Yi‐Ling Chen
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View article: Suppression of STK11 induces expansion of polymorphonuclear myeloid-derived suppressive cells and activation of immune signaling in breast cancer
Suppression of STK11 induces expansion of polymorphonuclear myeloid-derived suppressive cells and activation of immune signaling in breast cancer Open
The tumor microenvironment in breast cancer is typically immunosuppressive. Combined neoadjuvant chemotherapy and immunotherapy is the standard of care for high-risk, triple-negative breast cancer patients, but it is not routinely applied …
View article: Double gene overexpression of ZNF746 and cellular prion protein in rat adipose-derived mesenchymal stromal cell therapy protects the liver against ischemia‒reperfusion injury
Double gene overexpression of ZNF746 and cellular prion protein in rat adipose-derived mesenchymal stromal cell therapy protects the liver against ischemia‒reperfusion injury Open
This study presents an examination of whether the double overexpression of ZNF746 and cellular prion protein (PrP C ) genes in rat adipose-derived mesenchymal stromal cells (ADMSCs) (ie, MSC DGe-OVE ) offered enhanced protection to the liv…
View article: SCH79797, an Antiplatelet Agent, Alleviates Restenosis by Inducing Apoptosis via p53-Mediated Mitochondrial Depolarization and Inhibiting Thrombus Formation after Angioplasty
SCH79797, an Antiplatelet Agent, Alleviates Restenosis by Inducing Apoptosis via p53-Mediated Mitochondrial Depolarization and Inhibiting Thrombus Formation after Angioplasty Open
Introduction: In the field of interventional cardiology, coronary in-stent restenosis (ISR) continues to present a clinical hurdle, even with the progress made in stent design and pharmacological interventions. While drug-eluting stents (D…
View article: Association of Continued Breastfeeding with Micronutrient Status, Thyroid Function, and Cognitive Development in Toddlers
Association of Continued Breastfeeding with Micronutrient Status, Thyroid Function, and Cognitive Development in Toddlers Open
Background : To investigate the associations of continued breastfeeding with micronutrient status, thyroid function, and cognitive development in toddlers. Methods: In this cross-sectional study, 110 toddlers aged 1–2 years were recruited …
View article: Disrupting DDB2-DNA Interaction by Lapatinib Enhances Chemotherapy Sensitivity
Disrupting DDB2-DNA Interaction by Lapatinib Enhances Chemotherapy Sensitivity Open
Chemoresistance remains an obstacle to effective cancer therapy across multiple tumor types. Damaged DNA-binding protein 2 (DDB2), a key component of the nucleotide excision repair (NER) pathway, contributes to chemoresistance by enhancing…
View article: Predictive Value of APACHE II, Extravascular Lung Water Index, and Total Bilirubin for 28-Day Mortality in Mechanically Ventilated Septic Patients
Predictive Value of APACHE II, Extravascular Lung Water Index, and Total Bilirubin for 28-Day Mortality in Mechanically Ventilated Septic Patients Open
This retrospective case-control study enrolled 119 adult septic patients on MV from March 2023 to October 2024 . Among the 119 enrolled patients, 36 (30.3%) died within 28 days of MV. Multivariate logistic regression identified the followi…
View article: Correction: Comparison of outcome between sole operation and operation after tube thoracostomy in late phase empyema
Correction: Comparison of outcome between sole operation and operation after tube thoracostomy in late phase empyema Open
View article: Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification
Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification Open
Current therapies show limited efficacy for advanced hepatocellular carcinoma (HCC). This study demonstrates that targeting the mevalonate pathway induces ferroptosis in HCC by disrupting CoQ10 biosynthesis and selenoprotein translation. C…
View article: Correlation between fetal-placental doppler indices and maternal cardiac function in pregnant women with late-Onset preeclampsia or fetal growth restriction
Correlation between fetal-placental doppler indices and maternal cardiac function in pregnant women with late-Onset preeclampsia or fetal growth restriction Open
BACKGROUND: Fetal growth restriction (FGR) and late-onset preeclampsia (late-onset PE) reflect placental dysfunction but exhibit distinct maternal hemodynamics within the “maternal cardiovascular-placental-fetal unit”. INTRODUCTION: Our ob…
View article: Numerical analysis of the effect of vegetation root reinforcement on the rainfall-induced instability of loess slopes
Numerical analysis of the effect of vegetation root reinforcement on the rainfall-induced instability of loess slopes Open
View article: The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in chronic hepatitis B: a novel diagnostic and prognostic indicator
The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in chronic hepatitis B: a novel diagnostic and prognostic indicator Open
BACKGROUND: Chronic hepatitis B (CHB) is a major health problem worldwide and is a major contributor to the progression of cirrhosis and hepatocellular carcinoma (HCC). Accurate monitoring of the immune response and liver inflammation in C…
View article: Efficacy and safety of cisplatin + docetaxel + 5-FU + leucovorin + methotrexate and epirubicin combination chemotherapy for advanced esophageal cancer
Efficacy and safety of cisplatin + docetaxel + 5-FU + leucovorin + methotrexate and epirubicin combination chemotherapy for advanced esophageal cancer Open
ion Esophageal cancer is a devastating disease. The cisplatin and 5-FU regimen is the most widely used concurrent chemoradiotherapy protocol for metastatic, unresectable advanced esophageal cancer in Asia. However, its effectiveness remain…
View article: Multidisciplinary tumour boards and surgical intervention improve overall survival in patients with Stage III non-small-cell lung cancer: a retrospective cohort study
Multidisciplinary tumour boards and surgical intervention improve overall survival in patients with Stage III non-small-cell lung cancer: a retrospective cohort study Open
OBJECTIVES Given the poor outcomes and treatment complexities in Stage III non-small-cell lung cancer (NSCLC)—especially in challenging subgroups—we aimed to assess whether a multidisciplinary tumour board (MTB) approach combined with surg…
View article: Identification of hub gene for the pathogenic mechanism and diagnosis of MASLD by enhanced bioinformatics analysis and machine learning
Identification of hub gene for the pathogenic mechanism and diagnosis of MASLD by enhanced bioinformatics analysis and machine learning Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous disease caused by multiple etiologies. It is characterized by excessive fat accumulation in the liver. Without intervention, MASLD can progress from steato…
View article: Seizure frequency, APOE ε4, and cognitive function in older people with epilepsy
Seizure frequency, APOE ε4, and cognitive function in older people with epilepsy Open
Background Cognitive impairment represents a major comorbidity among older adults with epilepsy. This study aimed to explore the association between the apolipoprotein E ( APOE ) ε4 allele and cognitive function in older people with epilep…
View article: Evaluation and Validation of Urban Ventilation Potential for Heat Mitigation
Evaluation and Validation of Urban Ventilation Potential for Heat Mitigation Open
Improving urban heat environments through enhanced ventilation has become a critical strategy for mitigating heat stress in the context of climate change. Taiwan’s high-density urban development and tightly packed buildings create signific…
View article: Urban Heat Island Intensity and adapted policy in Taiwan
Urban Heat Island Intensity and adapted policy in Taiwan Open
The urban heat island (UHI) effect, exacerbated by climate change, poses a growing challenge to urban living conditions in Taiwan. With its unique topography featuring steep elevation changes—from sea level to 3950 meters within just 140 k…
View article: Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats
Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats Open
Background Methamphetamine (MA) is one of the most harmful synthetic drugs, yet the mechanisms underlying its addiction and relapse remain incompletely understood. This study investigates how cardiomyocyte-derived exosomes carrying miRNAs …
View article: Risk factors and prognostic predictors of recurrent bacterial empyema in patients after surgical treatment
Risk factors and prognostic predictors of recurrent bacterial empyema in patients after surgical treatment Open
View article: Correlation between Fetal-Placental Doppler Indices and Maternal Cardiac Function in Pregnant Women with Late-Onset Preeclampsia or Fetal Growth Restriction
Correlation between Fetal-Placental Doppler Indices and Maternal Cardiac Function in Pregnant Women with Late-Onset Preeclampsia or Fetal Growth Restriction Open
Introduction To investigate the correlation between fetal-placental Doppler indices and maternal cardiac function in pregnant women with late-onset preeclampsia (PE) or fetal growth restriction (FGR). Methods A total of 90 pregnant women a…
View article: Comparison of outcome between sole operation and operation after tube thoracostomy in late phase empyema
Comparison of outcome between sole operation and operation after tube thoracostomy in late phase empyema Open
Empyema is a severe and potentially life-threatening condition characterized by infection in the pleural cavity with pus collection. Treatment options include antibiotics, tube thoracostomy, video-assisted thoracic surgery (VATS) decortica…
View article: Multicomponent exercise improved cognitive flexibility and muscular fitness in community-dwelling older adults
Multicomponent exercise improved cognitive flexibility and muscular fitness in community-dwelling older adults Open
Objective Cognitive flexibility is the ability to transition between various tasks flexibly, which declines in aging. The purpose of this quasi-experimental study was to investigate the effect of a 12-week multicomponent exercise intervent…
View article: Based on network pharmacology and molecular docking technology to explore the pharmacodynamic components and mechanism of Gynostemmae Pentaphylli Herba reversing Cervical intraepithelial neoplasia
Based on network pharmacology and molecular docking technology to explore the pharmacodynamic components and mechanism of Gynostemmae Pentaphylli Herba reversing Cervical intraepithelial neoplasia Open
View article: Cell Sizes Matter for Industrial Bioproduction, a Case of Polyhydroxybutyrate
Cell Sizes Matter for Industrial Bioproduction, a Case of Polyhydroxybutyrate Open
Most bacterial cells are 1–2 microns in size, limiting intracellular products like polyhydroxyalkanoates (PHA) accumulation. Cell size is regulated by key genes such as mreB and minCD , which encode cellular skeleton protein and control ce…
View article: Role of respiratory secretion culture in the surgical outcome prediction of bacterial empyema
Role of respiratory secretion culture in the surgical outcome prediction of bacterial empyema Open
Objectives Thoracic empyema is a serious infection. Video-assisted thoracoscopic surgery is a recommended treatment, and pleural fluid and tissue cultures are collected intraoperatively. The combination of a pleural peels tissue culture an…
View article: Correlation filter object tracking algorithm based on spatial and channel attention mechanism
Correlation filter object tracking algorithm based on spatial and channel attention mechanism Open
View article: Circulating <scp>CD3</scp> <sup>+</sup> <scp>CD8</scp> <sup>+</sup> T Lymphocytes as Indicators of Disease Status in Patients With Early Breast Cancer
Circulating <span>CD3</span> <sup>+</sup> <span>CD8</span> <sup>+</sup> T Lymphocytes as Indicators of Disease Status in Patients With Early Breast Cancer Open
Background Identifying breast cancer markers with superior sensitivity, cost‐effectiveness, and practicality is imperative. Circulating immune cells and plasma cytokines hold promise as potential breast cancer markers. Aims To search and v…
View article: Identification and evaluation of plasma exosome RNA biomarkers for non-invasive diagnosis of hepatocellular carcinoma using RNA-seq
Identification and evaluation of plasma exosome RNA biomarkers for non-invasive diagnosis of hepatocellular carcinoma using RNA-seq Open
View article: Network pharmacology, experimental validation and pharmacokinetics integrated strategy to reveal pharmacological mechanism of goutengsan on methamphetamine dependence
Network pharmacology, experimental validation and pharmacokinetics integrated strategy to reveal pharmacological mechanism of goutengsan on methamphetamine dependence Open
Background Goutengsan (GTS) is a traditional Chinese medicine formula that can improve multiple nervous system diseases, such as methamphetamine (MA) dependence. However, the mechanism how GTS treats MA dependence remains unclear. This stu…
View article: Long term outcomes of intracarotid arterial transfusion of circulatory-derived autologous CD34 + cells for acute ischemic stroke patients—A randomized, open-label, controlled phase II clinical trial
Long term outcomes of intracarotid arterial transfusion of circulatory-derived autologous CD34 + cells for acute ischemic stroke patients—A randomized, open-label, controlled phase II clinical trial Open