Yi-Hsun Ho
YOU?
Author Swipe
View article: Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis
Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis is incurable, and its progression is difficult to control and thus can lead to pulmonary deterioration. Pan-histone deacetylase inhibitors such as SAHA have shown potential for modulating pulmonary fibrosis ye…
View article: Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD
Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD Open
Acetylation at the α-N-terminus (Nα) is the most abundant modification detected on histone H4 and H2A, which is catalyzed by N-terminal acetyltransferase D (NatD or NAA40). Histone H4 and H2A contain an identical N-terminal SGRGK sequence …
View article: Effects of Oncohistone Mutations and PTM Crosstalk on the N-terminal Acetylation Activities of NatD
Effects of Oncohistone Mutations and PTM Crosstalk on the N-terminal Acetylation Activities of NatD Open
Acetylation at the α-N-terminus (Nα) is one of the most abundant modifications detected on histone H4 and H2A, which is catalyzed by N-terminal acetyltransferase D (NatD). NatD substrate recognition motif, N-terminal SGRGK, is enriched wit…
View article: Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D Open
Protein N-terminal acetyltransferase D (NatD, NAA40) that specifically acetylates the alpha-N-terminus of histone H4 and H2A has been implicated in various diseases, but no inhibitor has been reported for this important enzyme. Based on th…
View article: Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D
Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D Open
Protein N-terminal acetyltransferase D (NatD, NAA40) that specifically acetylates the alpha-N-terminus of histone H4 and H2A has been implicated in various diseases, but no inhibitor has been reported for this important enzyme. Based on th…
View article: Development of A Continuous Fluorescence-Based Assay for N-Terminal Acetyltransferase D
Development of A Continuous Fluorescence-Based Assay for N-Terminal Acetyltransferase D Open
N-terminal acetylation catalyzed by N-terminal acetyltransferases (NATs) has various biological functions in protein regulation. N-terminal acetyltransferase D (NatD) is one of the most specific NAT with only histone H4 and H2A proteins as…
View article: Development of a continuous fluorescence-based assay for N-terminal acetyltransferase D
Development of a continuous fluorescence-based assay for N-terminal acetyltransferase D Open
N-terminal acetylation catalyzed by N-terminal acetyltransferases (NATs) has various biological functions in protein regulation. N-terminal acetyltransferase D (NatD) is one of the most specific NAT with only histone H4 and H2A proteins as…
View article: Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer Open
We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6 (HDAC6). The most potent and selective compound, 3d (IC50, 4 nM, HDAC6; IC50