Yevgen Levdansky
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View article: mRNA poly(A)-tail length is a battleground for coronavirus–host competition
mRNA poly(A)-tail length is a battleground for coronavirus–host competition Open
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we report that coronavirus infection causes …
View article: A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function Open
RNA-binding proteins (RBPs) are key regulators of gene expression; however, their RNA-binding specificities, that is, motifs, have not been comprehensively determined. Here we introduce Eukaryotic Protein–RNA Interactions (EuPRI), a freely…
View article: Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay Open
Legionella pneumophila , an intracellular bacterial pathogen, injects effector proteins into host cells to manipulate cellular processes and promote its survival and proliferation. Here, we reveal a unique mechanism by which the Legionella…
View article: Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay
Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay Open
Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants containing mor…
View article: Structure and assembly of the NOT10:11 module of the CCR4-NOT complex
Structure and assembly of the NOT10:11 module of the CCR4-NOT complex Open
NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT remains poorly understood. Here, we presen…
View article: Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome
Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome Open
Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are essential for vertebrate development and neurological functions. PUM1&2 negatively regulate gene expression by accelerating degradation of specific mRNAs.…
View article: Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome
Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome Open
Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are essential for vertebrate development and neurological functions. PUM1&2 negatively regulate gene expression by accelerating degradation of specific mRNAs.…
View article: Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs
Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs Open
Pumilio is an RNA-binding protein that represses a network of mRNAs to control embryogenesis, stem cell fate, fertility and neurological functions in Drosophila. We sought to identify the mechanism of Pumilio-mediated repression and find t…
View article: Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs
Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs Open
Pumilio is an RNA-binding protein that represses a network of mRNAs to control embryogenesis, stem cell fate, fertility, and neurological functions in Drosophila . We sought to identify the mechanism of Pumilio-mediated repression and find…
View article: A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay
A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay Open
XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated and decapped mRNAs in the last step of the 5′–3′ mRNA decay pathway. Metazoan XRN1 interacts with decapping factors coupling the final stages of decay…
View article: Virion Structure of Iflavirus Slow Bee Paralysis Virus at 2.6-Angstrom Resolution
Virion Structure of Iflavirus Slow Bee Paralysis Virus at 2.6-Angstrom Resolution Open
The western honeybee ( Apis mellifera ) is the most important commercial insect pollinator. However, bees are under pressure from habitat loss, environmental stress, and pathogens, including viruses that can cause lethal epidemics. Slow be…