Yijun Chen
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View article: Oxycodone reduces postoperative pulmonary complications compared to sufentanil in high-risk patients with pulmonary dysfunction: a randomized clinical trial
Oxycodone reduces postoperative pulmonary complications compared to sufentanil in high-risk patients with pulmonary dysfunction: a randomized clinical trial Open
Registration number: ChiCTR2500099262. Registration date: March 20, 2025(Retrospectively registered).
View article: Hierarchical Ranking Neural Network for Long Document Readability Assessment
Hierarchical Ranking Neural Network for Long Document Readability Assessment Open
Readability assessment aims to evaluate the reading difficulty of a text. In recent years, while deep learning technology has been gradually applied to readability assessment, most approaches fail to consider either the length of the text …
View article: Machine learning-enhanced prediction of fetal growth restriction using fetal cardiac remodeling parameters
Machine learning-enhanced prediction of fetal growth restriction using fetal cardiac remodeling parameters Open
View article: Plasma vs. serum: which is better for proteomic blood biomarker analysis? Evaluation of the novel NULISA platform
Plasma vs. serum: which is better for proteomic blood biomarker analysis? Evaluation of the novel NULISA platform Open
STRUCTURED ABSTRACT INTRODUCTION The NULISASeq™ CNS Disease Panel has high potential for AD diagnosis, but the comparability of serum vs. plasma remains unclear. METHODS We compared its performance on 43 matched serum-plasma pairs from a m…
View article: Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression
Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression Open
Glioblastoma is the most aggressive form of primary brain tumor, characterized with poor prognosis and resistance to conventional therapies. Increasing evidence points to oxidative stress and redox dysregulation as important contributors t…
View article: Impact of the <scp>2025</scp> Lancet Diagnostic Criteria on Obesity Treatment in the United States
Impact of the <span>2025</span> Lancet Diagnostic Criteria on Obesity Treatment in the United States Open
For decades, clinicians have diagnosed obesity using body mass index (BMI). In January 2025, the updated Lancet guideline recommended the use of anthropometric index in addition to BMI. It also recommended routine treatment for clinical ob…
View article: Pathogenicity and transmission of Morganella morganii in honey bees
Pathogenicity and transmission of Morganella morganii in honey bees Open
Honey bees provide essential pollination services in the ecosystem. The high annual loss of honey bees has raised concerns about global food security and the agricultural economy. As a primary stressor causing colony failure, the mite Varr…
View article: Cerebello-cortical inhibition underlies the effects of cerebellar magnetic stimulation on spinocerebellar ataxia type 3: A randomized controlled trial
Cerebello-cortical inhibition underlies the effects of cerebellar magnetic stimulation on spinocerebellar ataxia type 3: A randomized controlled trial Open
Our findings indicate that cerebellar iTBS alleviates clinical ataxia severity in SCA3 potentially by restoring cerebello-cortical inhibition and reorganizing beta-band activity. N45 amplitude may serve as a potential biomarker for treatme…
View article: Dual metabolic-inflammation modulation in MicroRNA@neutrophil-derived microvesicles achieve robust osteoarthritis therapy
Dual metabolic-inflammation modulation in MicroRNA@neutrophil-derived microvesicles achieve robust osteoarthritis therapy Open
View article: Pharmacokinetic and pharmacodynamic studies of injectable nocathiacin as a novel antibacterial agent
Pharmacokinetic and pharmacodynamic studies of injectable nocathiacin as a novel antibacterial agent Open
The extreme hydrophobicity of nocathiacin, a potent thiopeptide antibiotic against multidrug-resistant (MDR) Gram-positive pathogens, has limited its clinical development. This study formulated an injectable lyophilized nocathiacin with en…
View article: Gene conversion-associated successive engineering of modular polyketide synthases
Gene conversion-associated successive engineering of modular polyketide synthases Open
Modular polyketide synthases (PKSs) can produce various secondary metabolites in a collinearity fashion. Although rational engineering of modular PKS can ultimately create a diverse array of compounds, de novo generation of defined structu…
View article: Cost shifting or cost cutting by hospitals as a response to reimbursement reform? The case of diagnosis-related groups (DRG) scheme in China
Cost shifting or cost cutting by hospitals as a response to reimbursement reform? The case of diagnosis-related groups (DRG) scheme in China Open
Background Diagnosis-related group (DRG) systems for healthcare reimbursement were recently introduced among hospitals in China, raising concerns about cost-shifting, where hospitals may increase charges for self-financing patients to offs…
View article: The Role of the ALDH Family in Predicting Prognosis and Therapy Response in Pancreatic Cancer
The Role of the ALDH Family in Predicting Prognosis and Therapy Response in Pancreatic Cancer Open
Background: Pancreatic cancer ranks as the fourth leading cause of cancer-related deaths in the USA. The human aldehyde dehydrogenase (ALDH) family comprises 19 functional members and has been implicated in prognosis and therapy resistance…
View article: Tribological enhancement of seal blocks using petrochemical diesel carbonaceous particles
Tribological enhancement of seal blocks using petrochemical diesel carbonaceous particles Open
Polymeric sealing materials are essential in industrial systems; however, their tribological limitations under harsh conditions often lead to premature failure. This study presents a cost-effective approach to enhancing the friction and we…
View article: A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance Open
View article: Operating Performance Analysis of H Company Based on the REVA Model
Operating Performance Analysis of H Company Based on the REVA Model Open
Against the backdrop of digital transformation, the limitations of traditional financial indicators in valuing asset-light enterprises have become increasingly apparent. Taking H Company as the research subject, this paper introduces the R…
View article: Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay
Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay Open
Background: Brain-derived tau (BD-tau) is a promising blood-based biomarker for neurodegeneration/brain injury in neurodegenerative and acute neurological disorders. However, widespread use is hampered by lack of commercial assays. Methods…
View article: The Role of the ALDH Family in Predicting Prognosis and Therapy Response in Pancreatic Cancer
The Role of the ALDH Family in Predicting Prognosis and Therapy Response in Pancreatic Cancer Open
Background: Pancreatic cancer ranks as the fourth leading cause of cancer-related deaths in the USA. The human aldehyde dehydrogenase (ALDH) family comprises 19 functional members and has been implicated in prognosis and therapy resistance…
View article: Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid
Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid Open
Pulmonary arterial hypertension (PAH) is marked by elevated vascular resistance, right ventricular (RV) failure, and poor clinical outcomes. Current therapies primarily target pulmonary vascular hemodynamics, necessitating novel strategies…
View article: 394P Reactive cutaneous capillary endothelial proliferation in esophageal squamous cell carcinoma patients treated with camrelizumab-based therapy: A pooled analysis of two phase III trials
394P Reactive cutaneous capillary endothelial proliferation in esophageal squamous cell carcinoma patients treated with camrelizumab-based therapy: A pooled analysis of two phase III trials Open
View article: Spatiotemporal Analysis of Sea-Surface pH in the Pacific Ocean Based on Interpretable Machine Learning
Spatiotemporal Analysis of Sea-Surface pH in the Pacific Ocean Based on Interpretable Machine Learning Open
Increasingly severe ocean acidification (OA) disrupts the balance of marine ecosystems. Seawater pH is a key indicator of OA but remains challenging to characterize due to sparse and limited in situ observations. In this study, we propose …
View article: Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice
Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice Open
Introduction Shexiang Tongxin Dropping Pills (STDP), a traditional Chinese medicine (TCM), is clinically used for cardiovascular diseases like myocardial ischemia. Myocardial ischemia-reperfusion injury (MIRI), worsened by oxidative stress…
View article: Incidental Finding of a Primary Polypoid Low-Grade B-Cell Gastric Lymphoma Managed with Chemotherapy
Incidental Finding of a Primary Polypoid Low-Grade B-Cell Gastric Lymphoma Managed with Chemotherapy Open
BACKGROUND This report describes the case of a 57-year-old man with an incidental finding of a primary polypoid low-grade B-cell gastric lymphoma managed with chemotherapy. The case has unique clinical features and represents an uncommon m…
View article: Coordination between flood prevention capacity and urbanization under climate change in the Yangtze River Economic Belt, China
Coordination between flood prevention capacity and urbanization under climate change in the Yangtze River Economic Belt, China Open
Under the impact of increasingly uncertain climate change, flood prevention capacity (FPC) in the process of urbanization has attracted more attention. Therefore, this study constructed a framework to explore the coordination relationship …
View article: Role of FPR2 antagonism in alleviating social isolation-induced depression and protecting blood-brain barrier integrity
Role of FPR2 antagonism in alleviating social isolation-induced depression and protecting blood-brain barrier integrity Open
Social isolation (SI) is a prevalent issue in modern society, particularly exacerbated during the COVID-19 pandemic, and it is a significant contributor to depressive disorders. Inflammation-related markers are upregulated in patients with…
View article: Mitochondrial PGAM5 modulates methionine metabolism and feather follicle development by targeting Wnt/β-catenin signaling pathway in broiler chickens
Mitochondrial PGAM5 modulates methionine metabolism and feather follicle development by targeting Wnt/β-catenin signaling pathway in broiler chickens Open
View article: Blood biomarkers differentiate AD‐related versus non‐AD‐related cognitive deficits
Blood biomarkers differentiate AD‐related versus non‐AD‐related cognitive deficits Open
INTRODUCTION The utility of blood‐based biomarkers for discriminating Alzheimer's disease (AD)‐related versus non‐AD‐related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability of blood m…
View article: Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort
Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort Open
INTRODUCTION Proteomic evaluation of plasma samples could accelerate the identification of novel Alzheimer's disease (AD) biomarkers. We evaluated the novel NUcleic acid Linked Immuno‐Sandwich Assay (NULISA) proteomic method in an ethnical…
View article: The invisible threat: A 30-year review of air pollution's impact on diarrhoea from the global burden of disease study 2021
The invisible threat: A 30-year review of air pollution's impact on diarrhoea from the global burden of disease study 2021 Open
Although the global burden of diarrhoea caused by air pollution has decreased in the past 30 years, it remains an important public health issue in low and low-middle SDI regions. The research findings emphasize the importance of public hea…
View article: Study on Financial Risk Prevention of NIO in the Context of Big Data
Study on Financial Risk Prevention of NIO in the Context of Big Data Open
With the continuous advancement of global informatization, the way of enterprise financial management under the big data environment is undergoing profound changes. This paper takes NIO as the research object to explore how to prevent fina…