Yi M. Weaver
YOU?
Author Swipe
View article: Xeroderma pigmentosum protein XPD controls caspase-mediated stress responses
Xeroderma pigmentosum protein XPD controls caspase-mediated stress responses Open
Caspases regulate and execute a spectrum of functions including cell deaths, non-apoptotic developmental functions, and stress responses. Despite these disparate roles, the same core cell-death machinery is required to enzymatically activa…
View article: UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition
UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition Open
UBR5 E3 ligase has been associated with cancer susceptibility and neuronal integrity, with functions in chromatin regulation and proteostasis. However, the functions of ubr5 within animals remain unclear due to lethality in both mammals an…
View article: Proteolytic activation of fatty acid synthase signals pan-stress resolution
Proteolytic activation of fatty acid synthase signals pan-stress resolution Open
Chronic stress and inflammation are not only outcomes of pathological states but rather major drivers of many human diseases 1-4 . Ideally, a given stress program is downregulated to basal levels upon restoration of homeostasis. Chronic re…
View article: Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging
Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging Open
The conserved p38 MAPK family is activated by phosphorylation during stress responses and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune responses and blocks development when hyperactivated. Here we show tha…
View article: Balancing p38 MAPK Signaling with Proteostasis Mechanisms Supports Tissue Integrity during Aging in<i>C. elegans</i>
Balancing p38 MAPK Signaling with Proteostasis Mechanisms Supports Tissue Integrity during Aging in<i>C. elegans</i> Open
Like other p38 MAPKs, C. elegans PMK-1 is activated by phosphorylation during stress responses and inactivated by phosphatases. PMK-1 initiates immune response and blocks development when hyperactivated. Here we show that PMK-1 signaling i…
View article: Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats
Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats Open
Perfluoroalkyl sulfonates (PFSAs) such as perfluorohexane sulfonate (PFHxS) and perfluorooctane sulfonate (PFOS) have very long serum elimination half-lives in humans, and preferentially distribute to serum and liver. The enterohepatic cir…