Yeli Wang
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View article: Comparative evaluation of a hybrid machine learning-human adjudication paradigm for endoscopic scoring in ulcerative colitis
Comparative evaluation of a hybrid machine learning-human adjudication paradigm for endoscopic scoring in ulcerative colitis Open
Objective Endoscopic scoring of disease activity is essential in ulcerative colitis trials but is limited by inter-reader variability and operational complexity. We evaluated a novel central reading paradigm integrating two independently d…
View article: Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies
Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies Open
Objective: To prospectively examine associations between five low-carbohydrate diets (LCDs), differentiated by macronutrient quality, and type 2 diabetes (T2D) risk.Research Design and Methods: This cohort study included 199,006 U.S. adult…
View article: Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies
Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies Open
Objective: To prospectively examine associations between five low-carbohydrate diets (LCDs), differentiated by macronutrient quality, and type 2 diabetes (T2D) risk.Research Design and Methods: This cohort study included 199,006 U.S. adult…
View article: [Retracted] MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway
[Retracted] MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway Open
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the scratch wound assay experiments shown in Fig. 2A and the cell invasion assay experiments shown in Figs. 2B and 7…
View article: Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8 <sup>+</sup> T cells by granzyme B and perforin
Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8 <sup>+</sup> T cells by granzyme B and perforin Open
ST8Sia1 is a potential diagnostic biomarker and therapeutic target for READ, enhancing CD8+ T cell function and possibly improving patient outcomes through cellular immunotherapy.
View article: Inter- and Intraobserver Variability on Endoscopic Scoring Systems in Crohn’s Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis
Inter- and Intraobserver Variability on Endoscopic Scoring Systems in Crohn’s Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis Open
Background Endoscopy scoring is a key component in the diagnosis of ulcerative colitis (UC) and Crohn’s disease (CD). Variability in endoscopic scoring can impact patient trial eligibility and treatment effect measurement. In this study, w…
View article: Discordance Between Creatinine-Based and Cystatin C–Based Estimated GFR: Interpretation According to Performance Compared to Measured GFR
Discordance Between Creatinine-Based and Cystatin C–Based Estimated GFR: Interpretation According to Performance Compared to Measured GFR Open
Discordant eGFRcr and eGFRcys are common. eGFR using the combination of creatinine and cystatin C provides the most accurate estimates among persons with discordant eGFRcr or eGFRcys.
View article: Knowledge of COVID-19 and associated factors among kidney transplant recipients and donors in Singapore
Knowledge of COVID-19 and associated factors among kidney transplant recipients and donors in Singapore Open
Background: Effective interventions during the coronavirus disease 2019 (COVID-19) pandemic require an understanding of patients’ knowledge and perceptions that influence their behaviour. Our study assessed knowledge of COVID-19 among kidn…
View article: Performance of Serum β2-Microglobulin– and β-Trace Protein–Based Panel Markers and 2021 Creatinine- and Cystatin-Based GFR Estimating Equations in Pakistan
Performance of Serum β2-Microglobulin– and β-Trace Protein–Based Panel Markers and 2021 Creatinine- and Cystatin-Based GFR Estimating Equations in Pakistan Open
Estimating glomerular filtration rate (GFR) using the creatinine-based equation (eGFRcr) as an initial test and the cystatin C-based equations (eGFRcys or eGFRcr-cys) as a confirmatory test is recommended.1Summary of recommendation stateme…
View article: Psychological distress and associated factors among kidney transplant recipients and living kidney donors during COVID-19
Psychological distress and associated factors among kidney transplant recipients and living kidney donors during COVID-19 Open
Background The coronavirus disease 2019 (COVID-19) pandemic has caused significant psychological distress globally. Our study assessed the prevalence of psychological distress and associated factors during COVID-19 pandemic among kidney tr…
View article: Chronic kidney disease biomarkers and mortality among older adults: A comparison study of survey samples in China and the United States
Chronic kidney disease biomarkers and mortality among older adults: A comparison study of survey samples in China and the United States Open
Objectives Among older adults in China and the US, we aimed to compare the biomarkers of chronic-kidney-diseases (CKD), factors associated with CKD, and the correlation between CKD and mortality. Setting China and the US. Study design Cros…
View article: Whole Brain Mapping of Neurons Innervating Extraorbital Lacrimal Glands in Mice and Rats of Both Genders
Whole Brain Mapping of Neurons Innervating Extraorbital Lacrimal Glands in Mice and Rats of Both Genders Open
The extraorbital lacrimal glands (ELGs) secret tears to maintain a homeostatic environment for ocular surfaces, and pheromones to mediate social interactions. Although its distinct gender-related differences in mice and rats have been iden…
View article: Visceral fat area is the measure of obesity best associated with mobility disability in community dwelling oldest-old Chinese adults
Visceral fat area is the measure of obesity best associated with mobility disability in community dwelling oldest-old Chinese adults Open
Background Although obesity can be clinically defined by body mass index (BMI), waist circumference, percent body fat, or visceral fat area, it is unclear which specific measure is best associated with mobility disability in oldest-old adu…
View article: Performance and Determinants of Serum Creatinine and Cystatin C–Based GFR Estimating Equations in South Asians
Performance and Determinants of Serum Creatinine and Cystatin C–Based GFR Estimating Equations in South Asians Open
eGFRcys underestimated mGFR in South Asians and eGFRcr-cys did not offer substantial advantage compared with eGFRcr-PK. Future studies are warranted to better understand the large bias in eGFRcys and non-GFR determinants of cystatin C in S…
View article: Factors associated with psychological distress during the coronavirus disease 2019 (COVID-19) pandemic on the predominantly general population: A systematic review and meta-analysis
Factors associated with psychological distress during the coronavirus disease 2019 (COVID-19) pandemic on the predominantly general population: A systematic review and meta-analysis Open
Background The Coronavirus Disease 2019 (COVID-19) outbreak has escalated the burden of psychological distress. We aimed to evaluate factors associated with psychological distress among the predominantly general population during the COVID…
View article: Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study
Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study Open
Background: Epidemiological studies have demonstrated separately that patients with kidney stone may have higher dietary intake of zinc and higher risk of developing kidney cancer. We prospectively assessed the associations of dietary zinc…
View article: Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population
Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population Open
Introduction The non-invasive enhanced liver fibrosis (ELF) score—comprising tissue inhibitor of matrix metalloproteinases-1 (TIMP1), hyaluronic acid (HA) and amino-terminal propeptide of type III procollagen (PIIINP)—has been shown to acc…
View article: Multiple Biomarkers Improved Prediction for the Risk of Type 2 Diabetes Mellitus in Singapore Chinese Men and Women
Multiple Biomarkers Improved Prediction for the Risk of Type 2 Diabetes Mellitus in Singapore Chinese Men and Women Open
A composite score of blood biomarkers improved T2DM risk prediction among Chinese.
View article: Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women
Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women Open
Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adip…
View article: MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway
MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway Open
MicroRNAs (miRNAs) play a vital role in the progression of cancer, however, only limited data on miRNAs in rectal cancer are available. The aim of the present study was to investigate whether miR‑195 could inhibit the progression of rectal…
View article: Adiposity measures and pre‐diabetes or diabetes in adults with hypertension in Singapore polyclinics
Adiposity measures and pre‐diabetes or diabetes in adults with hypertension in Singapore polyclinics Open
Identification of hypertensive patients with pre‐diabetes or diabetes is important for timely prevention of complications including vascular disease. We aimed to compare the association and discrimination of central obesity measures (waist…
View article: Associations of Plasma CD36 and Body Fat Distribution
Associations of Plasma CD36 and Body Fat Distribution Open
Context CD36 is a class B scavenger-receptor involved in the uptake of fatty acids in liver and adipose tissue. It is unknown whether plasma CD36 levels are related to liver fat content or adipose tissue in the general population. Methods …