Explanipedia

Dexmedetomidine attenuates postoperative delirium by activating Nrf2 to reduce oxidative stress and blood-brain barrier disruption Open

Tengchen Feng, Jie Yao, Yanlin Chen, Jia‐Yi Wang, Ying‐Jie Zhu , et al. · 2025

DEX ameliorates POD by activating Nrf2, thereby reducing oxidative stress and inflammation, and maintaining BBB integrity. These findings suggest DEX is a potential therapeutic agent for POD, highlighting the Nrf2 pathway as a novel target…

The efficacy and safety of inhaled peptide YKYY017 for COVID-19 patients with mild illness: a phase 2 randomized controlled trial Open

Yeming Wang, Lianhan Shang, Lei Wu, Wang Xia, Banghan Ding , et al. · 2025

The Excavation and Practice of Ideological and Political Elements in “Civil Engineering Drawing and CAD” Open

Sirui Peng, Yeming Wang, Fan Xu · 2025

Ideological and political education in courses has become an important part of curriculum teaching and research. This paper continuously excavates the ideological and political elements contained in the course of “Civil Engineering Drawing…

Correction: Morphologic profiles of comminuted midshaft clavicle fractures: a preliminary study Open

Yeming Wang, Chao Ji, Jian Li, Wanfu Wei · 2025

Reading of human acute immune dynamics in omicron SARS-CoV-2 breakthrough infection Open

Haibo Li, Hongyu Liu, Hongping Wu, Chang Ming Guo, Wenting Zuo , et al. · 2025

The dynamics of the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infections remain unclear, particularly when compared to responses in naive individuals. In this longitudinal prospective coho…

Health outcomes one year after Omicron infection among 12,789 adults: a community-based cross-sectional study Open

Hui Zhang, Peng Yang, Xiaoying Gu, Ying Sun, Rongling Zhang , et al. · 2025

Time-resolved scRNA-seq reveals transcription dynamics of polarized macrophages with influenza A virus infection and antigen presentation to T cells Open

Jiapei Yu, Congcong Shang, Xiaoyan Deng, Ju Jia, Xiao Shang , et al. · 2024

Throughout history, the influenza A virus has caused numerous devastating global pandemics. Macrophages, as pivotal innate immune cells, exhibit a wide range of immune functions characterized by distinct polarization states, reflecting the…

Age‐related Differences in Volumetric Bone Mineral Density, Structure, and Bone Strength of Surgical Neck of Humerus in Postmenopausal Women Open

Yeming Wang, Jian Li, Yutao Men, Wanfu Wei · 2024

Objective Postmenopausal changes in bone mass and structure compromise the mechanical properties of proximal humerus, predisposing it to low‐energy fractures with complex morphology. The aim of the study is to investigate associations of b…

Effectiveness and safety of Sanhan Huashi granules versus nirmatrelvir–ritonavir in adult patients with COVID-19: A randomized, open-label, multicenter trial Open

Xiaohui Zou, Kang Chang, Guohui Fan, Huanwei Zheng, Hezheng Shen , et al. · 2024

Sanhan Huashi granules (SHG) demonstrated therapeutic effects against coronavirus disease 2019 (COVID-19) in observational studies. In order to compare the effectiveness and safety of SHG and nirmatrelvir-ritonavir in treating adults with …

The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China Open

Wenting Zuo, Di He, Chaoyang Liang, Shiyu Du, Zhan Hua , et al. · 2024

Association of Monocyte Count With Lung Function and Exercise Capacity Among Hospitalized COVID‐19 Survivors: A 2‐Year Cohort Study Open

Xiaoying Gu, Lixue Huang, Xia Li, Yuting Zhou, Hui Zhang , et al. · 2024

Background Abnormal changes of monocytes have been observed in acute COVID‐19, whereas associations of monocyte count with long COVID were not sufficiently elucidated. Methods A cohort study was conducted among COVID‐19 survivors discharge…

Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19 Open

Bin Cao, Yeming Wang, Hongzhou Lu, Chaolin Huang, Yumei Yang , et al. · 2024

Early administration of simnotrelvir plus ritonavir shortened the time to the resolution of symptoms among adult patients with Covid-19, without evident safety concerns. (Funded by Jiangsu Simcere Pharmaceutical; ClinicalTrials.gov number,…

Chronic active SARS-CoV-2 in B-cell immunodeficiency Open

Jiuyang Xu, Hui Zhang, Yeming Wang, Shiyao Wang, Bin Cao · 2024

3-year outcomes of discharged survivors of COVID-19 following the SARS-CoV-2 omicron (B.1.1.529) wave in 2022 in China: a longitudinal cohort study Open

Hui Zhang, Chaolin Huang, Xiaoying Gu, Yeming Wang, Xia Li , et al. · 2023

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study Open

Chaolin Huang, Lixue Huang, Yeming Wang, Xia Li, Lili Ren , et al. · 2023

Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials Open

Alain Amstutz, Benjamin Speich, France Mentré, Corina S. Rueegg, Drifa Belhadi , et al. · 2023

Intrinsic Cortical Property Analysis of the Medial Column of Proximal Humerus Open

Yeming Wang, Jian Li, Yutao Men, Wanfu Wei · 2023

Objective Adequate mechanical support of the medial column is paramount to maintain fracture reduction in locking plating of proximal humerus fractures. However, intrinsic cortical properties of the medial column are rarely discussed. The …

Selection of Surgical Approach and Clinical Significance of Lower Cervical Spine Injuries Guided by SLIC Scoring System Open

Xinming Yang, Xuyang Zhang, Yongli Jia, Yanlin Yin, Peinan Zhang , et al. · 2023

Objective: To explore the feasibility and clinical significance of surgical approach selection for cervical spine injury guided by SLIC scoring system. Methods: The clinical data of 75 patients with lower cervical injury surgery from Janua…

Long-term outcomes in COVID-19 patients who recovered from the first wave of the pandemic Open

Dan Cui, Simiao Chen, Shuo Feng, Mengmeng Jia, Yeming Wang , et al. · 2022

This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019 (COVID-19) in Jianghan District (Wuhan, China). The results showed that 61.4% of COVID-19 patients reported at least one symptom and 8.8% had dep…

Menopause-related cortical loss of the humeral head region mainly occurred in the greater tuberosity Open

Yeming Wang, Jian Li, Yutao Men, Wanfu Wei · 2022

Aims Proximal humerus fractures are commonly observed in postmenopausal women. The goal of this study was to investigate menopause-related changes in cortical structure of the humeral head. Materials and methods Clinical computed tomograph…

Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study Open

Lixue Huang, Xia Li, Xiaoying Gu, Hui Zhang, Xiang Ren , et al. · 2022

Improved Hybrid Response Surface Method Based on Double Weighted Regression and Vector Projection Open

Yu Xia, Yeming Wang · 2022

In order to increase the accuracy and stability of the classical response surface method and relevant method, a new improved response surface method based on the idea of double weighting factors and vector projection method is proposed. Th…

Rheumatic Symptoms Following Coronavirus Disease 2019 (COVID-19): A Chronic Post–COVID-19 Condition Open

Dan Cui, Yeming Wang, Lixue Huang, Xiaoying Gu, Zhisheng Huang , et al. · 2022

Background Detailed characteristics of rheumatic symptoms of coronavirus disease 2019 (COVID-19) were still unknown. We aim to investigate the proportions, characteristics, and risk factors of this condition. Methods In this prospective, l…

Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells Open

Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu , et al. · 2022

Influenza A virus still represents a noticeable epidemic risk to international public health at present, despite the extensive use of vaccines and anti-viral drugs. In the fight against pathogens, the immune defence lines consisting of div…

The Efficacy and Safety of Janus Kinase Inhibitors for Patients With COVID-19: A Living Systematic Review and Meta-Analysis Open

Xueyang Zhang, Lianhan Shang, Guohui Fan, Xiaoying Gu, Jiuyang Xu , et al. · 2022

Background Cytokine storm observed in patients with severe Coronavirus Disease 2019 (COVID-19) contributes to poor clinical outcomes and increased mortality. Janus kinases (JAKs) are important mediators in the cytokine storm. Therefore, we…

Association of acute kidney injury with 1-year outcome of kidney function in hospital survivors with COVID-19: A cohort study Open

Xiaoying Gu, Lixue Huang, Dan Cui, Yeming Wang, Yimin Wang , et al. · 2022

Effects of Remdesivir in Hospitalized Patients with COVID-19: Systematic Review and Individual Patient Data Meta-Analysis of Randomized Clinical Trials Open

Alain Amstutz, Benjamin Speich, France Mentré, Corina S. Rueegg, Drifa Belhadi , et al. · 2022

Presence of Anti-MDA5 Antibody and Its Value for the Clinical Assessment in Patients With COVID-19: A Retrospective Cohort Study Open

Geng Wang, Qian Wang, Yeming Wang, Changzheng Liu, Linghang Wang , et al. · 2021

Background Striking similarities have been found between coronavirus disease 2019 (COVID-19) and anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab)-related dermatomyositis, implying a shared autoinflammatory aberrance. He…

Prospective Evaluation of a Rapid Clinical Metagenomics Test for Bacterial Pneumonia Open

Shengrui Mu, Long Hu, Ye Zhang, Yingmei Liu, Xiaojing Cui , et al. · 2021

Background The diagnosis of bacterial pathogens in lower respiratory tract infections (LRI) using conventional culture methods remains challenging and time-consuming. Objectives To evaluate the clinical performance of a rapid nanopore-sequ…

Effect of Dexmedetomidine on The Neuroglobin Expression in Elderly Patients With Minimally Invasive Coronary Artery Bypass Graft Surgery Open

Yan Gao, Huidan Yu, Wenlong Wang, Yeming Wang, Jinliang Teng , et al. · 2021

Background: To study the effect of dexmedetomidine (Dex) on the expression of Neuroglobin (Ngb) and postoperative cognitive function in elderly patients undergoing minimally invasive coronary artery bypass surgery. Methods: Forty patients,…

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