Yen‐Wen Chen
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View article: The concentration-dependent protective effects by new generation hypoglycemic agents on delirium, depression, dementia and coma: evidence from a network meta-analysis
The concentration-dependent protective effects by new generation hypoglycemic agents on delirium, depression, dementia and coma: evidence from a network meta-analysis Open
Objectives: Emerging evidence suggests that glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose co-transporter 2 (SGLT2) inhibitors may exert neuroprotective effects. However, the comparative efficacy of individual agents …
View article: Audiovestibular Dysfunction in Hyper-IgE Syndrome: A Systematic Review of Characteristics, Pathophysiology, Diagnosis, and Management
Audiovestibular Dysfunction in Hyper-IgE Syndrome: A Systematic Review of Characteristics, Pathophysiology, Diagnosis, and Management Open
Hyper-IgE syndrome (HIES) is a rare genetic immunodeficiency characterized by elevated serum IgE levels and associated immune dysregulation, manifesting in recurrent infections, eczema, and skeletal abnormalities. Emerging evidence suggest…
View article: The different colorectal tumor risk related to GLP-1 receptor agonists and SGLT2 inhibitors use: a network meta-analysis of 68 randomized controlled trials
The different colorectal tumor risk related to GLP-1 receptor agonists and SGLT2 inhibitors use: a network meta-analysis of 68 randomized controlled trials Open
Background: Recent evidence has raised concerns about potential pro-oncogenic effects associated with glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose co-transporter 2 (SGLT2) inhibitors, particularly regarding gastroin…
View article: The Preventive Effects of GLP-1 Receptor Agonists and SGLT2 Inhibitors on Cancer Metastasis: A Network Meta-Analysis of 67 Randomized Controlled Trials
The Preventive Effects of GLP-1 Receptor Agonists and SGLT2 Inhibitors on Cancer Metastasis: A Network Meta-Analysis of 67 Randomized Controlled Trials Open
Metastatic cancer, characterized by poor survival outcomes and grim prognosis, represents the final stage of malignancy. The current evidence regarding the prophylactic effects of glucagon-like peptide-1 (GLP-1) receptor agonists and sodiu…
View article: Potential placebo bias in current trials of delirium prevention: a network meta‐analysis of 86 randomized controlled trials
Potential placebo bias in current trials of delirium prevention: a network meta‐analysis of 86 randomized controlled trials Open
Aim Numerous network meta‐analyses (NMAs) have reported inconsistent findings on the efficacy of various pharmacologic treatments for delirium prevention in high‐risk patients. A potential confounder was the study design—using a placebo co…
View article: Audiovestibular Dysfunction in Patients with Hashimoto’s Disease: A Systematic Review
Audiovestibular Dysfunction in Patients with Hashimoto’s Disease: A Systematic Review Open
Although the inner ear is considered an immune-privileged organ because of the blood–labyrinth barrier, accumulating evidence has revealed an unexpected relation between Hashimoto’s disease and inner ear damage manifesting as audiovestibul…
View article: The Efficacy and Acceptability of Non‐Invasive Brain Stimulation Interventions for Obsessive‐Compulsive Disorder Management: A Network Meta‐Analysis Based on 24 Stimulation Methods
The Efficacy and Acceptability of Non‐Invasive Brain Stimulation Interventions for Obsessive‐Compulsive Disorder Management: A Network Meta‐Analysis Based on 24 Stimulation Methods Open
Introduction Despite the high lifetime prevalence and elevated disability rates, treatments for obsessive‐compulsive disorder (OCD) have limited efficacy. Considering the abnormal connectivity in the cortical‐striatal‐thalamic‐cortical loo…
View article: Audiological Features in Patients with Rheumatoid Arthritis: A Systematic Review
Audiological Features in Patients with Rheumatoid Arthritis: A Systematic Review Open
Hearing impairment in patients with rheumatoid arthritis has been underestimated for decades. Rheumatoid arthritis can affect both the middle ear (specifically, the incudomalleolar and incudostapedial joints) and inner ear (including the c…
View article: Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review
Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review Open
Background: Anti-phospholipid syndrome (APS) has emerged as a significant issue in autoimmune diseases over recent decades. Its hallmark feature is thromboembolic events, potentially affecting any vascularized area including the microcircu…
View article: Turning Crises into Business Opportunities: An Exploratory Investigation of Customers’ Pain Points in the Automobile Maintenance Industry Based on a Computer Database
Turning Crises into Business Opportunities: An Exploratory Investigation of Customers’ Pain Points in the Automobile Maintenance Industry Based on a Computer Database Open
Companies need to decrease service failures through service recovery and by managing customers’ emotions, which is important. Customer databases are vital to understand needs and service innovation. Utilizing data, companies can identify p…
View article: Audiovestibular Dysfunction in Systemic Lupus Erythematosus Patients: A Systematic Review
Audiovestibular Dysfunction in Systemic Lupus Erythematosus Patients: A Systematic Review Open
Audiovestibular dysfunction in patients with systemic lupus erythematosus has been underestimated for decades. Systemic lupus erythematosus can affect both the auditory and vestibular systems simultaneously. Several potential pathophysiolo…
View article: Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials
Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials Open
The prevalence of pediatric constipation ranges from 0.7 to 29.6% across different countries. Functional constipation accounts for 95% of pediatric constipation, and the efficacy of pharmacotherapy is limited, with a success rate of 60%. S…
View article: Detection of Rabies Virus in a Yellow-Throated Marten (Martes flavigula chrysospila) in Taiwan
Detection of Rabies Virus in a Yellow-Throated Marten (Martes flavigula chrysospila) in Taiwan Open
In June 2021, a yellow-throated marten (Martes flavigula chrysospila) submitted for postmortem examination was diagnosed as rabid through laboratory testing. The rabies virus detected was closest phylogenetically to viruses of ferret badge…
View article: The difference in all-cause mortality between COVID-19 patients treated with standard of care plus placebo and those treated with standard of care alone: a network meta-analysis of randomised controlled trials of immunomodulatory kinase inhibitors
The difference in all-cause mortality between COVID-19 patients treated with standard of care plus placebo and those treated with standard of care alone: a network meta-analysis of randomised controlled trials of immunomodulatory kinase inhibitors Open
Objectives The aim of this network meta-analysis (NMA) was to assess whether participants assigned to a placebo and standard of care (SoC) group had different major coronavirus disease 2019 (COVID-19)-related outcomes than those assigned t…
View article: Retrospective analysis of aesthetic medical malpractice in mediation proceeding: A single‐court experience
Retrospective analysis of aesthetic medical malpractice in mediation proceeding: A single‐court experience Open
Recently, the number of aesthetic procedures has exponentially increased worldwide. Over 1.56 million surgical and 5.5 million nonsurgical aesthetic procedures were performed in the United States in 2021.1 However, the occurrence of mishap…
View article: EVALUATION OF A METAGENOMIC NEXT-GENERATION SEQUENCING ASSAY WITH A NOVEL HOST DEPLETION METHOD FOR PATHOGEN IDENTIFICATION IN SEPTIC PATIENTS
EVALUATION OF A METAGENOMIC NEXT-GENERATION SEQUENCING ASSAY WITH A NOVEL HOST DEPLETION METHOD FOR PATHOGEN IDENTIFICATION IN SEPTIC PATIENTS Open
Background The traditional diagnosis of sepsis has always been based on microbial blood culture (BC). However, BC suffers from (1) long culture cycle, leading to delay in results, and (2) low diagnostic yields. Metagenomic next-generation …
View article: The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials
The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials Open
Background Dementia [i.e., Alzheimer disease (AD)], the most common neurodegenerative disease, causes profound negative impacts on executive function and quality of life. Available pharmacological treatments often fail to achieve satisfact…
View article: The efficacy of exogenous melatonin supplement in ameliorating irritable bowel syndrome severity: A meta-analysis of randomized controlled trials
The efficacy of exogenous melatonin supplement in ameliorating irritable bowel syndrome severity: A meta-analysis of randomized controlled trials Open
PROSPERO CRD42021269451.
View article: Unmet need in major depressive disorder and acute suicidal ideation or behavior: findings from a longitudinal electronic health record data analysis
Unmet need in major depressive disorder and acute suicidal ideation or behavior: findings from a longitudinal electronic health record data analysis Open
This analysis highlights an opportunity to improve outcomes for this vulnerable population. More complete data on patient outcomes is needed to inform strategies designed to optimize screening and treatment.
View article: Occurrence of Thromboembolic Events and Mortality Among Hospitalized Coronavirus 2019 Patients: Large Observational Cohort Study of Electronic Health Records
Occurrence of Thromboembolic Events and Mortality Among Hospitalized Coronavirus 2019 Patients: Large Observational Cohort Study of Electronic Health Records Open
Background Most symptoms of coronavirus 2019 (COVID-19) are mild; however, some patients experience cardiovascular complications, including thromboembolic events and death. Data are needed to better inform prevention and treatment of these…
View article: Author Correction: Antidepressants during and after Menopausal Transition: A Systematic Review and Meta-Analysis
Author Correction: Antidepressants during and after Menopausal Transition: A Systematic Review and Meta-Analysis Open
In Figure 2, the data corresponding to the low-dose Desvenlafaxine (100 mg/day) and high-dose Desvenlafaxine (150 mg/day) treatment arms of Cheng, 2013 were not labelled.The original Figure 2 and accompanying legend appear below.Additional…
View article: Novel Bat Lyssaviruses Identified by Nationwide Passive Surveillance in Taiwan, 2018–2021
Novel Bat Lyssaviruses Identified by Nationwide Passive Surveillance in Taiwan, 2018–2021 Open
Bat lyssaviruses were identified in Taiwan’s bat population during 2016–2017. The lyssavirus surveillance system was continuously conducted to understand the epidemiology. Through this system, the found dead bats were collected for lyssavi…
View article: Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia
Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia Open
In this network meta-analysis, excitatory NIBS protocols over the left dorsolateral prefrontal cortex were associated with significantly large improvements in the severity of negative symptoms. Because relatively few studies were available…
View article: Changes in Periodic Limb Movements of Sleep After the Use of Continuous Positive Airway Pressure Therapy: A Meta-Analysis
Changes in Periodic Limb Movements of Sleep After the Use of Continuous Positive Airway Pressure Therapy: A Meta-Analysis Open
Background Both obstructive sleep apnea (OSA) and periodic limb movements of sleep (PLMS) are common in the sleep laboratory. The severity of OSA can be improved by using continuous positive airway pressure (CPAP). However, increasing evid…