Explanipedia

Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms Open

Santiago Elizondo-Benedetto, Sergio Sastriques-Dunlop, Lisa Detering, Batool Arif, Gyu Seong Heo , et al. · 2025

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a high mortality upon rupture. There is no diagnosis to predict the rupture nor effective medical therapies to prevent rupture. Here we demonstrate that the C-C chemok…

Longitudinal multimodal neuroimaging after traumatic brain injury Open

Ana Radanovic, Keith Jamison, Yeona Kang, Saleh Shah, Amy Kuceyeski · 2025

Traumatic brain injury is a major cause of long-term cognitive impairment, yet the mechanisms underlying recovery remain poorly understood. Neuroimaging methods such as diffusion MRI, functional MRI, and positron emission tomography (PET) …

Validating the Utility of Supervised Clustering Algorithm for Precise [11C]DPA-713 PET Brain Image Quantification Open

Youjin Lee, Thanh D. Nguyen, Yong Du, Jennifer M. Coughlin, Sara A. Zein , et al. · 2025

The reliance of quantitative PET imaging on the arterial input function makes brain PET challenging to perform in certain populations, limiting the sample size. To address this challenge, a supervised clustering algorithm (SVCA) has been i…

TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis Open

Ceren Tozlu, Keith Jamison, Yeona Kang, Sandra Hurtado Rúa, Ulrike W. Kaunzner , et al. · 2025

Objective To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation in PRL-disrupted WM tracts is associated with disability in people with multiple …

Investigation of [11C]carfentanil for mu opioid receptor quantification in the rat brain Open

Andrew Kelleher, Torben D. Pearson, J Tyler Ramsey, Wenjing Zhao, Kelly A. O’Conor , et al. · 2024

Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography Open

Tracy Butler, Julia Schubert, Nicolas A. Karakatsanis, Xiuyuan Hugh Wang, Ke Xi , et al. · 2024

Brain fluid clearance by pathways including the recently described paravascular glymphatic system is a critical homeostatic mechanism by which metabolic products, toxins, and other wastes are removed from the brain. Brain fluid clearance m…

Extended-Release Pre-exposure Prophylaxis and Drug-Resistant HIV Open

Yanping Ma, Yeona Kang, Angelica A. Davenport, Jennifer Mawunyo Aduamah, Kathryn G. Link , et al. · 2024

The pharmacologic tail of long-acting cabotegravir (CAB-LA), an injectable pre-exposure prophylaxis (PrEP), allows for months-long intervals between injections, but it may facilitate the emergence of drug-resistant human immunodeficiency v…

Chemokine Receptor 2 Is A Theranostic Biomarker for Abdominal Aortic Aneurysms Open

Santiago Elizondo-Benedetto, Sergio Sastriques-Dunlop, Lisa Detering, Batool Arif, Gyu Seong Heo , et al. · 2023

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease impacting aging populations with a high mortality upon rupture. There are no effective medical therapies to prevent AAA expansion and rupture. We previously demonstrated th…

Analysis of the Convolutional Neural Network Model in Detecting Brain Tumor Open

Destiny Rankins, Dewayne A. Dixon, Yeona Kang, Seonguk Kim · 2022

Detecting brain tumors is an active area of research in brain image processing. This paper proposes a methodology to segment and classify brain tumors using magnetic resonance images (MRI). Convolutional Neural Networks (CNN) are one of th…

Fluorescence Emission Wavelength QSPR Application with Linear Blending Method in Machine Learning Algorithms Open

Nina Bryan, Dewayne A Dixon, Seonguk Kim, Yeona Kang · 2022

Machine learning tools have been developed to analyze quantitative structure-activity/property relationship (QSAR/QSPR) modeling research. Better feature selection algorithms in the ensemble methods have been used to advance QSPR/QSAR mode…

Naloxone’s dose-dependent displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain Open

Yeona Kang, Kelly A. O’Conor, Andrew Kelleher, J Tyler Ramsey, Abolghasem Bakhoda , et al. · 2022

Naloxone’s displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain: implications for opioid overdose reversal Open

Yeona Kang, Kelly A. O’Conor, Andrew Kelleher, J Tyler Ramsey, Gus Bakhoda , et al. · 2022

The continuous rise in opioid overdoses in the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (NLX) has been shown to effectively reverse overdoses…

A Baboon Brain Atlas for Magnetic Resonance Imaging and Positron Emission Tomography Image Analysis Open

Artur Agaronyan, Raeyan Syed, Ryan Kim, Chao‐Hsiung Hsu, Scott Love , et al. · 2022

The olive baboon ( Papio anubis ) is phylogenetically proximal to humans. Investigation into the baboon brain has shed light on the function and organization of the human brain, as well as on the mechanistic insights of neurological disord…

Discovery of Highly Potent Adenosine A1 Receptor Agonists: Targeting Positron Emission Tomography Probes Open

Min Guo, Abolghasem Bakhoda, Zhan‐Guo Gao, Joseph M. Ramsey, Yang Li , et al. · 2021

Adenosine receptor (AR) radiotracers for positron emission tomography (PET) have provided knowledge on the in vivo biodistribution of ARs in the central nervous system (CNS), which is of therapeutic interest for various neuropsychia…

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis Open

Yeona Kang, Sneha Pandya, Nicole Zinger, Nara Miriam Michaelson, Susan A. Gauthier · 2021

The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. …

Feasibility of a three-dimensional rotational angiography road map for individualized guidance of uterine artery catheterization Open

Weiqin Li, Xiaofeng Deng, Guobin Li, Yeona Kang · 2020

Objectives: This study aimed to compare the feasibility and advantages of a three-dimensional rotational angiography (3DRA) road map for individualized guidance of uterine artery (UA) catheterization with those of a conventional two-dimens…

A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis Open

Yeona Kang, Sandra Hurtado Rúa, Ulrike W. Kaunzner, Jai Perumal, Nancy Nealon , et al. · 2020

Neurophysiological Biomarkers of Parkinson’s Disease Open

Shani Waninger, Chris Berka, Marija Stevanović Karić, Stephanie Korszen, P. David Mozley , et al. · 2020

Our results support the utility of EEG in characterizing alterations in neurophysiological oscillatory activity associated with Parkinson's disease and highlight potential as a reliable method for monitoring disease progression and as a ph…

PET is necessary to make the next step forward in understanding MS pathophysiology – Commentary Open

Yeona Kang, Susan A. Gauthier · 2019

Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions Open

Ulrike W. Kaunzner, Yeona Kang, Shun Zhang, Eric Morris, Yihao Yao , et al. · 2018

Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched, activated microglia and macrophages, have been linked to greater tissue damage. Post-mortem studies have determined that chronic active lesion…

18F‐FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease Open

Yeona Kang, Claire Henchcliffe, Ajay Verma, Shankar Vallabhajosula, Bin He , et al. · 2018

BACKGROUND AND PURPOSE Dopamine and glutamate reciprocally regulate each other in some of the neurocircuits affected by Parkinson's disease (PD). The objective of this pilot study was to explore relationships between these neurotransmitter…

Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11]PK11195 Open

Yeona Kang, David J. Schlyer, Ulrike W. Kaunzner, Amy Kuceyeski, Paresh J. Kothari , et al. · 2018

Chronic active multiple sclerosis (MS) lesions have a rim of activated microglia/macrophages (m/M) leading to ongoing tissue damage, and thus represent a potential treatment target. Activation of this innate immune response in MS has been …

Noninvasive PK11195‐PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease Open

Yeona Kang, P. David Mozley, Ajay Verma, David J. Schlyer, Claire Henchcliffe , et al. · 2018

BACKGROUND AND PURPOSE Neuroinflammation has been implicated in the pathophysiology of Parkinson's disease (PD), which might be influenced by successful neuroprotective drugs. The uptake of [ 11 C](R)‐PK11195 (PK) is often considered to be…

[11C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use Open

Francesca Zanderigo, Yeona Kang, Dileep Kumar, Anastasia Nikolopoulou, P. David Mozley , et al. · 2017

Arachidonic acid (AA) is involved in signal transduction, neuroinflammation, and production of eicosanoid metabolites. The AA brain incorporation coefficient (K*) is quantifiable in vivo using [ 11 C]AA positron emission tomography, althou…

Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation Open

Ulrike W. Kaunzner, Yeona Kang, Elizabeth Monohan, Paresh J. Kothari, Nancy Nealon , et al. · 2017

Transient and chronic seizure‐induced inflammation in human focal epilepsy Open

Tracy Butler, Yi Li, Wai Tsui, Daniel Friedman, Anat Maoz , et al. · 2016

Summary In animal models, inflammation is both a cause and consequence of seizures. Less is known about the role of inflammation in human epilepsy. We performed positron emission tomography ( PET ) using a radiotracer sensitive to brain in…

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