Yazhuo Zhang
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View article: Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase
Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase Open
Dopamine receptor agonist (DA)-resistant prolactinoma presents a significant clinical challenge, highlighting the need for novel therapeutic strategies. Deguelin is a rotenoid compound derived from several plant species with unique antitum…
View article: [Expression of Concern] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas
[Expression of Concern] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas Open
Following the publication of the above paper, it was drawn to the Editor's attention by an interested reader that, regarding the western blot data shown in Fig. 5 on p. 507, the first set of GAPDH bands for the GH3 cell line were strikingl…
View article: Characteristics and influencing factors of neuroendocrine dysfunction in patients with adult-onset craniopharyngioma
Characteristics and influencing factors of neuroendocrine dysfunction in patients with adult-onset craniopharyngioma Open
Objective The aim of the study was to compare neuroendocrine dysfunction patterns in adult-onset adamantinomatous craniopharyngiomas (ACPs) and papillary craniopharyngiomas (PCPs) before and after surgery, and identify factors that influen…
View article: Supplementary effects of low-frequency transcutaneous electrical nerve stimulation on individuals with obesity combined with metabolic syndromes: study protocol for a randomised controlled trial
Supplementary effects of low-frequency transcutaneous electrical nerve stimulation on individuals with obesity combined with metabolic syndromes: study protocol for a randomised controlled trial Open
Introduction Obesity combined with metabolic syndrome is a major global public health problem. This trial aims to investigate the therapeutic effects of low-frequency transcutaneous electrical nerve stimulation (Lo-TENS) in individuals wit…
View article: ER membrane receptor FgGET2 plays critical roles in hyphal growth, asexual development, stress responses, and pathogenicity of Fusarium graminearum
ER membrane receptor FgGET2 plays critical roles in hyphal growth, asexual development, stress responses, and pathogenicity of Fusarium graminearum Open
Fusarium graminearum is the major causal agent of Fusarium head blight (FHB), a disease that considerably decreases wheat yield and quality. GET2 is an endoplasmic reticulum (ER) membrane receptor protein in the guided entry of tail-anchor…
View article: Development and validation of basement membrane-related signatures for predicting postoperative recurrence, tumor microenvironment and drug candidates in chordomas
Development and validation of basement membrane-related signatures for predicting postoperative recurrence, tumor microenvironment and drug candidates in chordomas Open
This study explored the critical role of BM-related genes in skull base chordoma, which affected postoperative recurrence and maligant behavior of chordoma via the PI3K-Akt signaling pathway.
View article: A fungal pathogen suppresses host leaf senescence to increase infection
A fungal pathogen suppresses host leaf senescence to increase infection Open
Phytopathogens such as Puccinia striiformis f. sp. tritici (Pst) induce pigment retention at pathogen infection sites. Although pigment retention is commonly observed in diverse pathosystems, its underlying physiological mechanism remains …
View article: Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway
Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway Open
These results indicate that this effect may be achieved by the overexpression of NPS-EMSCs through the activation of the PI3K/Akt/GSK3β signaling pathway. Overall, the overexpression of EMSCs significantly improved the therapeutic effect o…
View article: Author Correction: The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function
Author Correction: The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function Open
View article: Intersecting Landscapes of Exclusion: Mothers’ Perceptions and Spatial Tactics in the Public Spaces of Amman Downtown
Intersecting Landscapes of Exclusion: Mothers’ Perceptions and Spatial Tactics in the Public Spaces of Amman Downtown Open
Mothers in Amman Downtown frequently report feeling unsafe and excluded from public spaces. This study explores the impact of multiple layers of oppression, coupled with inadequate public spaces, on mothers’ perceptions. Using an intersect…
View article: Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease
Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease Open
View article: Effects of ozone on leaf nitrogen assimilation and nitrogen utilization in photosynthetic apparatus of Fagus crenata seedlings grown under different atmospheric CO2 and soil nitrogen conditions
Effects of ozone on leaf nitrogen assimilation and nitrogen utilization in photosynthetic apparatus of Fagus crenata seedlings grown under different atmospheric CO2 and soil nitrogen conditions Open
View article: Ethylene-Responsive Factor Hverf72 Regulates Starch Synthesis and B-Type Starch Granules Initiation in Barley
Ethylene-Responsive Factor Hverf72 Regulates Starch Synthesis and B-Type Starch Granules Initiation in Barley Open
View article: Hemoglobin-to-red blood cell distribution width ratio is negatively associated with stroke: a cross-sectional study from NHANES
Hemoglobin-to-red blood cell distribution width ratio is negatively associated with stroke: a cross-sectional study from NHANES Open
Numerous studies have suggested that the hemoglobin-to-red blood cell distribution width ratio (HRR) is associated with the onset, progression, and prognosis of various diseases. However, to the best of our knowledge, no research has condu…
View article: Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single‐cell transcriptomics
Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single‐cell transcriptomics Open
Background Pituitary neuroendocrine tumours (PitNETs) are common intracranial tumours that are highly heterogeneous with unpredictable growth patterns. The driver genes and mechanisms that are crucial for tumour progression in somatotroph …
View article: Assessing the nonlinear impact of green space exposure on psychological stress perception using machine learning and street view images
Assessing the nonlinear impact of green space exposure on psychological stress perception using machine learning and street view images Open
Introduction Urban green space (GS) exposure is recognized as a nature-based strategy for addressing urban challenges. However, the stress relieving effects and mechanisms of GS exposure are yet to be fully explored. The development of mac…
View article: Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing
Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing Open
The periosteum contains skeletal stem/progenitor cells that contribute to bone fracture healing. However, the in vivo identity of periosteal skeletal stem cells (P-SSCs) remains unclear, and membrane protein markers of P-SSCs that facilita…
View article: The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function
The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function Open
View article: Adjunctive benefits of low-frequency transcutaneous electrical nerve stimulation for obesity frequent chronic conditions: a systematic review
Adjunctive benefits of low-frequency transcutaneous electrical nerve stimulation for obesity frequent chronic conditions: a systematic review Open
Background Obesity is widely recognized for its role in predisposing individuals to a spectrum of chronic health conditions. Emerging preliminary evidence points to the potential benefits of low-frequency transcutaneous electrical nerve st…
View article: Mapping and Candidate Gene Analysis of an All-Stage Stem Rust Resistance Gene in Durum Wheat Landrace PI 94701
Mapping and Candidate Gene Analysis of an All-Stage Stem Rust Resistance Gene in Durum Wheat Landrace PI 94701 Open
Puccinia graminis f. sp. tritici (Pgt), the causal agent of wheat stem rust, poses a significant threat to global wheat production. Genetic resistance offers a cost-effective and sustainable solution. The durum wheat landrace PI 94701 was …
View article: Insights into climate change dynamics: A tourism climate index-based evaluation of Gilgit-Baltistan, Pakistan
Insights into climate change dynamics: A tourism climate index-based evaluation of Gilgit-Baltistan, Pakistan Open
The tourism industry is a significant contribution to the economy of many countries, including Pakistan. However, its activities often have a negative impact on the environment, particularly related to climate change. Notably, Pakistan ran…
View article: Mapping and Candidate Gene Analysis of an All-Stage Stem Rust Resistance Gene in Durum Wheat Landrace PI 94701
Mapping and Candidate Gene Analysis of an All-Stage Stem Rust Resistance Gene in Durum Wheat Landrace PI 94701 Open
Puccinia graminis f. sp. tritici (Pgt), the causal agent of wheat stem rust, poses a significant threat to global wheat production. Genetic resistance offers a cost-effective and sustainable solution. The durum wheat landrace PI 94701 was …
View article: Study on the Stock Enhancement Capacity of Main Target Species in the Waters of Zhongjieshan Islands
Study on the Stock Enhancement Capacity of Main Target Species in the Waters of Zhongjieshan Islands Open
The marine region of the Zhongjieshan Islands is an essential component and location for enhancement and release in Zhoushan Fishing Ground. The scientific assessment of the target species' ecological carrying capacity serves as the founda…
View article: Multi-omic analysis reveals the effects of interspecific hybridization on the synthesis of seed reserve polymers in a Triticum turgidum ssp. durum × Aegilops sharonensis amphidiploid
Multi-omic analysis reveals the effects of interspecific hybridization on the synthesis of seed reserve polymers in a Triticum turgidum ssp. durum × Aegilops sharonensis amphidiploid Open
View article: Retraction Note: LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis
Retraction Note: LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis Open
View article: Tracer movement and residence time distribution simulation: An initiative to improve the wetland water environment in the Helan Mountain impact plain
Tracer movement and residence time distribution simulation: An initiative to improve the wetland water environment in the Helan Mountain impact plain Open
The hydraulic residence time (HRT) serves as a critical temporal scale for calculating the duration of pollutants within a water body. The spatial and temporal variations of HRT play a crucial role in developing location-specific water man…
View article: Survival outcome and predictors of <scp>WHO</scp> grade 2 and 3 insular gliomas: A classification based on the tumor spread
Survival outcome and predictors of <span>WHO</span> grade 2 and 3 insular gliomas: A classification based on the tumor spread Open
Objective The study aimed to identify if clinical features and survival outcomes of insular glioma patients are associated with our classification based on the tumor spread. Methods Our study included 283 consecutive patients diagnosed wit…
View article: Fine-mapping and validation of Gpc-5B as the locus responsible for increases in the grain protein content, grain size, and spike density in common wheat (Triticum aestivum L.)
Fine-mapping and validation of Gpc-5B as the locus responsible for increases in the grain protein content, grain size, and spike density in common wheat (Triticum aestivum L.) Open
Grain protein content (GPC), grain size, and spike morphology are important traits for common wheat (Triticum aestivum) breeding. However, few genes positively regulating these three traits have been reported. In this study, the gene respo…
View article: TNF‐α can promote membrane invasion by activating the MAPK/MMP9 signaling pathway through autocrine in bone‐invasive pituitary adenoma
TNF‐α can promote membrane invasion by activating the MAPK/MMP9 signaling pathway through autocrine in bone‐invasive pituitary adenoma Open
Aims A bone‐invasive pituitary adenoma exhibits aggressive behavior, leading to a worse prognosis. We have found that TNF‐α promotes bone invasion by facilitating the differentiation of osteoclasts, however, before bone‐invasive pituitary …
View article: Three‐dimensional chromatin landscapes in somatotroph tumour
Three‐dimensional chromatin landscapes in somatotroph tumour Open
Background The three‐dimensional (3D) genome architecture plays a critical role inregulating gene expression. However, the specific alterations in thisarchitecture within somatotroph tumors and their implications for gene expression remain…