Yeling Ma
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View article: Dynamic Spiral Artery Remodeling in Early Human Pregnancy: An Analysis of Specimens Collected with a Standardized Protocol
Dynamic Spiral Artery Remodeling in Early Human Pregnancy: An Analysis of Specimens Collected with a Standardized Protocol Open
Human uterine spiral artery remodeling (SAR) is a tightly regulated process involving complex interactions between interstitial and endovascular extravillous trophoblasts (iEVTs and enEVTs) and diverse maternal decidual cell populations. H…
View article: Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancy
Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancy Open
During human pregnancy, a certain proportion of endothelial cells in uterine spiral arteries are replaced by placental extravillous trophoblasts (EVTs). This process is a pivotal step in spiral artery remodeling (SAR), ensuring the adequat…
View article: Potential pathological mechanisms and pharmacological interventions for cadmium-induced miscarriage
Potential pathological mechanisms and pharmacological interventions for cadmium-induced miscarriage Open
The prevalence of cadmium (Cd) contamination has emerged as a significant global concern. Exposure to Cd during pregnancy is associated with adverse pregnancy outcomes, including miscarriage. However, there is currently a lack of comprehen…
View article: Effectiveness of Scutellaria baicalensis Georgi root in pregnancy-related diseases: A review
Effectiveness of Scutellaria baicalensis Georgi root in pregnancy-related diseases: A review Open
The root of Scutellaria baicalensis Georgi, also called Huangqin, is frequently used in traditional Chinese medicine. In ancient China, S. baicalensis root was used to clear heat, protect the fetus, and avoid a miscarriage for thousands of…
View article: Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia
Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia Open
Background Preeclampsia (PE), a placenta-associated pregnancy complication, is the leading cause of maternal and perinatal morbidity and mortality. Met/Erk signaling is inhibited in the placentas of patients with early-onset preeclampsia (…
View article: MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness
MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness Open
Objectives Success in pregnancy in mammals predominantly depends on a well‐developed placenta. The differentiation of invasive trophoblasts is a fundamental process of placentation, the abnormalities of which are tightly associated with pr…
View article: Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy
Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy Open
In placental mammals, reproductive success, and maternal-fetal health substantially depend on a well-being placenta, the interface between the fetus and the mother. Disorders in placental cells are tightly associated with adverse pregnancy…
View article: Single-Cell Immune Landscape of Human Recurrent Miscarriage
Single-Cell Immune Landscape of Human Recurrent Miscarriage Open
Successful pregnancy in placental mammals substantially depends on the establishment of maternal immune tolerance to the semi-allogenic fetus. Disorders in this process are tightly associated with adverse pregnancy outcomes including recur…
View article: HGF/c-Met signaling regulates early differentiation of placental trophoblast cells
HGF/c-Met signaling regulates early differentiation of placental trophoblast cells Open
Depletion of hepatocyte growth factor (HGF) or mesenchymal-epithelial transition factor (c-Met) in mice leads to fetal lethality and placental maldevelopment. However, the dynamic change pattern of HGF/c-Met signaling during placental deve…
View article: Uterine scarring leads to adverse pregnant consequence through impairing the response of endometrium to steroids
Uterine scarring leads to adverse pregnant consequence through impairing the response of endometrium to steroids Open
Uterine surgical scarring is an increasing risk factor for adverse pregnant consequences that threaten fetal-maternal health. The detailed molecular features of scar implantation remain largely unknown. We aim to study the pathologic featu…
View article: Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids
Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids Open
Uterine surgical scarring is an increasing risk factor for adverse pregnant consequences that threaten fetal-maternal health. The detailed molecular features of scar implantation remain largely unknown. We aim to study the pathologic featu…
View article: Single-cell immune landscape of human recurrent spontaneous abortion
Single-cell immune landscape of human recurrent spontaneous abortion Open
SUMMARY Successful pregnancy in placental mammals substantially depends on the establishment of maternal immune tolerance to the semi-allogenic fetus. Disorders in this process are tightly associated with adverse pregnancy outcomes includi…
View article: Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T‐cell differentiation along the maternal‐placental circulation
Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T‐cell differentiation along the maternal‐placental circulation Open
Objectives During human pregnancy, the endothelial cells of the uterine spiral arteries (SPA) are extensively replaced by a subtype of placental trophoblasts, endovascular extravillous trophoblasts (enEVTs), thus establishing a placental‐m…