Explanipedia

Glia inflammation and cell death pathways drive disease progression in preclinical and early AD Open

Marcel S. Woo, Joseph Therriault, Seyyed Ali Hosseini, Yi-Ting Wang, Arthur C. Macedo , et al. · 2025

Accumulation of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) are followed by the activation of glia cells and infiltration of peripheral immune cells that collectively accelerate neurodegeneration in preclinical AD models. Yet, the ro…

Tau profiling across Alzheimer’s disease staging reveals vulnerability to disease pathophysiology Open

Gleb Bezgin, Tharick A. Pascoal, Joseph Therriault, Firoza Z Lussier, Stijn Servaes , et al. · 2025

Diagnosis and prognosis prediction of gastric cancer by high-performance serum lipidome fingerprints Open

Zerong Cai, Wen Wang, Di Chen, Haojie Chen, Yan Hu , et al. · 2024

Early detection is warranted to improve prognosis of gastric cancer (GC) but remains challenging. Liquid biopsy combined with machine learning will provide new insights into diagnostic strategies of GC. Lipid metabolism reprogramming plays…

Different effects of vitamin supplementation on arsenic bioaccessibility in contaminated soils using multiple in vitro methods and their relevant mechanisms Open

Yi Zhou, Yongli Zhao, Peng Xiao, Pengfei Wang, Yunpeng Li , et al. · 2024

Exposure to arsenic (As) induces adverse effects on human health. Vitamins B1, B6, and C, as indispensable micronutrients for humans, have been proven to influence the metabolism and toxicity of ingested As. To determine the effect of vita…

Label-free single-vesicle based surface enhanced Raman spectroscopy: A robust approach for investigating the biomolecular composition of small extracellular vesicles Open

Zirui Liu, Martin Ng, Siddharth Srivastava, Tieyi Li, Jun Liu , et al. · 2024

Small extracellular vesicles (sEVs) are cell-released vesicles ranging from 30-150nm in size. They have garnered increasing attention because of their potential for both the diagnosis and treatment of disease. The diversity of sEVs derives…

In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum Open

Komal Abhange, Reta Birhanu Kitata, Jie Zhang, Yi-Ting Wang, Matthew Gaffrey , et al. · 2023

Extracellular vesicle (EV) secretion has been observed in many types of both normal and tumor cells. EVs contain a variety of distinctive cargoes, allowing tumor-derived serum proteins in EVs to act as a minimally invasive method for clini…

Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes Open

Steven E. Schutzer, Tao Liu, Chia‐Feng Tsai, Vladislav Petyuk, Athena Schepmoes , et al. · 2023

This supports the notion that ME/CFS and fibromyalgia as currently defined are not distinct entities.Key messageME/CFS and fibromyalgia as currently defined are not distinct entities.Unbiased quantitative mass spectrometry-based proteomics…

Validation of a Proteomic Signature of Lung Cancer Risk from Bronchial Specimens of Risk-Stratified Individuals Open

S.M. Jamshedur Rahman, Sheau‐Chiann Chen, Yi-Ting Wang, Yuqian Gao, Athena Schepmoes , et al. · 2023

A major challenge in lung cancer prevention and cure hinges on identifying the at-risk population that ultimately develops lung cancer. Previously, we reported proteomic alterations in the cytologically normal bronchial epithelial cells co…

A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics Open

Chia‐Feng Tsai, Yi-Ting Wang, Chuan‐Chih Hsu, Reta Birhanu Kitata, Rosalie Chu , et al. · 2023

Data for EMSL Project 51127 from April 2023 Open