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View article: Multiplexed Pan Soluble Ligandome Assaying via OASIS
Multiplexed Pan Soluble Ligandome Assaying via OASIS Open
Screening soluble protein ligands is essential for understanding signaling interactions and enabling drug discovery. Currently, screens require arrayed formats because ligand diffusibility causes non-cell-autonomous effects. To enable mult…
View article: Regulatable In Vivo Gene Expression via Adaptamers
Regulatable In Vivo Gene Expression via Adaptamers Open
Precise, reversible control of transgene expression is essential for safe and durable gene therapy, yet current inducible systems remain difficult to translate in vivo due to large size, limited induction duration, and dependence on immuno…
View article: Biosecurity Primitive: Polymerase X‐based Genetic Physical Unclonable Functions
Biosecurity Primitive: Polymerase X‐based Genetic Physical Unclonable Functions Open
A Physical Unclonable Function (PUF) is a security primitive that exploits inherent variations in manufacturing protocols to generate unique, random‐like identifiers. These identifiers are used for authentication and encryption purposes in…
View article: A Perturbation Cell Atlas of Human Induced Pluripotent Stem Cells
A Perturbation Cell Atlas of Human Induced Pluripotent Stem Cells Open
SUMMARY Towards comprehensively investigating the genotype-phenotype relationships governing the human pluripotent stem cell state, we generated an expressed genome-scale CRISPRi Perturbation Cell Atlas in KOLF2.1J human induced pluripoten…
View article: Cell Maps for Artificial Intelligence: AI-Ready Maps of Human Cell Architecture from Disease-Relevant Cell Lines
Cell Maps for Artificial Intelligence: AI-Ready Maps of Human Cell Architecture from Disease-Relevant Cell Lines Open
This article describes the Cell Maps for Artificial Intelligence (CM4AI) project and its goals, methods, standards, current datasets, software tools, status, and future directions. CM4AI is the Functional Genomics Data Generation Project i…