Yiru Wang
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View article: Ultrasound super-resolution microvascular imaging of kidney microvascular alterations in acute kidney injury on a clinical ultrasound scanner
Ultrasound super-resolution microvascular imaging of kidney microvascular alterations in acute kidney injury on a clinical ultrasound scanner Open
This study demonstrates the feasibility of URM in AKI using a conventional clinical ultrasound scanner, with simple examination procedure and post-processing tools. Hence, this technique could be a promising diagnostic tool for qualitative…
View article: Reliable biomarkers for diabetic nephropathy using machine learning-assisted contrast-enhanced ultrasonography and clinical characteristics
Reliable biomarkers for diabetic nephropathy using machine learning-assisted contrast-enhanced ultrasonography and clinical characteristics Open
Objective To utilize machine learning techniques to screen contrast-enhanced ultrasound (CEUS) parameters and clinical characteristics, aiming to differentiate diabetic nephropathy (DN) from non-diabetic renal disease (NDRD) in patients wi…
View article: Manganese-loaded carbon nanoparticles ameliorate ANCA-associated vasculitis by inhibiting ferroptosis
Manganese-loaded carbon nanoparticles ameliorate ANCA-associated vasculitis by inhibiting ferroptosis Open
Antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN), a life-threatening vasculitis manifestation, involves systemic endothelial injury and rapid renal decline. Despite limited therapies, the role of ferroptosis, a n…
View article: Cellular Heterogeneity And Spatial-Temporal Landscapes In Mouse Condylar Cartilage
Cellular Heterogeneity And Spatial-Temporal Landscapes In Mouse Condylar Cartilage Open
Aim or purpose: To explore the cell composition and spatial distribution characteristics of mouse condylar cartilage at different ages by single-cell sequencing technology. Materials and methods: C57BL/6J wild-type mice(3 days, 3 weeks, 8 …
View article: Titanium Catalyzed the Cross‐Coupling of Nitriles and Alkyl Halides for the Synthesis of Ketones
Titanium Catalyzed the Cross‐Coupling of Nitriles and Alkyl Halides for the Synthesis of Ketones Open
Here, a titanium‐catalyzed cross‐coupling of alkyl halides with nitriles under mild reaction conditions for the synthesis of ketones is reported. This reaction is applicable in benzyl halides, allyl halides, which are inactive substrates i…
View article: Gabexate mesylate thermo‐sensitive in‐situ gel is effective for treating grade‐<scp>III</scp> pancreatic trauma in beagle dogs guided by contrast‐enhanced ultrasound
Gabexate mesylate thermo‐sensitive in‐situ gel is effective for treating grade‐<span>III</span> pancreatic trauma in beagle dogs guided by contrast‐enhanced ultrasound Open
Background This study evaluates the efficacy of gabexate mesylate thermosensitive in‐situ gel (GMTI) in the treatment of beagle grade III pancreatic trauma (PT) with the assistance of contrast‐enhanced ultrasound (CEUS) and investigates it…
View article: Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain Open
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Cla…
View article: Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain Open
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Cla…
View article: Intraoperative hypotension and postoperative delirium in elderly male patients undergoing laryngectomy: a single-center retrospective cohort study
Intraoperative hypotension and postoperative delirium in elderly male patients undergoing laryngectomy: a single-center retrospective cohort study Open
Intraoperative hypotension and low education level are associated with an increased risk of POD in elderly male patients undergoing laryngectomy, especially with prolonged surgery duration.
View article: Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain Open
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Cla…
View article: Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain Open
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Cla…
View article: Assessing cardiac function post chemotherapy combined with immune checkpoint inhibitors via automated two-dimensional speckle tracking
Assessing cardiac function post chemotherapy combined with immune checkpoint inhibitors via automated two-dimensional speckle tracking Open
Background Although left ventricular (LV) dysfunction has been studied in patients with solid tumors and abnormal myocardial enzymes receiving immune checkpoint inhibitors, little is known about the early changes in LV strains and function…
View article: Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain Open
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Cla…
View article: An observational study of the pH value during the healing process of diabetic foot ulcer
An observational study of the pH value during the healing process of diabetic foot ulcer Open
The measurement of pH value is efficient and simple, and the patient suffers no discomfort in the process. The change in pH helps predict the healing process of diabetic foot ulcers and quickly identify whether there are key factors such a…
View article: TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux
TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux Open
Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB), remain a global threat exacerbated by increasing drug resistance. Host-directed therapy (HDT) is a promising strategy for infection treatment through t…
View article: Weaver: Foundation Models for Creative Writing
Weaver: Foundation Models for Creative Writing Open
This work introduces Weaver, our first family of large language models (LLMs) dedicated to content creation. Weaver is pre-trained on a carefully selected corpus that focuses on improving the writing capabilities of large language models. …
View article: Identification of potential biomarkers and therapeutic targets for antineutrophil cytoplasmic antibody-associated glomerulonephritis
Identification of potential biomarkers and therapeutic targets for antineutrophil cytoplasmic antibody-associated glomerulonephritis Open
Summary: Exploring key genes for antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (ANCA-GN) is of great significance. Through bioinformatics analysis, 79 immune protein-differentially expressed genes (IP-DEGs) were …
View article: Perceptions of protective shoes and recommendations from patients with diabetic foot ulcers
Perceptions of protective shoes and recommendations from patients with diabetic foot ulcers Open
Development of diabetic foot can cause serious harm to a patient's body and pose a heavy burden on family members and society. Protective shoes are of great significance to preventing diabetic foot. The aim of the current study was to unde…
View article: Association of N-acetylcysteine use with contrast-induced nephropathy: an umbrella review of meta-analyses of randomized clinical trials
Association of N-acetylcysteine use with contrast-induced nephropathy: an umbrella review of meta-analyses of randomized clinical trials Open
Background The effectiveness of N-acetylcysteine (NAC) in treating contrast-induced nephropathy (CIN) has been the subject of conflicting meta-analyses, but the strength of the evidence for these correlations between NAC use and CIN has no…
View article: The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome
The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome Open
Irritable Bowel Syndrome (IBS) is a complex functional gastrointestinal disorder primarily characterized by chronic abdominal pain, bloating, and altered bowel habits. Chronic abdominal pain caused by visceral Hypersensitivity (VH) is the …
View article: Effect of Intraoperative Dexmedetomidine Use on Postoperative Delirium in the Elderly After Laryngectomy: A Randomized Controlled Clinical Trial
Effect of Intraoperative Dexmedetomidine Use on Postoperative Delirium in the Elderly After Laryngectomy: A Randomized Controlled Clinical Trial Open
Intraoperative dexmedetomidine administration did not prevent POD in patients with laryngeal cancer. Dexmedetomidine reduced serum CRP and IL-6 levels postoperatively but caused a higher occurrence of intraoperative hypotension in elderly …
View article: Corrigendum: The effects of Tai Chi on physical function and safety in patients with rheumatoid arthritis: a systematic review and meta-analysis
Corrigendum: The effects of Tai Chi on physical function and safety in patients with rheumatoid arthritis: a systematic review and meta-analysis Open
[This corrects the article DOI: 10.3389/fphys.2023.1079841.].
View article: Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy
Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy Open
Cancer represents one of the leading causes of mortality worldwide. Conventional clinical treatments include radiation therapy, chemotherapy, immunotherapy, and targeted therapy. However, these treatments have inherent limitations, such as…
View article: Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors
Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors Open
Background Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown. Methods Using patch-clamp recording…
View article: MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation Open
Increasing incidence of sensorineural hearing loss (SNHL) has raised concerns over the disease, while the limited treatment options have motivated the study of new biological therapies. Among these, mesenchymal stem cell (MSC) transplantat…
View article: Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson’s Disease
Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson’s Disease Open
Increased oxidative stress and neuroinflammation play a crucial role in the pathogenesis of Parkinson’s disease (PD). In this study, the expression levels of 52 genes related to oxidative stress and inflammation were measured in peripheral…