Yelena Guttman
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View article: Computer-Aided (In Silico) Modeling of Cytochrome P450-Mediated Food–Drug Interactions (FDI)
Computer-Aided (In Silico) Modeling of Cytochrome P450-Mediated Food–Drug Interactions (FDI) Open
Modifications of the activity of Cytochrome 450 (CYP) enzymes by compounds in food might impair medical treatments. These CYP-mediated food–drug interactions (FDI) play a major role in drug clearance in the intestine and liver. Inter-indiv…
View article: Dietary Inhibitors of CYP3A4 Are Revealed Using Virtual Screening by Using a New Deep-Learning Classifier
Dietary Inhibitors of CYP3A4 Are Revealed Using Virtual Screening by Using a New Deep-Learning Classifier Open
CYP3A4 is the main human enzyme responsible for phase I metabolism of dietary compounds, prescribed drugs and xenobiotics, steroid hormones, and bile acids. The inhibition of CYP3A4 activity might impair physiological mechanisms, including…
View article: Zantedeschia - partial sequences
Zantedeschia - partial sequences Open
Partial sequences of defense related genes (cDNA) of Zantedeschia (Calla lily): Aspartate aminotransferase (ast)Phenylalanine ammonia lyase (pal)Pathogenesis related protein 1 (pr1)Lipoxygenase2 (lox2)
View article: Ecological adaptations influence the susceptibility of plants in the genus Zantedeschia to soft rot Pectobacterium spp.
Ecological adaptations influence the susceptibility of plants in the genus Zantedeschia to soft rot Pectobacterium spp. Open
Soft rot disease caused by Pectobacterium spp. is responsible for severe agricultural losses in potato, vegetables, and ornamentals. The genus Zantedeschia includes two botanical groups of tuberous ornamental flowers that are highly suscep…
View article: New grapefruit cultivars exhibit low cytochrome P4503A4-Inhibition activity
New grapefruit cultivars exhibit low cytochrome P4503A4-Inhibition activity Open
Furanocoumarins are the main compounds responsible for the food-drug interactions known as the grapefruit effect, which is caused by the inhibition of CYP3A4-mediated drug metabolism. We evaluated the effects of two new, low-furanocoumarin…
View article: Polymorphism in Cytochrome P450 3A4 Is Ethnicity Related
Polymorphism in Cytochrome P450 3A4 Is Ethnicity Related Open
Can mutations in Cytochrome P450 3A4 (CYP3A4), the major food- and drug-metabolizing enzyme, serve as biomarkers for personalized precise medicine? Classical genetic studies provide only limited data regarding the frequencies of CYP3A4 mut…