Yejin Kang
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View article: Assessment of Clinical Factors that Predict Response to Nabilone for Agitation in Alzheimer's Disease: A Post Hoc Analysis of a Randomized Control Trial
Assessment of Clinical Factors that Predict Response to Nabilone for Agitation in Alzheimer's Disease: A Post Hoc Analysis of a Randomized Control Trial Open
Background Agitation is one of the most prevalent neuropsychiatric symptoms (NPS) of Alzheimer's disease (AD). A crossover trial of nabilone for agitation in AD found that nabilone was effective in treating agitation. We aimed to identify …
View article: Antioxidant <i>N</i> ‐acetylcysteine as an intervention for neuropsychiatric symptoms in individuals with vascular mild cognitive impairment
Antioxidant <i>N</i> ‐acetylcysteine as an intervention for neuropsychiatric symptoms in individuals with vascular mild cognitive impairment Open
Background Neuropsychiatric symptoms (NPS) are non‐cognitive changes that often co‐occur with mild cognitive impairment (MCI) and independently increase the risk of progression to dementia. Of the NPS, apathy is a particularly strong risk …
View article: Efficacy and safety of N‐acetylcysteine in patients with vascular mild cognitive impairment (vMCI): Memory and antioxidant in vMCI Exercise Intervention Trial (MOVE‐IT)
Efficacy and safety of N‐acetylcysteine in patients with vascular mild cognitive impairment (vMCI): Memory and antioxidant in vMCI Exercise Intervention Trial (MOVE‐IT) Open
Background Oxidative stress (OS) is implicated in the etiology of vascular mild cognitive impairment (vMCI), a form of cognitive decline originating from cerebrovascular pathology. vMCI is characterized by early deficits in executive funct…
View article: Heterogeneity in response to N‐acetylcysteine in vascular mild cognitive impairment
Heterogeneity in response to N‐acetylcysteine in vascular mild cognitive impairment Open
Background Oxidative stress (OS) plays a significant role in vascular mild cognitive impairment (vMCI), and the antioxidant N‐acetylcysteine (NAC) was proposed to mitigate cognitive decline. However, our randomized clinical trial (NCT03306…
View article: Synaptic Biomarkers in Alzheimer's Dementia: A Meta‐Analysis
Synaptic Biomarkers in Alzheimer's Dementia: A Meta‐Analysis Open
Background Alzheimer's dementia (AD) is a neurodegenerative condition characterized by progressive cognitive decline. Synaptopathy—defined as loss and dysfunction of existing synapses—is a hallmark pathological feature of AD and can direct…
View article: Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes
Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes Open
Background: Acute and chronic hyperglycemia in patients with type 2 diabetes mellitus (T2DM) causes endothelial dysfunction and arterial stiffness, contributing to early mortality from cardiovascular disease (CVD). Although L-citrulline (C…
View article: Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes
Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes Open
Background: Patients with type 2 diabetes (T2D) develop vascular complications due to arginine deficiency-induced microvascular endothelial dysfunction, which is related to the loss of muscle strength (MS) associated with aging. Thus, incr…
View article: MRS demonstrates elevated brain glutathione in vascular mild cognitive impairment compared to cognitively normal coronary artery disease controls
MRS demonstrates elevated brain glutathione in vascular mild cognitive impairment compared to cognitively normal coronary artery disease controls Open
INTRODUCTION Oxidative stress (OS) is implicated in dementia. While elevated peripheral OS biomarkers were observed in vascular mild cognitive impairment (vMCI), the role of central antioxidants remains unclear. We assessed levels of the m…
View article: Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis
Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis Open
Background and Aims Hypertension is the predominant modifiable cardiovascular risk factor. This cohort study assessed the association of risk with the percentage of time that the ambulatory blood pressure (ABP) is within the target range (…
View article: Brain glutathione in vascular mild cognitive impairment and cognitive correlates
Brain glutathione in vascular mild cognitive impairment and cognitive correlates Open
Background Oxidative stress (OS) has been implicated in age‐related neurodegeneration and may be important in prodromal states such as vascular mild cognitive impairment (vMCI). Higher peripheral OS is reported in vMCI patients; however, t…
View article: Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT)
Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT) Open
Background Oxidative stress (OS) has been a target of interest for vascular dementia, given its implications in pathogenesis. OS may be important in prodromal stage, such as vascular mild cognitive impairment (vMCI), and examining OS marke…
View article: L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women
L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women Open
Endothelial dysfunction decreases exercise limb blood flow (BF) and muscle oxygenation. Acute L-Citrulline supplementation (CIT) improves muscle tissue oxygen saturation index (TSI) and deoxygenated hemoglobin (HHb) during exercise. Althou…
View article: Oral L-Citrulline Supplementation Improves Fatty Liver and Dyslipidemia in Adolescents with Abdominal Obesity: A Parallel, Double-Blind, Randomized Clinical Trial
Oral L-Citrulline Supplementation Improves Fatty Liver and Dyslipidemia in Adolescents with Abdominal Obesity: A Parallel, Double-Blind, Randomized Clinical Trial Open
Obesity in adolescents is associated with non-communicable risk factors and diseases like metabolic-associated fatty liver disease (MAFLD), which is the liver manifestation of metabolic syndrome. L-citrulline is a non-protein amino acid th…
View article: L-Citrulline supplementation attenuates aortic pressure and pressure waves during metaboreflex activation in postmenopausal women
L-Citrulline supplementation attenuates aortic pressure and pressure waves during metaboreflex activation in postmenopausal women Open
Postmenopausal women have augmented pressure wave responses to low-intensity isometric handgrip exercise (IHG) due to an overactive metaboreflex (postexercise muscle ischaemia, PEMI), contributing to increased aortic systolic blood pressur…
View article: Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal Women
Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal Women Open
Postmenopausal women (PMW) may experience endothelial dysfunction associated with arginine (ARG) deficiency relative to asymmetric dimethylarginine (ADMA) caused by oxidative stress. Endothelial dysfunction contributes to increased blood p…
View article: Combined L-Citrulline Supplementation and Slow Velocity Low-Intensity Resistance Training Improves Leg Endothelial Function, Lean Mass, and Strength in Hypertensive Postmenopausal Women
Combined L-Citrulline Supplementation and Slow Velocity Low-Intensity Resistance Training Improves Leg Endothelial Function, Lean Mass, and Strength in Hypertensive Postmenopausal Women Open
Hypertension is highly prevalent in postmenopausal women. Endothelial dysfunction is associated with hypertension and the age-related decreases in muscle mass and strength. L-citrulline supplementation (CIT) and slow velocity low-intensity…
View article: Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women
Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women Open
Aging and menopause are associated with decreased nitric oxide bioavailability due to reduced L-arginine (L-ARG) levels contributing to endothelial dysfunction (ED). ED precedes arterial stiffness and hypertension development, a major risk…
View article: Non-pharmacological Management of Non-productive Chronic Cough in Adults: A Systematic Review
Non-pharmacological Management of Non-productive Chronic Cough in Adults: A Systematic Review Open
Background Chronic cough is a common reason for medical referral and its prevalence is on the rise. With only one pharmaceutical therapy currently under review for the treatment of refractory chronic cough, exploring non-pharmacological ch…
View article: Acute Effect of Moderate-intensity Aerobic Exercise on Cerebral Blood Flow and Cognitive Function in Young Adults: Treadmill vs. Cycle Ergometer
Acute Effect of Moderate-intensity Aerobic Exercise on Cerebral Blood Flow and Cognitive Function in Young Adults: Treadmill vs. Cycle Ergometer Open
PURPOSE: This study aimed to compare the acute effects of different types (treadmill vs. cycle) of moderate-intensity aerobic exercise on cerebral blood flow and cognitive function in young adults.METHODS: By a randomized crossover study d…
View article: Acute Effect of Moderate-intensity Aerobic Exercise on Cerebral Blood Flow and Cognitive Function in Young Adults: Treadmill vs. Cycle Ergometer
Acute Effect of Moderate-intensity Aerobic Exercise on Cerebral Blood Flow and Cognitive Function in Young Adults: Treadmill vs. Cycle Ergometer Open
PURPOSE: This study aimed to compare the acute effects of different types (treadmill vs. cycle) of moderate-intensity aerobic exercise on cerebral blood flow and cognitive function in young adults.METHODS: By a randomized crossover study d…
View article: The Relationship between Physical Activity Level and Arterial Stiffness in Young Female Adults
The Relationship between Physical Activity Level and Arterial Stiffness in Young Female Adults Open
PURPOSE Arterial stiffness is associated with cardiovascular events and mortality. Regular physical activity contributes to decrease in arterial stiffness. The purpose of this study was to analyze the relationship between physical activity…