extensively. However, it remains ambiguous whether ferroptosis participates in this process. This study aimed to find out the impacts and p…
View article: Clinical Value of Serum Secretoneurin Levels in Prediction of Delayed Cerebral Ischemia and Prognostic Analysis of Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study
Clinical Value of Serum Secretoneurin Levels in Prediction of Delayed Cerebral Ischemia and Prognostic Analysis of Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study Open
Serum secretoneurin levels significantly increased after aSAH, which was intimately correlated with disease severity and independently associated with DCI and worse outcomes, indicating that serum secretoneurin may be a potential prognosti…
View article: Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated, <i>EGFR</i>‐mutated, advanced non‐small cell lung cancer: data from a randomized phase III trial (AENEAS)
Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated, <i>EGFR</i>‐mutated, advanced non‐small cell lung cancer: data from a randomized phase III trial (AENEAS) Open
Background The initial randomized, double‐blinded, actively controlled, phase III ANEAS study (NCT03849768) demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first‐line therapy in epidermal growth factor rece…
View article: A Prospective Longitudinal Cohort Study of Serum Stanniocalcin-1 as a Potential Prognostic Biomarker of Severe Traumatic Brain Injury
A Prospective Longitudinal Cohort Study of Serum Stanniocalcin-1 as a Potential Prognostic Biomarker of Severe Traumatic Brain Injury Open
A significant elevation of serum STC1 levels is highly related to severity and clinical outcome, suggesting that serum STC1 may be a potential prognostic biomarker of sTBI.
View article: OTULIN regulates uveal melanoma tumorigenicity by deubiquitinating IGSF11
OTULIN regulates uveal melanoma tumorigenicity by deubiquitinating IGSF11 Open
Uveal melanoma (UVM) is the most prevalent primary intraocular malignancy and is known for its poor prognosis and resistance to existing therapies. This study explores the role of OTULIN, a deubiquitinating enzyme, in the pathogenesis of U…
View article: Landscape ecological risk evaluation and prediction under a wetland conservation scenario in the Sanjiang Plain based on land use/cover change
Landscape ecological risk evaluation and prediction under a wetland conservation scenario in the Sanjiang Plain based on land use/cover change Open
Landscape ecological risk is the term used to describe potential negative effects of the relationship between environmental processes and landscape structure as a result of both natural and human interactions. The scientific assessment of …
View article: Analysis of Spatio-Temporal Evolution and Driving Factors of Eco-Environmental Quality during Highway Construction Based on RSEI
Analysis of Spatio-Temporal Evolution and Driving Factors of Eco-Environmental Quality during Highway Construction Based on RSEI Open
One essential part of transportation infrastructure is highways. The surrounding eco-environment is greatly impacted by the construction of highways. However, few studies have investigated changes in eco-environmental quality during highwa…
View article: Yields, growth and water use under chemical topping in relations to row configuration and plant density in drip-irrigated cotton
Yields, growth and water use under chemical topping in relations to row configuration and plant density in drip-irrigated cotton Open
Background Water deficit is an important problem in agricultural production in arid regions. With the advent of wholly mechanized technology for cotton planting in Xinjiang, it is important to determine which planting mode could achieve hi…
View article: Correction: Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons
Correction: Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons Open
View article: 29P Real-world safety of osimertinib in Chinese patients with non-small cell lung cancer (NSCLC)
29P Real-world safety of osimertinib in Chinese patients with non-small cell lung cancer (NSCLC) Open
The aim of this study was to better understand the real-world safety profile of osimertinib in Chinese NSCLC patients (pts). This was a prospective, observational study conducted in Chinese NSCLC pts who received ≥1 dose of osimertinib. Pt…
View article: 137MO Phase II study of becotarug (JMT101) combined with osimertinib in patients (pts) with locally advanced or metastatic NSCLC harboring EGFR exon 20 insertion (ex20ins) mutations (BECOME study)
137MO Phase II study of becotarug (JMT101) combined with osimertinib in patients (pts) with locally advanced or metastatic NSCLC harboring EGFR exon 20 insertion (ex20ins) mutations (BECOME study) Open
Pts with EGFR ex20ins positive NSCLC have limited therapeutic options and dismal prognosis. Becotarug is a humanized IgG1 monoclonal antibody targeting EGFR. Becotarug combined with osimertinib has shown encouraging efficacy in our previou…
View article: Synthesis and Structural Characterization for the Photolytic Degradation Impurities of Baricitinib Including Elucidation of the Possible Degradation Pathway
Synthesis and Structural Characterization for the Photolytic Degradation Impurities of Baricitinib Including Elucidation of the Possible Degradation Pathway Open
View article: Massage ameliorates lumbar disc herniation-related radicular pain in rats by suppressing TLR4/NLRP3 inflammasome signaling transduction
Massage ameliorates lumbar disc herniation-related radicular pain in rats by suppressing TLR4/NLRP3 inflammasome signaling transduction Open
Background Lumbar disc herniation (LDH) is a common spinal disease that can cause severe radicular pain. Massage, also known as Tuina in Chinese, has been indicated to exert an analgesic effect in patients with LDH. Nonetheless, the mechan…
View article: P2.04-02 AVANZAR: Phase III Study of Datopotamab Deruxtecan (Dato-DXd) + Durvalumab + Carboplatin as 1L Treatment of Advanced/mNSCLC
P2.04-02 AVANZAR: Phase III Study of Datopotamab Deruxtecan (Dato-DXd) + Durvalumab + Carboplatin as 1L Treatment of Advanced/mNSCLC Open
View article: OA09.05 A Phase 3 Study of Serplulimab Plus Chemotherapy as First-Line Treatment for Squamous Non-small-Cell Lung Cancer (ASTRUM-004)
OA09.05 A Phase 3 Study of Serplulimab Plus Chemotherapy as First-Line Treatment for Squamous Non-small-Cell Lung Cancer (ASTRUM-004) Open
View article: Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study
Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study Open
Purpose ASTRIS study aimed the largest to evaluate the effectiveness and safety of second- or higher-line osimertinib in patients with advanced/metastatic epidermal growth factor receptor ( EGFR ) T790M mutation-positive non–small cell lun…