Explanipedia

Multi-pronged surveillance to understand the spatiotemporal correlations among macaques, vectors and humans in Plasmodium knowlesi malaria transmission Open

Wei Kit Phang, Nantha Kumar Jeyaprakasam, Sandthya Pramasivan, Zailiza Suli, Jenn Zhueng Tam , et al. · 2025

Background Plasmodium knowlesi , a non-human primate (NHP) malaria parasite, has become a major public health concern in Malaysia and is now the leading cause of human malaria infections in the country. The transmission of P. knowlesi invo…

Zoonotic brugian filariasis past and present trends in malaysia: A systematic review and proportionate meta-analysis Open

Muhammad Sulaiman Hafizu, Quazim Olawale Junaid, Rahmat Sagara, R. Ravi, Fong Mun Yik , et al. · 2025

Induction of gametocytogenesis in human malaria parasites: from stress to genome editing Open

R. Subramaniam, Zi Yan Chiew, Nabel Darwish binti Zuhaidi, Yee Ling Lau, Fei Wen Cheong · 2025

Gametocytogenesis is a crucial process in which malaria parasites transition from their asexual stage to the sexual-stage gametocytes. This transformation enables the parasite to infect and multiply within the Anopheles mosquito, the vecto…

Vernonia amygdalina (Delile) exhibits in vitro anti-plasmodial activities against Plasmodium knowlesi Open

Zulkefli N.Z., Fei Wen Cheong, Amirah Amir, Yee Ling Lau · 2025

Malaria is a global public health concern, where Plasmodium knowlesi contributes to most human malaria cases in Malaysia. The leaves of Vernonia amygdalina (Delile) were found to exhibit significant anti-plasmodial properties and are commo…

A novel micronemal protein MP38 is involved in the invasion of merozoites into erythrocytes Open

Tuyet-Kha Nguyen, Son Truong Nguyen, Van-Truong Nguyen, Sunghun Na, Robert W. Moon , et al. · 2025

The absence of an in vitro cultivation system for Plasmodium vivax hinders the exploration of molecular targets for vaccine development. To address this, functional studies often rely on alternative models, such as P. knowlesi , due to its…

Aktiviti Antimalaria dan Skizontisida Sebatian Analog 4-aminokuinolina-pirano[2,3-c]pirazol terhadap Plasmodium knowlesi A1H1 dan Analisis Dok Molekul Open

Subhash Kamal, Amatul Hamizah Ali, Ng Yee Ling, Mohd Asyraf Shamsudin, Siti Nur Hidayah Jamil , et al. · 2024

Kemunculan jangkitan zoonosis Plasmodium knowlesi dan perkembangan kerintangan parasit terhadap ubat antimalaria sedia ada memacu penyelidikan dinamik bagi meneroka dan mencari agen antimalaria yang baharu. Penghibridan farmakoforik ialah …

<i>Plasmodium knowlesi</i> Infection Is Associated With Elevated Circulating Biomarkers of Brain Injury and Endothelial Activation Open

Cesc Bertran-Cobo, Elin Dumont, Naqib Rafieqin Noordin, Meng Yee Lai, William J. Stone , et al. · 2024

Background Malaria remains a major public health concern with substantial morbidity and mortality worldwide. In Malaysia, the emergence of Plasmodium knowlesi has led to a surge in zoonotic malaria cases and deaths in recent years. Signs o…

Sintesis, Aktiviti Antimalaria dan Pendekatan Dinamik Molekul Kompleks Logam Salofen Open

Amatul Hamizah Ali, Nur Hafizah Mukhtar, Yee Ling Ng, Nur Aqilah Zahirah Norazmi, Hani Kartini Agustar , et al. · 2024

Malaria masih merupakan salah satu penyakit berjangkit yang utama di kawasan beriklim tropika. Pelbagai ubat antimalaria telah diperkenalkan sebelum ini seperti klorokuina, primakuina dan artemisinin. Namun, keberkesanan ubat antimalaria m…

<i>Plasmodium knowlesi</i>infection is associated with elevated circulating biomarkers of brain injury and endothelial activation Open

Cesc Bertran-Cobo, Elin Dumont, Naqib Rafieqin Noordin, Meng Yee Lai, William J. Stone , et al. · 2024

Introduction Malaria remains a major public health concern with substantial morbidity and mortality worldwide. In Malaysia, the emergence of Plasmodium knowlesi has led to a surge in zoonotic malaria cases and deaths in recent years. Signs…

Detection of Plasmodium knowlesi in whole blood samples with sandwich enzyme-linked immunosorbent assay (ELISA) using rhoptry-associated protein 1 specific polyclonal antibodies Open

Wan Siti Maryam Wan Nazri, Yee Ling Lau, Cheong Fei Wen · 2024

Background & objectives: Plasmodium knowlesi , a simian malaria species, is now known to infect humans. Due to disadvantages in the current diagnosis methods, many efforts have been placed into developing new methods to diagnose the diseas…

The prevalence of simian malaria in wild long-tailed macaques throughout Peninsular Malaysia Open

Shahhaziq Shahari, Mohd Lutfi Abdullah, Anis Adlina Binti Isman Rohimly, Norsharina Binti Ashrat, Amirah Amir , et al. · 2024

Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment Open

Amirah Hani Ramli, Puspanjali Swain, Muhammad Syafiq Akmal Mohd Fahmi, Faridah Abas, Sze Wei Leong , et al. · 2024

Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated a continuous search for …

Characterization of merozoite-specific thrombospondin-related anonymous protein (MTRAP) in Plasmodium vivax and P. knowlesi parasites Open

Nguyen Sy Thau, Tuyet-Kha Nguyen, Truong Quang Nguyen, Thi-Thanh Hang Chu, Sunghun Na , et al. · 2024

Plasmodium vivax , the most widespread human malaria parasite, and P. knowlesi , an emerging Plasmodium that infects humans, are the phylogenetically closest malarial species that infect humans, which may induce cross-species reactivity ac…

Porous borders at the wild-crop interface promote weed adaptation in Southeast Asia Open

Linfeng Li, Tonapha Pusadee, Marshall J. Wedger, Yaling Li, Mingrui Li , et al. · 2024

High reproductive compatibility between crops and their wild relatives can provide benefits for crop breeding but also poses risks for agricultural weed evolution. Weedy rice is a feral relative of rice that infests paddies and causes seve…

Digital microscope-assisted photography improves the accuracy of mosquito wing measurement Open

Zulhisham Zulzahrin, Meng Li Wong, Mohd Redzuan Ahmad Naziri, Yee Ling Lau, Indra Vythilingam , et al. · 2024

Wing measurement is an important parameter in many entomological studies. However, the methods of measuring wings vary with studies, and a gold standard method was not available for this procedure. This in turn limits researchers from conf…

Detection of Plasmodium knowlesi in whole blood samples with sandwich enzyme-linked immunosorbent assay (ELISA) using rhoptry-associated protein 1 specific polyclonal antibodies Open

Wan Siti Maryam Wan Nazri, Yee Ling Lau, Cheong Fei Wen · 2023

Background & objectives: Plasmodium knowlesi , a simian malaria species, is now known to infect humans. Due to disadvantages in the current diagnosis methods, many efforts have been placed into new method developments to diagnose the disea…

Correction: RNA purification-free detection of SARS-CoV-2 using reverse transcription loop-mediated isothermal amplification (RT-LAMP) Open

Meng Yee Lai, Jeyanthi Suppiah, Ravindran Thayan, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2023

Correction to: Clinical testing on SARS-CoV-2 swab samples using reverse-transcription loop-mediated isothermal amplification (RT-LAMP) & Two extraction-free reverse transcription loop-mediated isothermal amplification assays for detection of SARS-CoV-2 Open

Yee Ling Lau · 2023

Correction: Droplet digital polymerase chain reaction (ddPCR) for the detection of Plasmodium knowlesi and Plasmodium vivax Open

Punitha Mahendran, Jonathan Wee Kent Liew, Amirah Amir, Xiao-Teng Ching, Yee Ling Lau · 2023

Correction: Plasmodium knowlesi: the game changer for malaria eradication Open

Wenn-Chyau Lee, Fei Wen Cheong, Amirah Amir, Meng Yee Lai, Jia Hui Tan , et al. · 2023

Correction: Validation of SYBR green I based closed‐tube loop‐mediated isothermal amplification (LAMP) assay for diagnosis of knowlesi malaria Open

Meng Yee Lai, Choo Huck Ooi, Yee Ling Lau · 2023

The prevalence of simian malaria in wild long-tailed macaques throughout Peninsular Malaysia Open

Shahhaziq Shahari, Mohd Lutfi Abdullah, Anis Adlina Binti Isman Rohimly, Norsharina Binti Ashrat, Amirah Amir , et al. · 2023

The parasite Plasmodium knowlesi has been the sole cause of malaria in Malaysia from 2018–2022. Due to the high burden of P. knowlesi in Malaysia, this has hampered Malaysia from achieving the malaria-free status awarded by the World Healt…

Corrigendum to “Colorimetric detection of SARS-CoV-2 by uracil-DNA glycosylase (UDG) reverse transcription loop-mediated isothermal amplification (RT-LAMP)” [International Journal of Infectious Diseases 120 (2023) Pages 132-134] Open

Meng Yee Lai, Fatma Diyana Mohd Bukhari, Nur Zulaikha Zulkefli, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2023

Issue Information Open

Zhu Zhou, Patricia W. Slattum, Alice Ke, Lei Zhang, Themistoklis Bellos , et al. · 2023

Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…

A simple and purification-free nucleic acid extraction method for rapid diagnosis of malaria Open

Lee Phone Youth Zen, Meng Yee Lai, Mohd Hafizi Abdul Hamid, Jenarun Jelip, Rose Nani Mudin , et al. · 2023

In a point of care setting for the diagnosis of malaria, DNA extraction using conventional methods are time-consuming and complicated. Therefore, in this study we aim to utilize a simple nucleic acid extraction method to directly extract D…

Genetic diversity and in silico analysis of Plasmodium knowlesi Serine Repeat Antigen (SERA) 3 antigen 2 in Malaysia Open

Jia Hui Tan, Hans Xing Ding, Mun Yik Fong, Yee Ling Lau · 2023

Plasmodium knowlesi is the leading cause of malaria in Malaysia. Serine Repeat Antigens (SERAs) have an essential role in the parasite life cycle. However, genetic characterization on P. knowlesi SERA3 Ag2 (PkSERA3 Ag2) is lacking. In the …

Evaluation of A Simple DNA Extraction Method and Its Combination with Loop-Mediated Isothermal Amplification Assays for Rapid Plasmodium knowlesi Diagnosis Open

Meng Yee Lai, Mohd Hafizi Abdul Hamid, Jenarun Jelip, Rose Nani Mudin, Yee Ling Lau · 2023

The initial and vital stage in the diagnosis of malaria involves extracting DNA. The efficiency of malaria testing is restricted by the multiple steps involved in commercial DNA extraction kits. We attempted to improve an existing loop-med…

Simian malaria: a narrative review on emergence, epidemiology and threat to global malaria elimination Open

Kimberly Fornace, Gabriel Zorello Laporta, Indra Vythilingham, Tock H. Chua, Kamruddin Ahmed , et al. · 2023

Inter-Population Genetic Diversity and Clustering of Merozoite Surface Protein-1 (pkmsp-1) of Plasmodium knowlesi Isolates from Malaysia and Thailand Open

Naqib Rafieqin Noordin, Yee Ling Lau, Fei Wen Cheong, Mun Yik Fong · 2023

The genetic diversity of pkmsp-1 of Malaysian Plasmodium knowlesi isolates was studied recently. However, the study only included three relatively older strains from Peninsular Malaysia and focused mainly on the conserved blocks of this ge…

Point-of-Care Diagnosis of Malaria Using a Simple, Purification-Free DNA Extraction Method Coupled with Loop-Mediated Isothermal Amplification-Lateral Flow Open

Meng Yee Lai, Lee Phone Youth Zen, Mohd Hafizi Abdul Hamid, Jenarun Jelip, Rose Nani Mudin , et al. · 2023

We propose a protocol suitable for point-of-care diagnosis of malaria utilizing a simple and purification-free DNA extraction method with the combination of loop-mediated isothermal amplification assay and lateral flow (LAMP-LF). The multi…

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