Yeqi Li
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View article: Tailoring mRNA lipid nanoparticles for antifungal vaccines
Tailoring mRNA lipid nanoparticles for antifungal vaccines Open
Vaccination is one of the most effective public health measures for preventing and managing infectious diseases. Despite intensive efforts from the relatively small medical mycology community, developing effective vaccines against invasive…
View article: Anionic lipids direct efficient microfluidic encapsulation of stable and functionally active proteins in lipid nanoparticles
Anionic lipids direct efficient microfluidic encapsulation of stable and functionally active proteins in lipid nanoparticles Open
Because proteins do not efficiently pass through the plasma membrane, protein therapeutics are limited to target ligands located at the cell surface or in serum. Lipid nanoparticles can facilitate delivery of polar molecules across a membr…
View article: Identification of a protective antigen reveals the trade-off between iron acquisition and antigen exposure in a global fungal pathogen
Identification of a protective antigen reveals the trade-off between iron acquisition and antigen exposure in a global fungal pathogen Open
Systemic infections caused by Cryptococcus claim over 161,000 lives annually, with global mortality rate close to 70% despite antifungal therapies. Currently, no vaccine is available. To develop an effective multivalent vaccine against thi…
View article: The synergistic effect of extracellular polysaccharide-producing salt-tolerant bacteria and biochar promotes grape growth under saline-alkaline stress
The synergistic effect of extracellular polysaccharide-producing salt-tolerant bacteria and biochar promotes grape growth under saline-alkaline stress Open
View article: Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model
Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model Open
Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles…
View article: Aspartyl peptidase May1 induces host inflammatory response by altering cell wall composition in the fungal pathogen <i>Cryptococcus neoformans</i>
Aspartyl peptidase May1 induces host inflammatory response by altering cell wall composition in the fungal pathogen <i>Cryptococcus neoformans</i> Open
Cryptococcus neoformans causes cryptococcal meningoencephalitis, a disease that kills more than 180,000 people annually. Contributing to its success as a fungal pathogen is its cell wall surrounded by a capsule. When the cryptococcal cell …
View article: Brain glucose induces fungicidal tolerance during fungal meningitis
Brain glucose induces fungicidal tolerance during fungal meningitis Open
In bacteria, antibiotic tolerance, the ability of a susceptible population to survive high doses of cidal drugs, has been shown to compromise therapeutic outcomes. In comparison, whether fungicide tolerance can be induced by host-derived f…
View article: Vaccination with a <i>ZNF2</i> <sup>oe</sup> Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts
Vaccination with a <i>ZNF2</i> <sup>oe</sup> Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts Open
Systemic cryptococcosis is fatal without treatment. Even with the current antifungal therapies, this disease kills 180,000 of 225,000 infected people annually.
View article: The C <sub>2</sub> H <sub>2</sub> -Type Transcription Factor ZfpA, Coordinately with CrzA, Affects Azole Susceptibility by Regulating the Multidrug Transporter Gene <i>atrF</i> in Aspergillus fumigatus
The C <sub>2</sub> H <sub>2</sub> -Type Transcription Factor ZfpA, Coordinately with CrzA, Affects Azole Susceptibility by Regulating the Multidrug Transporter Gene <i>atrF</i> in Aspergillus fumigatus Open
Conserved across all kingdoms of life, ABC transporters comprise one of the largest protein families. They are associated with multidrug resistance, affecting aspects such as resistance to antimicrobials or anticancer drugs.
View article: Slope position- mediated soil environmental filtering drives plant community assembly processes in hilly shrublands of Guilin, China
Slope position- mediated soil environmental filtering drives plant community assembly processes in hilly shrublands of Guilin, China Open
Background and aims A major goal of community ecology focuses on trying to understand how environmental filter on plant functional traits drive plant community assembly. However, slopes positions- mediated soil environmental factors on com…
View article: Identification and Characterization of an Intergenic “Safe Haven” Region in Human Fungal Pathogen Cryptococcus gattii
Identification and Characterization of an Intergenic “Safe Haven” Region in Human Fungal Pathogen Cryptococcus gattii Open
Cryptococcus gattii is a primary fungal pathogen, which causes pulmonary and brain infections in healthy as well as immunocompromised individuals. Genetic manipulations in this pathogen are widely employed to study its biology and pathogen…
View article: Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance
Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance Open
Drug resistance in fungal pathogens has risen steadily over the past decades due to long-term azole therapy or triazole usage in agriculture. Modification of the drug target protein to prevent drug binding is a major recognized route to in…
View article: Screening and Characterization of a Non- <i>cyp51A</i> Mutation in an <i>Aspergillus fumigatus cox10</i> Strain Conferring Azole Resistance
Screening and Characterization of a Non- <i>cyp51A</i> Mutation in an <i>Aspergillus fumigatus cox10</i> Strain Conferring Azole Resistance Open
The rapid and global emergence of azole resistance in the human pathogen Aspergillus fumigatus has drawn attention. Thus, a thorough understanding of its mechanisms of drug resistance requires extensive exploration. In this study, we found…