Yee Siang Lim
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View article: A clinically defined and xeno-free hydrogel system for regenerative medicine
A clinically defined and xeno-free hydrogel system for regenerative medicine Open
Biofabricated scaffolds facilitate bona fide cellular interactions, cell type specification, and the formation of three-dimensional tissue architecture from human pluripotent stem cells (hPSCs). However, poorly defined and non-clinically a…
View article: CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice
CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice Open
Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) i…
View article: Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease
Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease Open
We developed a hepatic organoid platform with human cells that can be used to model complex liver diseases, including NASH.
View article: Modelling non-alcoholic fatty liver disease using patient derived liver stem cells and hepatic organoids
Modelling non-alcoholic fatty liver disease using patient derived liver stem cells and hepatic organoids Open
Non-alcoholic fatty liver disease (NAFLD) is described as a global epidemic. With no approved drugs in the market, the disease imposes huge economic and healthcare burden to the society. In-vitro models are deemed as a potential method to …
View article: Mismatched filter for transmit waveform with frequency notches
Mismatched filter for transmit waveform with frequency notches Open
In order to reduce radar interference on communication systems within shared bands, the radar transmit waveform forms frequency notches in the shared bands. However, because of the notches, the auto‐correlation of the transmit waveform wit…
View article: Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Open