Yepin Yu
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View article: Host Specificity and Geographic Dispersion Shape Virome Diversity in <i>Rhinolophus</i> Bats
Host Specificity and Geographic Dispersion Shape Virome Diversity in <i>Rhinolophus</i> Bats Open
Rhinolophus bats have been identified as natural reservoirs for viruses with global health implications, including severe acute respiratory syndrome–related coronaviruses (SARSr‐CoV) and swine acute diarrhoea syndrome‐related coronavirus (…
View article: Fish <i>Snx27</i> promotes viral products by modulating the innate immune response and exosomal machinery
Fish <i>Snx27</i> promotes viral products by modulating the innate immune response and exosomal machinery Open
Viral nervous necrosis caused by the nervous necrosis virus (NNV) poses a significant threat to the global aquaculture industry. Developing preventive methods to minimize economic losses due to NNV infections is crucial. This study explore…
View article: Proteomics and Microbiota Conjoint Analysis in the Nasal Mucus: Revelation of Differences in Immunological Function in Manis javanica and Manis pentadactyla
Proteomics and Microbiota Conjoint Analysis in the Nasal Mucus: Revelation of Differences in Immunological Function in Manis javanica and Manis pentadactyla Open
All eight pangolin species, especially captive Manis pentadactyla, are critically endangered and susceptible to various pathogenic microorganisms, causing mass mortality. They are involved in the complement system, iron transport system, a…
View article: Host specificity and geographic dispersion shape virome diversity in Rhinolophus bats
Host specificity and geographic dispersion shape virome diversity in Rhinolophus bats Open
Background Many zoonotic viruses originated from bats. Notably, Rhinolophus bats have been identified as natural reservoirs for some viruses with global health implications, including severe acute respiratory syndrome–related coronaviruses…
View article: A novel cell communication method reveals that grik4 and gabrd may be critical for inducing death in RGNNV-infected groupers
A novel cell communication method reveals that grik4 and gabrd may be critical for inducing death in RGNNV-infected groupers Open
To investigate the infectious mechanism of RGNNV, we adopted multi-omics methods to study the precise cellular interactions. We combined proteomic, bulk-RNA seq and sc-RNA seq to search for the secret of RGNNV’s influence on the nervous sy…
View article: Detection of a novel Pestivirus strain in Java ticks (Amblyomma javanense) and the hosts Malayan pangolin (Manis javanica) and Chinese pangolin (Manis pentadactyla)
Detection of a novel Pestivirus strain in Java ticks (Amblyomma javanense) and the hosts Malayan pangolin (Manis javanica) and Chinese pangolin (Manis pentadactyla) Open
Pangolins are endangered animals and are listed in the CITES Appendix I of the Convention International Trade Endangered Species of Wild Fauna and Flora as well as being the national first-level protected wild animal in China. Based on a f…
View article: Epidemiology and Genomic Characterization of Two Novel SARS-Related Coronaviruses in Horseshoe Bats from Guangdong, China
Epidemiology and Genomic Characterization of Two Novel SARS-Related Coronaviruses in Horseshoe Bats from Guangdong, China Open
Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 probably originated from the SARS-related coronaviruses (SARSr-CoVs) carried by Rhinolophus bats from Yunnan, China. Systematic investigations of the reservoir hosts c…
View article: LAMP for the rapid diagnosis of iridovirus in aquaculture
LAMP for the rapid diagnosis of iridovirus in aquaculture Open
Iridoviruses are DNA virus and have caused huge economic losses in the aquaculture industry. The aim of this study was to establish a colorimetric loop-mediated isothermal amplification (LAMP) protocol for the on-site detection of Singapor…
View article: Efficient RNA Virus Targeting via CRISPR/CasRx in Fish
Efficient RNA Virus Targeting via CRISPR/CasRx in Fish Open
RNA viruses are important viral pathogens infecting vertebrates and mammals. RNA virus populations are highly dynamic due to short generation times, large population sizes, and high mutation frequencies.
View article: Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway
Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway Open
Palmitic acid is the most common saturated fatty acid in animals, plants, and microorganisms. Studies highlighted that palmitic acid plays a significant role in diverse cellular processes and viral infections. Accumulation of palmitic acid…
View article: Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication
Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication Open
Autophagy is a conserved catabolic process that occurs at basal levels to maintain cellular homeostasis. Most virus infections can alter the autophagy level, which functions as either a pro-viral or antiviral pathway, depending on the viru…
View article: Development of a Novel Lateral Flow Biosensor Combined With Aptamer-Based Isolation: Application for Rapid Detection of Grouper Nervous Necrosis Virus
Development of a Novel Lateral Flow Biosensor Combined With Aptamer-Based Isolation: Application for Rapid Detection of Grouper Nervous Necrosis Virus Open
Nervous necrosis virus (NNV) has infected more than 50 fish species worldwide, and has caused serious economic losses in the aquaculture industries. However, there is no effective antiviral therapy. The development of a rapid and accurate …
View article: The roles of grouper clathrin light chains in regulating the infection of a novel marine DNA virus, Singapore grouper iridovirus
The roles of grouper clathrin light chains in regulating the infection of a novel marine DNA virus, Singapore grouper iridovirus Open
Clathrins, composed of clathrin heavy chains (CHCs) and clathrin light chains (CLCs), are usually hijacked by viruses for infection. However, the role of CLCs, especially in regulating fish virus infection, remains poorly understood. Here,…
View article: First report of bovine herpesvirus 1 isolation from bull semen samples in China
First report of bovine herpesvirus 1 isolation from bull semen samples in China Open
Bovine herpesvirus 1 (BoHV-1) infection causes substantial economic losses to the cattle industry worldwide. So far, the isolation of BoHV-1 field virus has not been reported in China. Here, for the first time we report that two isolates o…
View article: Negative regulation of the innate antiviral immune response by TRIM62 from orange spotted grouper
Negative regulation of the innate antiviral immune response by TRIM62 from orange spotted grouper Open
Increased reports uncovered that mammalian tripartite motif-containing 62 (TRIM62) exerts crucial roles in cancer and innate immune response. However, the roles of fish TRIM62 in antiviral immune response remained uncertain. In this study,…