Ning Xu
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View article: Unlocking the potential of sugarcane: Advances in genomic innovation, biorefinery technologies, and stress resilience, and circular bioeconomy
Unlocking the potential of sugarcane: Advances in genomic innovation, biorefinery technologies, and stress resilience, and circular bioeconomy Open
Sugarcane (Saccharum spp.) is a globally vital crop that plays a central role in sugar production, bioenergy systems, and the emerging circular bioeconomy. While it holds considerable agricultural and industrial importance, its potential i…
View article: AB050. SHR-1316 plus nab-paclitaxel and carboplatin as the first line therapy for advanced, unresectable, recurrent or metastatic thymic carcinoma
AB050. SHR-1316 plus nab-paclitaxel and carboplatin as the first line therapy for advanced, unresectable, recurrent or metastatic thymic carcinoma Open
BACKGROUND: For patients with advanced thymic carcinomas, National Comprehensive Cancer Network (NCCN) guidelines recommend chemotherapy (carboplatin/paclitaxel). But, with the limited efficacy of chemotherapy and high rate of disease prog…
View article: Function of NLRP3 inflammasome activation in multiple myeloma
Function of NLRP3 inflammasome activation in multiple myeloma Open
1. LPS+ATP can activate NLRP3 inflammasome in multiple myeloma cells. 2. Activation of NLRP3 inflammasome inhibits the early apoptosis of myeloma cells induced by dexamethasone and bortezomib.
View article: A lower eGFR <sub>cystatin C</sub> /eGFR <sub>creatinine</sub> ratio is associated with greater cardiovascular risk (higher Framingham Risk Score) in Chinese patients with newly diagnosed type 2 diabetes mellitus
A lower eGFR <sub>cystatin C</sub> /eGFR <sub>creatinine</sub> ratio is associated with greater cardiovascular risk (higher Framingham Risk Score) in Chinese patients with newly diagnosed type 2 diabetes mellitus Open
In the current study, no significant association between SPS and FRS was identified. However, lower eGFRcystatin C/eGFRcreatinine and eGFRcystatin C/eGFRcreatinine≤0.85 were associated with a significantly increased CVD risk in T2DM.
View article: SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia: A long-term study
SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia: A long-term study Open
SGK3 overexpression was detected in the majority of patients with endoscopically resected ESCN and was significantly associated with shortened survival. Thus, it might be a new prognostic factor for ESCN.
View article: Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages
Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages Open
Apolipoprotein M (ApoM) exhibits various anti‐atherosclerotic functions as a component of high‐density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR‐BI) is a classic HDL receptor that mediates selective cholesterol upt…
View article: Additional file 4 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque
Additional file 4 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque Open
Additional file 4. GO analysis of the genes differentially hypomethylated in SYM and ASYM plaques
View article: Additional file 5 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque
Additional file 5 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque Open
Additional file 5. GO analysis of the genes differentially hypermethylated in SYM and ASYM plaques
View article: Additional file 12 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque
Additional file 12 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque Open
Additional file 12. Sequences for primers
View article: Additional file 11 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque
Additional file 11 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque Open
Additional file 11. Distribution of SYM plaques, ASYM plaques, and LIMAs between Human Infinium Methylation 450K and MethylationEPIC BeadChip
View article: Additional file 2 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque
Additional file 2 of DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque Open
Additional file 2. Differentially methylated sites of vulnerable and non-vulnerable plaques
View article: Apolipoprotein M promotes the anti-inflammatory effect of high-density lipoprotein by binding to scavenger receptor BI
Apolipoprotein M promotes the anti-inflammatory effect of high-density lipoprotein by binding to scavenger receptor BI Open
ApoM was expressed on all PBMCs. ApoM interacted with SR-BI on THP-1. ApoM+ HDL has a more significant anti-inflammatory effect than apoM- HDL.
View article: Apolipoprotein M promotes growth and inhibits apoptosis of colorectal cancer cells through upregulation of ribosomal protein S27a
Apolipoprotein M promotes growth and inhibits apoptosis of colorectal cancer cells through upregulation of ribosomal protein S27a Open
Colorectal cancer (CRC) is one of the frequent malignant tumors and has a high mortality-to-incidence ratio. Apolipoprotein M (ApoM), a lipoprotein superfamily member, is primarily bound to high-density lipoprotein (HDL) particles. Our pre…
View article: Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice
Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice Open
Apolipoprotein M (apoM) may serve a protective role in the development of inflammation. Nuclear factor‑κB (NF‑κB) and its downstream factors (including a number of inflammatory cytokines and adhesion molecules) are essential for the regula…
View article: Apolipoprotein M overexpression through adeno‐associated virus gene transfer improves insulin secretion and insulin sensitivity in Goto‐Kakizaki rats
Apolipoprotein M overexpression through adeno‐associated virus gene transfer improves insulin secretion and insulin sensitivity in Goto‐Kakizaki rats Open
Aims/Objective The development of type 2 diabetes is a result of insulin resistance in various tissues, including skeletal muscle and liver. Apolipoprotein M (ApoM) plays an important role in the function of high‐density lipoprotein, and a…
View article: Non-negligible factors in studying the ApoM-S1P axis using EA.hy926 cells
Non-negligible factors in studying the ApoM-S1P axis using EA.hy926 cells Open
EA.hy926 cell line is suitable for investigation of the ApoM-S1P axis in vitro. However, Since EA.hy926 cells expressed endogenous ApoM, C-myc and His tagged proteins, the exogenous recombinant ApoM should not be labeled with C-myc and His…
View article: Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway
Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway Open
Background: Previous clinical studies have suggested that apolipoprotein M (apoM) is involved in glucose metabolism and plays a causative role in insulin sensitivity. Objective: The potential mechanism of apoM on modulating glucose homeost…
View article: Apolipoprotein M could inhibit growth and metastasis of SMMC7721 cells via vitamin D receptor signaling
Apolipoprotein M could inhibit growth and metastasis of SMMC7721 cells via vitamin D receptor signaling Open
Miaomei Yu,1 Lili Pan,1 Chen Sang,2 Qinfeng Mu,1 Lu Zheng,1 Guanghua Luo,1 Ning Xu31Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou 213003, People&rsquo;s Republic of China; 2Department of Cardi…
View article: <p>Apolipoprotein M could inhibit growth and metastasis of SMMC7721 cells via vitamin D receptor signaling</p>
Apolipoprotein M could inhibit growth and metastasis of SMMC7721 cells via vitamin D receptor signaling Open
Objective: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high mortality-to-incidence ratios. Apolipoprotein M (ApoM), a member of the apolipoprotein family, is mainly synthesized in the liver, whereas its r…
View article: Expression of flTF and asTF splice variants in various cell strains and tissues
Expression of flTF and asTF splice variants in various cell strains and tissues Open
Tissue factor (TF) expressed at the protein level includes two isoforms: The membrane‑bound full‑length TF (flTF) and the soluble alternatively spliced TF (asTF). flTF is the major thrombogenic form of TF, whereas asTF is more closely asso…
View article: Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways
Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways Open
Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high‑density lipoprotein (HDL) decreases inflammatory responses via the apoM‑sphingosine‑1‑phosphate (S1P) pathway. The present study further investigated the impor…
View article: Increased CXCL8 Expression Is Negatively Correlated with the Overall Survival of Patients with ER-Negative Breast Cancer
Increased CXCL8 Expression Is Negatively Correlated with the Overall Survival of Patients with ER-Negative Breast Cancer Open
The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.
View article: Apolipoprotein M increases the expression of vitamin D receptor mRNA in colorectal cancer cells detected with duplex fluorescence reverse transcription-quantitative polymerase chain reaction
Apolipoprotein M increases the expression of vitamin D receptor mRNA in colorectal cancer cells detected with duplex fluorescence reverse transcription-quantitative polymerase chain reaction Open
Apolipoprotein M (ApoM) and the vitamin D receptor (VDR) are apolipoproteins predominantly presenting in high-density lipoprotein (HDL) and a karyophilic protein belonging to the steroid‑thyroid receptor superfamily, respectively. Previous…
View article: Uric Acid in the Follow-Up Determines 30% Decline in Estimated GFR Over 2 Years: a Propensity Score Analysis
Uric Acid in the Follow-Up Determines 30% Decline in Estimated GFR Over 2 Years: a Propensity Score Analysis Open
Background/Aims: Higher level of serum uric acid (SUA) predicts early entry to dialysis in chronic kidney disease (CKD) patients. However, a short-term effect of SUA remains to be elucidated using a novel surrogate endpoint. Methods: Japan…