Yi‐Chun Tsai
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View article: An image-guided high-precision research platform for ultra-high dose rate spinal cord toxicity studies
An image-guided high-precision research platform for ultra-high dose rate spinal cord toxicity studies Open
Objective: While FLASH radiotherapy is recognized for short-term normal tissue sparing, its durability in late-responding organs remains uncertain, limiting clinical adoption. With its clinical importance and steep dose-response, the spina…
View article: Circulating short-chain fatty acids and subclinical cardiovascular disease in type 2 diabetes mellitus
Circulating short-chain fatty acids and subclinical cardiovascular disease in type 2 diabetes mellitus Open
Our study demonstrates that serum SCFAs are potential biomarkers of the early stage of cardiovascular remodeling in patients with T2D.
View article: A Design Science Study of a Mobile Human Resource System for Internal Staffing and User Acceptance
A Design Science Study of a Mobile Human Resource System for Internal Staffing and User Acceptance Open
This study addresses the limited research on IT-enabled support for internal staffing by employing a design science research (DSR) methodology to design, develop, and evaluate a mobile-based staffing and task assignment management system (…
View article: Comprehensive characterization and validation of a fast‐resolving (1000 Hz) plastic scintillator for ultra‐high dose rate electron dosimetry
Comprehensive characterization and validation of a fast‐resolving (1000 Hz) plastic scintillator for ultra‐high dose rate electron dosimetry Open
Background The normal tissue sparing effect of ultra‐high dose rate irradiation (≥40 Gy/s, UHDR), as compared to conventional dose rate (CONV), has attracted significant research interest for FLASH radiotherapy (RT). Accurate, dose rate in…
View article: Assessing FLASH Effect on Late-Responding Organ Toxicity in Hypofractionation Using a Rat Spinal Cord Model
Assessing FLASH Effect on Late-Responding Organ Toxicity in Hypofractionation Using a Rat Spinal Cord Model Open
View article: Sodium–glucose cotransporter 2 inhibitors ameliorate glutathione cysteine ligase modifier-mediated oxidative stress and subsequent ferroptosis in proximal tubules of diabetic kidney disease
Sodium–glucose cotransporter 2 inhibitors ameliorate glutathione cysteine ligase modifier-mediated oxidative stress and subsequent ferroptosis in proximal tubules of diabetic kidney disease Open
SGLT2i reduced ferroptosis in PT by boosting GCLM expression, thereby slowing DKD progression, revealing that GCLM has the potential against DKD.
View article: New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets
New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets Open
The aryl hydrocarbon receptor (AHR) plays crucial roles in the control of stress, xenobiotic metabolism, inflammation, and cancer. However, information on the chromatin regulation of ligand-dependent AHR promoter activation is limit…
View article: Interplay between Skin Sympathetic Nerve Activity and Gut Microbiota, the Neurocardiac Axis in Acute Coronary Syndrome
Interplay between Skin Sympathetic Nerve Activity and Gut Microbiota, the Neurocardiac Axis in Acute Coronary Syndrome Open
BACKGROUND Previous studies have linked gut dysbiosis to the acute coronary syndrome (ACS) and sympathetic nervous system disturbances. However, the relationship between skin sympathetic nerve activity (SKNA) and gut microbiota in ACS pati…
View article: Circulating short chain fatty acid levels and body composition in type 2 diabetes mellitus
Circulating short chain fatty acid levels and body composition in type 2 diabetes mellitus Open
Background: Short-chain fatty acids (SCFAs) may play key functional roles in the pathophysiology of type 2 diabetes (T2D) through regulating energy intake and substrate metabolism. Body composition, including fat tissue, muscle tiss…
View article: Biomarkers in Contrast-Induced Nephropathy: Advances in Early Detection, Risk Assessment, and Prevention Strategies
Biomarkers in Contrast-Induced Nephropathy: Advances in Early Detection, Risk Assessment, and Prevention Strategies Open
Contrast-induced nephropathy (CIN) represents a significant complication associated with the use of iodinated contrast media (ICM), especially in individuals with preexisting renal impairment. The pathophysiology of CIN encompasses oxidati…
View article: Comprehensive investigation of HYPERSCINT RP-FLASH scintillator for electron FLASH research
Comprehensive investigation of HYPERSCINT RP-FLASH scintillator for electron FLASH research Open
Accurate, dose-rate-independent, fast-response dosimeters that capture the spatiotemporal characteristics of ultra-high dose rate irradiation (>40Gy/s, UHDR) beams are urgently needed to facilitate FLASH research and support the clinical t…
View article: The Impact of Mobile Health on Blood Pressure and Health Literacy in Chronic Kidney Disease: Randomized Open-Label Clinical Trial (Preprint)
The Impact of Mobile Health on Blood Pressure and Health Literacy in Chronic Kidney Disease: Randomized Open-Label Clinical Trial (Preprint) Open
BACKGROUND Mobile health (mHealth) management is an emerging therapeutic strategy for chronic diseases. Although it has been shown to improve self-care management and assist in the early detection of a worsening health status. Its effect …
View article: The Impact of Mobile Health on Blood Pressure and Health Literacy in Chronic Kidney Disease: Randomized Open-Label Clinical Trial (Preprint)
The Impact of Mobile Health on Blood Pressure and Health Literacy in Chronic Kidney Disease: Randomized Open-Label Clinical Trial (Preprint) Open
View article: Phthalate exposure increases oxidative stress, early renal injury, and the risk of calcium urolithiasis: A case-control study
Phthalate exposure increases oxidative stress, early renal injury, and the risk of calcium urolithiasis: A case-control study Open
Our study uncovers a novel association between phthalate exposure and the risk of urolithiasis, underscoring the heightened risk of kidney injury posed by such exposure. Considering the widespread presence of phthalates, regulatory measure…
View article: Blood osteoprotegerin is associated with arteriovenous access thrombosis in hemodialysis patients
Blood osteoprotegerin is associated with arteriovenous access thrombosis in hemodialysis patients Open
High blood OPG was associated with AV access thrombosis, particularly in the AVF.
View article: Benchmark Dose of Melamine Exposure for a Renal Injury Marker Mediated by Oxidative Stress: Examples in Patients with Urolithiasis and Occupational Workers
Benchmark Dose of Melamine Exposure for a Renal Injury Marker Mediated by Oxidative Stress: Examples in Patients with Urolithiasis and Occupational Workers Open
Establishing a safe exposure level from epidemiological studies while providing direct hazard characterization in humans often faces uncertainty in causality, especially cross-sectional data. With advances in molecular epidemiology, it is …
View article: Development of a Predictive Nomogram for Sepsis in Patients with Urolithiasis-Related Obstructive Pyelonephritis
Development of a Predictive Nomogram for Sepsis in Patients with Urolithiasis-Related Obstructive Pyelonephritis Open
Background and Objectives: In patients with urolithiasis-related obstructive pyelonephritis (UROP), sepsis represents a critical and concerning complication that can substantially increase the mortality rate. This study aimed to identify t…
View article: Sex differences in the association of long-term exposure to heat stress on kidney function in a large Taiwanese population study
Sex differences in the association of long-term exposure to heat stress on kidney function in a large Taiwanese population study Open
View article: Association between wet-bulb globe temperature and kidney function in different geographic regions in a large Taiwanese population study
Association between wet-bulb globe temperature and kidney function in different geographic regions in a large Taiwanese population study Open
The worldwide prevalence and incidence rates of end-stage renal disease have been increasing, and the trend is pronounced in Taiwan. This is especially evident in southern Taiwan, where the wet-bulb globe temperature (WBGT) is consistently…
View article: Development of a predictive nomogram for sepsis in patients with urolithiasis-related obstructive pyelonephritis
Development of a predictive nomogram for sepsis in patients with urolithiasis-related obstructive pyelonephritis Open
Background: In patients with urolithiasis-related obstructive pyelonephritis (UROP), sepsis represents a critical and concerning complication that can substantially increase the mortality rate. This study aimed to identify the risk factors…
View article: Diagnostic accuracy of procalcitonin in adult non-neutropenic cancer patients with suspected infection: a systematic review and meta-analysis
Diagnostic accuracy of procalcitonin in adult non-neutropenic cancer patients with suspected infection: a systematic review and meta-analysis Open
View article: Association Between Trimethylamine N-oxide and Adverse Kidney Outcomes and Overall Mortality in Type 2 Diabetes Mellitus
Association Between Trimethylamine N-oxide and Adverse Kidney Outcomes and Overall Mortality in Type 2 Diabetes Mellitus Open
Context Type 2 diabetes (T2D) is the major contributor to chronic kidney disease and end-stage kidney disease (ESKD). The influence of trimethylamine N-oxide (TMAO) on kidney outcomes in T2D remains unclear. Objective To examine the associ…
View article: The factors of perceived disease knowledge and self-care behavior in type 2 diabetic patients with chronic kidney disease: A cross-sectional study
The factors of perceived disease knowledge and self-care behavior in type 2 diabetic patients with chronic kidney disease: A cross-sectional study Open
Chronic kidney diseases (CKD) is an important public health issue worldwide, and diabetes mellitus is the main cause of CKD. Having sufficient disease knowledge and good self-care behavior both help to prevent the progression of diabetes m…
View article: Who needs to be screened for primary aldosteronism?
Who needs to be screened for primary aldosteronism? Open
The prevalence of patients with primary aldosteronism (PA) is about 5%-15% in hypertensive patients, and it is common cause of secondary hypertension in clinical practice. Two major causes of PA are noted, namely bilateral adrenal hyperpla…
View article: Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease
Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease Open
View article: Sex-specific interactive effect of melamine and DEHP on a marker of early kidney damage in Taiwanese adults: A national population-based study from the Taiwan Biobank
Sex-specific interactive effect of melamine and DEHP on a marker of early kidney damage in Taiwanese adults: A national population-based study from the Taiwan Biobank Open
Taiwan had the high incidence of chronic kidney disease (CKD) worldwide. Our objective was to examine associations between daily exposure of phthalates and melamine, two common nephrotoxins, and kidney damage risk in a well-established nat…
View article: #4102 THE IMPACT OF MOBILE HEALTH ON HOME BLOOD PRESSURE AND HEALTH LITERACY IN CHRONIC KIDNEY DISEASE
#4102 THE IMPACT OF MOBILE HEALTH ON HOME BLOOD PRESSURE AND HEALTH LITERACY IN CHRONIC KIDNEY DISEASE Open
Background and Aims Mobile health (mHealth) management is an emerging therapeutic strategy for chronic diseases. mHealth has been considered to improve self-care management and assist in detecting a worsening health status early. However, …
View article: #3383 ASSOCIATION BETWEEN MELAMINE AND PHTHALATES AND URINARY RENAL INJURY MARKERS AMONG CHILDREN AGED 4 YEARS
#3383 ASSOCIATION BETWEEN MELAMINE AND PHTHALATES AND URINARY RENAL INJURY MARKERS AMONG CHILDREN AGED 4 YEARS Open
Background and Aims Chronic kidney disease (CKD) is a global public health issue and the prevalence and incidence of CKD and end-stage renal disease (ESRD) in Taiwan are among the highest in the world. The pathophysiology of renal function…
View article: #3447 ENVIRONMENTAL MELAMINE EXPOSURE AND ADVERSE KIDNEY OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
#3447 ENVIRONMENTAL MELAMINE EXPOSURE AND ADVERSE KIDNEY OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Open
Background and Aims The impact of environmental melamine exposure on kidney outcomes in type 2 diabetes (T2D) remains unclear. The aim of this study is to evaluate the relationship between melamine and adverse kidney progression in T2D pop…
View article: Effect of extended field‐of‐view approaches on the accuracy of stopping power ratio estimation for single‐energy computed tomography simulators
Effect of extended field‐of‐view approaches on the accuracy of stopping power ratio estimation for single‐energy computed tomography simulators Open
Background Extended field‐of‐view (eFOV) methods have been proposed to generate larger demonstration FOVs for computed tomography (CT) simulators with a limited scanning FOV (sFOV) size in order to ensure accurate dose calculation and pati…