Nataliya Mitina
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View article: PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production
PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production Open
The drug complexation with novel PEGylated carriers is a promising way for efficient therapeutic development.
View article: Changes in bioenergetic characteristics of the murine lymphoma cells under the action of a thiazole derivative in complex with polymeric nanoparticles
Changes in bioenergetic characteristics of the murine lymphoma cells under the action of a thiazole derivative in complex with polymeric nanoparticles Open
Background. Mitochondria can influence cancer cells both indirectly via reactive oxygen species mediation and directly through mitochondrial biogenesis. Energy production in mitochondria is crucial as it facilitates the synthesis of essent…
View article: Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier
Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier Open
Many chemotherapeutics drugs have low water solubility, which potentially can decrease their anticancer potential. The use of drug delivery systems has proven to be highly effective in addressing the challenges associated with delivering h…
View article: Genotoxicity and acute toxicity of 2-amino-5-benzylthiazole in complex with polymeric nanocarrier in Allium bioassay
Genotoxicity and acute toxicity of 2-amino-5-benzylthiazole in complex with polymeric nanocarrier in Allium bioassay Open
Background. The search for optimal methods of selective and integral determination of various cytotoxic compounds in biological fluids and tissues, which would have high sensitivity and allow for quick and reliable assessment and detection…
View article: Li<sup>+</sup> intercalation current generation in amorphous and crystalline MoS<sub>2</sub>: Experiment and theory
Li<sup>+</sup> intercalation current generation in amorphous and crystalline MoS<sub>2</sub>: Experiment and theory Open
In this work, crystalline and amorphous nano-MoS 2 materials for effective Li + -intercalation current generation have been synthesized. The effect of disordering on the structural and electrochemical properties of nano-MoS 2 has been syst…
View article: Cannabimimetic N-Stearoylethanolamine as “Double-Edged Sword” in Anticancer Chemotherapy: Proapoptotic Effect on Tumor Cells and Suppression of Tumor Growth versus Its Bio-Protective Actions in Complex with Polymeric Carrier on General Toxicity of Doxorubicin In Vivo
Cannabimimetic N-Stearoylethanolamine as “Double-Edged Sword” in Anticancer Chemotherapy: Proapoptotic Effect on Tumor Cells and Suppression of Tumor Growth versus Its Bio-Protective Actions in Complex with Polymeric Carrier on General Toxicity of Doxorubicin In Vivo Open
This study reports a dose-dependent pro-apoptotic action of synthetic cannabimimetic N-stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models. No antioxidant or cytoprotective effects of NSE were foun…
View article: Bioenergetic characteristics of the murine Nemeth-Kellner lymphoma cells exposed to thiazole derivative in complex with polymeric nanoparticles
Bioenergetic characteristics of the murine Nemeth-Kellner lymphoma cells exposed to thiazole derivative in complex with polymeric nanoparticles Open
The development of a new anticancer drugs targeted at energy metabolism of tumor cells is a promising approach for cancer treatment. The aim of our study was to investigate the action of thiazole derivative N-(5-benzyl-1,3-thiazol-2-yl)-3…
View article: Generation of ROS under the influence of thiazole derivative and its complexes with PEG-based polymeric nanoparticles
Generation of ROS under the influence of thiazole derivative and its complexes with PEG-based polymeric nanoparticles Open
Aim.To determine the in vitro effect of thiazole derivative and its complex with polyethylene glycol (PEG)-based nanoscale particles on ROS generation in the NK/Ly lymphoma cells and hepatocytes of mice.Methods.The effects of BF-1 (N-(5-be…
View article: Covalent Conjugate of Ser-Pro-Cys Tripeptide with PEGylated Comb-Like Polymer as Novel Killer of Human Tumor Cells
Covalent Conjugate of Ser-Pro-Cys Tripeptide with PEGylated Comb-Like Polymer as Novel Killer of Human Tumor Cells Open
Recently, we detected a previously unknown Ser-Pro-Cys (SPC) tripeptide in the blood serum of multiple sclerosis patients. Its role as a biomarker of the autoimmune disease was suggested, although its origin and real biological activity re…
View article: Transformation of the moss (Ceratodon purpureus) with plasmid DNA delivered by novel block-copolymers of the dimethylaminoethyl methacrylate
Transformation of the moss (Ceratodon purpureus) with plasmid DNA delivered by novel block-copolymers of the dimethylaminoethyl methacrylate Open
Keywords: polymeric carrier, poly(2-dimethylamino)ethyl methacrylate, moss Ceratodon purpureus, protoplasts transformation, toxicity.
View article: Reduction in viability oh human cervix carcinoma HeLa cells by p21 gene transferred with block polymeric dimethylaminoethyl methacrylate-based carrier
Reduction in viability oh human cervix carcinoma HeLa cells by p21 gene transferred with block polymeric dimethylaminoethyl methacrylate-based carrier Open
Background. Various cationic polymers have been proposed for use as carriers of genetic materials in biotechnology and biomedicine. The poly(2-dimethylamino)ethyl-methacrylate (poly(DMAEMA)) demonstrated high transfection efficiency and lo…
View article: Effect of a novel thiazole derivative and its complexes with polymeric carriers on the processes of lipid peroxidation in lymphoma cells
Effect of a novel thiazole derivative and its complexes with polymeric carriers on the processes of lipid peroxidation in lymphoma cells Open
Background. Many types of tumors are sensitive to changes in prooxidant-antioxidant balance. Thus, further studies on reactive oxygen species inducing antitumor drugs that generate oxidative stress-dependent cytotoxic effects are promising…
View article: Unexpected Resistance of Polyelectrolyte Brushes Formed via Surface-Initiated Polymerization on Glass and Sitall
Unexpected Resistance of Polyelectrolyte Brushes Formed via Surface-Initiated Polymerization on Glass and Sitall Open
Poly(dimethylaminoethyl methacrylate) and poly(2-carboxyethyl acrylate) brushes, including enriched with Li + cations, were grafted to the glass and glass-ceramic via radical polymerization initiated by immobilized low molecular weight 4,4…
View article: Antineoplastic Activity of Water-Soluble Form of Novel Kinase Inhibitor 1-(4-Chlorobenzyl)-3-chloro-4-(3-trifluoromethylphenylamino)-1H-pyrrole-2,5-dione immobilized on Polymeric Poly(PEGMA-co-DMM) Carrier
Antineoplastic Activity of Water-Soluble Form of Novel Kinase Inhibitor 1-(4-Chlorobenzyl)-3-chloro-4-(3-trifluoromethylphenylamino)-1H-pyrrole-2,5-dione immobilized on Polymeric Poly(PEGMA-co-DMM) Carrier Open
The maleimide derivative 1-(4-chlorobenzyl)-3-chloro-4-(3-trifluoromethylphenylamino)-1H-pyrrole-2,5-dione (MI-1) was synthesized as inhibitor of several protein kinases, however, its application is hindered by its poor water solubility. I…
View article: Photocatalytic activity of layered MoS<sub>2</sub> in the reductive degradation of bromophenol blue
Photocatalytic activity of layered MoS<sub>2</sub> in the reductive degradation of bromophenol blue Open
Molybdenum disulphide (MoS 2 ) is a layered material with interesting photocatalytic properties.
View article: Safety profile of thiazole derivative and its complex with PEG-based polymeric nanoparticles on liver and blood cells in tumor-bearing mice
Safety profile of thiazole derivative and its complex with PEG-based polymeric nanoparticles on liver and blood cells in tumor-bearing mice Open
Background. Drug delivery systems (DDS) have demonstrated a significant ability to overcome many of the challenges associated with the delivery of hydrophobic chemotherapeutic compounds to tumor tissues. However, hepatotoxicity and suppres…
View article: Effect of a novel thiazole derivative and its complex with polymeric carriers on the activity of antioxidant enzymes in murine lymphoma cells
Effect of a novel thiazole derivative and its complex with polymeric carriers on the activity of antioxidant enzymes in murine lymphoma cells Open
Background. Previous studies have shown a pronounced cytotoxic effect of thiazole derivatives in combination with polymeric carriers on tumor cells. At the same time, the derivatives were not cytotoxic against non-cancerous cells in vitro.…
View article: Experimental and computer simulation studies of the micelles formed by comb-like PEG-containing polymeric surfactants as potential enzyme scaffolds
Experimental and computer simulation studies of the micelles formed by comb-like PEG-containing polymeric surfactants as potential enzyme scaffolds Open
The industrial implementation of biofuel production from lignocellulosic biomass faces a number of economic obstacles. One of these is the cost of enzymes, typically used for cellulose hydrolysis. Nature provides some hints towards the eff…
View article: An influence of complexes of therapeutic antisense oligodeoxynucleotides with cationic polymers on cell respiration
An influence of complexes of therapeutic antisense oligodeoxynucleotides with cationic polymers on cell respiration Open
Keywords: antisense oligodeoxynucleotides, polyelectrolyte complexes, cytotoxicity, redox processes, prion
View article: Application of polymeric dimethylaminoethyl methacrylate based carriers of plasmid DNA for genetic transformation of Ceratodon purpureus moss
Application of polymeric dimethylaminoethyl methacrylate based carriers of plasmid DNA for genetic transformation of Ceratodon purpureus moss Open
Introduction. Genetic engineering in plants is of great importance for agriculture, biotechnology and medicine, and nanomaterials are widely used for genetic engineering. The aim of present study was to evaluate the potential of poly(2-dim…
View article: Effect of a novel thiazole derivative and its complex with a polymeric carrier on stability of DNA in human breast cancer cells
Effect of a novel thiazole derivative and its complex with a polymeric carrier on stability of DNA in human breast cancer cells Open
Thiazole derivatives are perspective antitumor compounds characterized by a broad range of bioactivity, while polymeric carriers are widely used to enhance the efficiency of biological action of drugs, improve their biocompatibility and wa…
View article: Effect of thiazole derivative complexed with nanoscale polymeric carriers on cellular ultrastructure of murine lymphoma cells in vivo
Effect of thiazole derivative complexed with nanoscale polymeric carriers on cellular ultrastructure of murine lymphoma cells in vivo Open
Background. A pronounced cytotoxic action of the thiazole derivatives complexed with polymeric carriers on tumor cells in vitro was reported earlier, while no cytotoxicity of these compounds was detected toward noncancerous cells. It was f…
View article: Anionic Polyelectrolyte Hydrogel as an Adjuvant for Vaccine Development
Anionic Polyelectrolyte Hydrogel as an Adjuvant for Vaccine Development Open
Vaccination is one of the main methods for the specific prevention of infectious diseases. The disadvantage of vaccination is the use of pathogens (live or attenuated viruses and bacteria) that can lead to the development of a disease. Rec…
View article: Morphology of the Micelles Formed by a Comb-Like PEG-Containing Copolymer Loaded with Antitumor Substances with Different Water Solubilities
Morphology of the Micelles Formed by a Comb-Like PEG-Containing Copolymer Loaded with Antitumor Substances with Different Water Solubilities Open
The controlled delivery of anticancer drugs is driven by their interaction with carrier molecules. By creating complicated micelle-like complexes, amphiphilic polymers provide an opportunity to load drugs of various kinds. In this work, th…
View article: Novel amphiphilic block-copolymer forming stable micelles and interpolyelectrolyte complexes with DNA for efficient gene delivery
Novel amphiphilic block-copolymer forming stable micelles and interpolyelectrolyte complexes with DNA for efficient gene delivery Open
Novel amphiphilic poly(DMAEMA)-block-poly(NVP-co-BA-co-AEM) (BP83-1) forms stable micelles and BP83-1/pDNA complexes possessing controlled size, charge and enhanced aggregation degree. It was found that the formation of the micelles by BP8…
View article: Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier
Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier Open
Complexation of 4-thiazolidinone derivatives with a PEG-containing polymeric nanocarrier provided them with water solubility and enhanced pro-apoptotic effects in rat glioma C6 cells.
View article: Increased antitumor efficiency and reduced negative side effects in laboratory mice of 4-thiazolidinone derivatives in complexes with PEG-containing polymeric nanocarrier
Increased antitumor efficiency and reduced negative side effects in laboratory mice of 4-thiazolidinone derivatives in complexes with PEG-containing polymeric nanocarrier Open
Aim. To study an anticancer activity and to measure cytological and enzymatic indicators of general toxicity of 4-thiazolidinone-based compounds (Les-3288, Les-3833) in the NK/Ly lymphoma grafted to BALB/C mice. Methods. BALB/C mice were i…