Yan Tan
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View article: Caudate nucleus atrophy as a neuroimaging feature of mild cognitive impairment induced by occupational aluminum exposure
Caudate nucleus atrophy as a neuroimaging feature of mild cognitive impairment induced by occupational aluminum exposure Open
Occupational aluminum (Al) exposure is linked to mild cognitive impairment (MCI), yet its neuroanatomical mechanisms remain unclear. We investigated gray matter volume (GMV) alterations specifically associated with Al-induced MCI. This stu…
View article: Phenotypic stratification of Low-grade Glioma using multimodal MRI via outcome-weighted integrative clustering
Phenotypic stratification of Low-grade Glioma using multimodal MRI via outcome-weighted integrative clustering Open
View article: Development and validation of radiopathomics models for predicting molecular subtypes and WHO grades in adult-type diffuse gliomas: a multicenter study
Development and validation of radiopathomics models for predicting molecular subtypes and WHO grades in adult-type diffuse gliomas: a multicenter study Open
The proposed radiopathomics models demonstrate robust diagnostic performance by synergizing cross-scale features, offering a clinically actionable tool for ADG stratification.
View article: Survival risk stratification of 2021 WHO glioblastoma by MRI radiomics and biological exploration
Survival risk stratification of 2021 WHO glioblastoma by MRI radiomics and biological exploration Open
The radiomics model might be a new prognostic biomarker for IDH-wt GBM. The combined model shows an approximately 12.57% improvement of stratification ability over the clinical model. Additionally, the significant activation of GABA recept…
View article: Survival prediction in gliomas based on MRI radiomics combined with clinical factors and molecular biomarkers
Survival prediction in gliomas based on MRI radiomics combined with clinical factors and molecular biomarkers Open
Background To investigate the practicability of a radiomics signature combined with clinical factors and molecular biomarkers for predicting overall survival (OS) in glioma patients. Methods Training ( n = 331) and internal validation ( n …
View article: Predicting the molecular subtypes of 2021 WHO grade 4 glioma by a multiparametric MRI-based machine learning model
Predicting the molecular subtypes of 2021 WHO grade 4 glioma by a multiparametric MRI-based machine learning model Open
The multiparametric MRI ML model effectively distinguished astrocytoma, CNS WHO grade 4 from GBM, IDH-wt (WHO 2021) and differentiated astrocytoma, IDH-mut from astrocytoma, IDH-wt, CNS WHO grade 4. Additionally, the model provided reliabl…
View article: Genomic investigation of a non-travel Plasmodium falciparum case linked to imported malaria in China’s post-elimination era
Genomic investigation of a non-travel Plasmodium falciparum case linked to imported malaria in China’s post-elimination era Open
Genomic tools such as WGS, PCA, and IBD analysis can enhance national malaria surveillance systems by identifying infection sources and clarifying transmission routes. Their integration supports elimination-stage strategies and helps preve…
View article: POS0030 Exploring the clinical and social determinants of multiple drug failures in refractory rheumatoid arthritis
POS0030 Exploring the clinical and social determinants of multiple drug failures in refractory rheumatoid arthritis Open
View article: Correction: Chinese expert consensus on magnetic resonance enterography of the small intestine and standardized reporting guidelines: translation
Correction: Chinese expert consensus on magnetic resonance enterography of the small intestine and standardized reporting guidelines: translation Open
View article: Efficacy of Combined Conjoint Fascial Sheath and Levator Muscle Composite Flap Suspension for Recurrent Severe Ptosis
Efficacy of Combined Conjoint Fascial Sheath and Levator Muscle Composite Flap Suspension for Recurrent Severe Ptosis Open
Background Conjoint fascial sheath (CFS) and levator muscle (LM) composite flap suspension has been gradually accepted for the treatment of congenital severe blepharoptosis in recent years. This study is to evaluate the clinical efficacy o…
View article: MRI transformer deep learning and radiomics for predicting IDH wild type TERT promoter mutant gliomas
MRI transformer deep learning and radiomics for predicting IDH wild type TERT promoter mutant gliomas Open
View article: Alkaline Adjuvant Regulates Proteolytic Activity of Macrophages for Antigen Cross‐Presentation and Potentiates Radioimmunotherapy
Alkaline Adjuvant Regulates Proteolytic Activity of Macrophages for Antigen Cross‐Presentation and Potentiates Radioimmunotherapy Open
Failures of radiotherapy (RT) in adaptive antitumor immunomodulation often associate with recruited tissue‐repairing macrophages. Although training these macrophages to phagocytose post‐RT cancer cells reverses their protumoral performance…
View article: METTL3 stabilizes SERPINE2 via the m6A modification to drive the malignant progression of gastric signet ring cell carcinoma
METTL3 stabilizes SERPINE2 via the m6A modification to drive the malignant progression of gastric signet ring cell carcinoma Open
Our study defines the significant roles of the METTL3/SERPINE2 axis as an epigenetic mechanism in GSRCC progression. Our work may have diagnostic and/or therapeutic applications in GSRCC.
View article: Predicting benefit of post-radiotherapy chemotherapy in high-grade glioma: A 2.5D CNN-ViT fusion model integrating transformer and habitat-derived clustering labels
Predicting benefit of post-radiotherapy chemotherapy in high-grade glioma: A 2.5D CNN-ViT fusion model integrating transformer and habitat-derived clustering labels Open
View article: Predicting the Molecular Subtypes of 2021 WHO Grade 4 Glioma by a Multiparametric MRI-Based Machine Learning Model
Predicting the Molecular Subtypes of 2021 WHO Grade 4 Glioma by a Multiparametric MRI-Based Machine Learning Model Open
Purpose: To develop and validate a machine learning (ML) model using multiparametric MRI for the preoperative differentiation of 2021 World Health Organization (WHO) grade 4 astrocytoma and glioblastoma (GBM) (Task 1), and to stratify grad…
View article: Multi-sequence MRI-based radiomics model to preoperatively predict the WHO/ISUP grade of clear Cell Renal Cell Carcinoma: a two-center study
Multi-sequence MRI-based radiomics model to preoperatively predict the WHO/ISUP grade of clear Cell Renal Cell Carcinoma: a two-center study Open
The radiomics models based on multi-sequence MRI might be a noninvasive and effective tool, demonstrating good efficacy in preoperatively predicting the WHO/ISUP grade of ccRCC.
View article: Fecal microbiota transplantation promotes immunotherapy sensitivity in refractory gastrointestinal cancer patients: open label, single-arm, single center, phase 1 study
Fecal microbiota transplantation promotes immunotherapy sensitivity in refractory gastrointestinal cancer patients: open label, single-arm, single center, phase 1 study Open
Background The discovery and therapeutic application of immune checkpoint inhibitors (ICIs) has significantly improved clinical outcomes in cancer treatment. However, the response rate is still low in gastrointestinal (GI) cancers. The gut…
View article: ANCIENT SCHWANNOMA
ANCIENT SCHWANNOMA Open
INTRODUCTION/BACKGROUND Retroperitoneal schwannoma is a benign neoplasm arising from the neural crest cells. Pre-operative diagnosis of this rare tumour is often difficult due to its enormous size at the time of presentation and the lack o…
View article: Diffusion kurtosis imaging‐based habitat analysis identifies high‐risk molecular subtypes and heterogeneity matching in diffuse gliomas
Diffusion kurtosis imaging‐based habitat analysis identifies high‐risk molecular subtypes and heterogeneity matching in diffuse gliomas Open
Objective High‐risk types of diffuse gliomas in adults include isocitrate dehydrogenase (IDH) wild‐type glioblastomas and grade 4 astrocytomas. Achieving noninvasive prediction of high‐risk molecular subtypes of gliomas is important for pe…
View article: Human-derived fecal microbiota transplantation alleviates mitochondrial dysfunction and social deficits in the BTBR mouse model for autism
Human-derived fecal microbiota transplantation alleviates mitochondrial dysfunction and social deficits in the BTBR mouse model for autism Open
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by social communication deficiencies and stereotypic behaviors influenced by hereditary and/or environmental risk factors. There are currently no …
View article: <i>Eubacterium rectale</i>is a potential marker of altered gut microbiota in psoriasis and psoriatic arthritis
<i>Eubacterium rectale</i>is a potential marker of altered gut microbiota in psoriasis and psoriatic arthritis Open
Previous studies have profiled the gut microbiota among psoriatic patients compared to that among healthy individuals. However, a comprehensive understanding of the magnitude, direction, and detailed compositional and functional profiles r…
View article: Investigative Radiogenomic Analysis of Gliomas by Combining miRNA Profiles and Functional MRI
Investigative Radiogenomic Analysis of Gliomas by Combining miRNA Profiles and Functional MRI Open
View article: Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy
Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy Open
Despite the encouraging efficacy of anti-PD-1/PD-L1 immunotherapy in microsatellite-instability-high/deficient mismatch repair (MSI-H/dMMR) advanced gastrointestinal cancer, many patients exhibit primary or acquired resistance. Using multi…
View article: LncRNA LINC01671/YY1 positive feedback loop induced EMT modulates CCL2 secretion in colorectal cancer to attract M2-like TAM infiltration
LncRNA LINC01671/YY1 positive feedback loop induced EMT modulates CCL2 secretion in colorectal cancer to attract M2-like TAM infiltration Open
Background Epithelial-mesenchymal transition (EMT) is involved in the interaction between cancer cells and tumor-associated macrophages (TAMs) in the tumor microenvironment (TME), which intimately affects tumorigenicity and metastasis. How…
View article: Characteristics of gut microbiota in patients with metabolic associated fatty liver disease
Characteristics of gut microbiota in patients with metabolic associated fatty liver disease Open
Metabolic associated fatty liver disease (MAFLD) is rising in incidence and is an increasingly common cause of cirrhosis and hepatocellular carcinoma (HCC). Alterations in the gut microbiota have been shown to correlate with the developmen…
View article: POS0014 SINGLE-CELL PERIPHERAL BLOOD ANALYSIS IDENTIFIES KEY IMMUNE SIGNATURES ASSOCIATED WITH REFRACTORY RHEUMATOID ARTHRITIS
POS0014 SINGLE-CELL PERIPHERAL BLOOD ANALYSIS IDENTIFIES KEY IMMUNE SIGNATURES ASSOCIATED WITH REFRACTORY RHEUMATOID ARTHRITIS Open
View article: Correlation of the gut microbiome and immune-related adverse events in gastrointestinal cancer patients treated with immune checkpoint inhibitors
Correlation of the gut microbiome and immune-related adverse events in gastrointestinal cancer patients treated with immune checkpoint inhibitors Open
Introduction The wide application of immune checkpoint inhibitors has significantly improved the survival expectation of cancer patients. While immunotherapy brings benefits to patients, it also results in a series of immune-related advers…
View article: Multi-omics analyses revealed the effect of fecal microbiota transplantation on alleviating mitochondrial dysfunctions and social deficits in a mouse model of ASD
Multi-omics analyses revealed the effect of fecal microbiota transplantation on alleviating mitochondrial dysfunctions and social deficits in a mouse model of ASD Open
Background: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder defined by social communication deficiencies and stereotypic behaviors caused by hereditary and environmental risk factors. There ar…
View article: Multi-omics analyses revealed the effect of fecal microbiota transplantation on alleviating mitochondrial dysfunctions and social deficits in a mouse model of ASD
Multi-omics analyses revealed the effect of fecal microbiota transplantation on alleviating mitochondrial dysfunctions and social deficits in a mouse model of ASD Open
Background: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder defined by social communication deficiencies and stereotypic behaviors caused by hereditary and environmental risk factors. There ar…
View article: Prediction of the Molecular Subtype of IDH Mutation Combined with MGMT Promoter Methylation in Gliomas via Radiomics Based on Preoperative MRI
Prediction of the Molecular Subtype of IDH Mutation Combined with MGMT Promoter Methylation in Gliomas via Radiomics Based on Preoperative MRI Open
Background: The molecular subtype of IDH mut combined with MGMT meth in gliomas suggests a good prognosis and potential benefit from TMZ chemotherapy. The aim of this study was to establish a radiomics model to predict this molecular subty…