Yeran Li
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View article: A retrospective study to assess real-world treatment patterns and outcomes in luspatercept-treated patients with myelofibrosis-associated anemia who required red blood cell transfusion in the United States
A retrospective study to assess real-world treatment patterns and outcomes in luspatercept-treated patients with myelofibrosis-associated anemia who required red blood cell transfusion in the United States Open
Introduction Most patients with myelofibrosis (MF) will develop anemia, contributing to poor quality of life and reduced survival. In the phase 2 ACE-536-MF-001 study (NCT03194542), luspatercept, a first-in-class erythroid maturation agent…
View article: Clinical Burden of Recurrent Disease in High-Risk Endometrial Cancer
Clinical Burden of Recurrent Disease in High-Risk Endometrial Cancer Open
The findings of this study suggest that DFS may be a useful surrogate for OS in high-risk endometrial cancer, though validation in trial-level meta-analyses is needed, and highlight the substantial burden associated with recurrent disease,…
View article: Creating Perforations in the Sclerotic Region of the Proximal Tibia During Total Knee Arthroplasty to Enhance Prosthesis Stability
Creating Perforations in the Sclerotic Region of the Proximal Tibia During Total Knee Arthroplasty to Enhance Prosthesis Stability Open
Objective In patients with varus deformity of the knee, the redistribution of the subchondral bone mineral density (BMD) of the tibia leads to sclerotic zones that may cause osteoarthritis. Drilling the sclerotic area of the tibia prior to…
View article: Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population [Corrigendum]
Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population [Corrigendum] Open
[This corrects the article DOI: 10.2147/DMSO.S249025.].
View article: Using AI and Social Media to Understand Health Disparities for Transgender Cancer Care
Using AI and Social Media to Understand Health Disparities for Transgender Cancer Care Open
This qualitative study used an artificial intelligence (AI) large language model and social media to investigate challenges encountered by transgender individuals during breast and gynecological cancer care.
View article: Use of Deep Learning for Full-text Data Elements Extraction for Systematic Literature Review Tasks
Use of Deep Learning for Full-text Data Elements Extraction for Systematic Literature Review Tasks Open
Background: Systematic literature review (SLR) is an important tool for Health Economics and Outcomes Research (HEOR) evidence synthesis. SLRs involve the identification and selection of pertinent publications and extraction of relevant da…
View article: #821 A data-driven disease burden model based on molecular classification in endometrial cancer patients in five european countries
#821 A data-driven disease burden model based on molecular classification in endometrial cancer patients in five european countries Open
Introduction/Background Endometrial carcinoma (EC) is the most common gynaecological cancer in Europe and has an increasing incidence. The latest treatment guideline has integrated molecular profile into risk stratification, and emerging t…
View article: Corrigendum to “Adjuvant and first line chemotherapy use for endometrial cancer” [Gynecol. Oncol. Rep. 41 (2022) 101002]
Corrigendum to “Adjuvant and first line chemotherapy use for endometrial cancer” [Gynecol. Oncol. Rep. 41 (2022) 101002] Open
[This corrects the article DOI: 10.1016/j.gore.2022.101002.].
View article: Pembrolizumab-combination therapy for previously untreated metastatic nonsquamous NSCLC: Real-world outcomes at US oncology practices
Pembrolizumab-combination therapy for previously untreated metastatic nonsquamous NSCLC: Real-world outcomes at US oncology practices Open
Objectives The availability of immunotherapies has expanded the options for treating metastatic NSCLC, but information is needed regarding outcomes of immunotherapy for patients treated outside of clinical trials. The aim of this retrospec…
View article: Adjuvant and first line chemotherapy use for endometrial cancer
Adjuvant and first line chemotherapy use for endometrial cancer Open
Among patients with endometrial cancer who underwent hysterectomy, platinum-taxane combination chemotherapy was used in almost 90% of patients who received adjuvant chemotherapy while nearly 70% of patients who recurred were treated with p…
View article: Real-World Time on Treatment with First-Line Pembrolizumab Monotherapy for Advanced NSCLC with PD-L1 Expression ≥ 50%: 3-Year Follow-Up Data
Real-World Time on Treatment with First-Line Pembrolizumab Monotherapy for Advanced NSCLC with PD-L1 Expression ≥ 50%: 3-Year Follow-Up Data Open
Our aim was to evaluate real-world time on treatment (rwToT), overall and by KRAS mutation status, with first-line pembrolizumab monotherapy for advanced non-small cell lung cancer (NSCLC) in real-world oncology practice in the US. rwToT i…
View article: <p>Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population</p>
Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population Open
METS-IR in female KOA was higher than that of the national baseline. The METS-IR was related to adipokine disorder and inflammatory activity. These findings suggest that METS-IR can be used to evaluate the degree of involvement of MetS in …
View article: Finite element analysis of the effect of tibial prosthesis extension stem length in total knee arthroplasty in the Chinese population
Finite element analysis of the effect of tibial prosthesis extension stem length in total knee arthroplasty in the Chinese population Open
Background This study aimed to determine the longest usable range of tibial prosthesis extension stems in Chinese patients undergoing primary total knee arthroplasty and to analyze the effect of different stem lengths on prosthesis stabili…
View article: Analysis of the effect of tibial torsion on tibial osteotomy in knee arthroplasty using a three-dimensional computed tomography-based modelling technique
Analysis of the effect of tibial torsion on tibial osteotomy in knee arthroplasty using a three-dimensional computed tomography-based modelling technique Open
Prospectively registered.
View article: JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in <i>Drosophila</i>
JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in <i>Drosophila</i> Open
In flies, the chromosomal kinase JIL-1 is responsible for most interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from acquiring heterochromatic marks, like dimethylated histone H3K9 (H3K9me2) and HP…
View article: Electrodes: Improving Supercapacitance of Electrospun Carbon Nanofibers through Increasing Micropores and Microporous Surface Area (Adv. Mater. Interfaces 6/2019)
Electrodes: Improving Supercapacitance of Electrospun Carbon Nanofibers through Increasing Micropores and Microporous Surface Area (Adv. Mater. Interfaces 6/2019) Open
In article number 1801900 by He Wang, Wenyu Wang, Tong Lin, and co-workers, carbon nanofibers were prepared from co-electrospun polyacrylonitrile with a second polymer. The group shows that the second polymer with high melting point and lo…
View article: Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation
Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation Open
In Drosophila it has recently been demonstrated that a spindle matrix in the form of a membrane-less macromolecular assembly embeds the microtubule-based spindle apparatus. In addition, two of its constituents, Megator and Chromator, were …
View article: Comparing deep learning and concept extraction based methods for patient phenotyping from clinical narratives
Comparing deep learning and concept extraction based methods for patient phenotyping from clinical narratives Open
In secondary analysis of electronic health records, a crucial task consists in correctly identifying the patient cohort under investigation. In many cases, the most valuable and relevant information for an accurate classification of medica…
View article: H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation
H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation Open
A model has been proposed in which JIL-1 kinase-mediated H3S10 and H2Av phosphorylation is required for transcriptional elongation and heat shock-induced chromatin decondensation. However, here we show that although H3S10 phosphorylation i…