Yibang Chen
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View article: Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data".
Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data". Open
View article: Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data
Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data Open
The Library of Integrated Network-based Cellular Signatures (LINCS), an NIH Common Fund program, has cataloged and analyzed cellular function and molecular activity profiles in response to >80,000 perturbing agents that are potentially dis…
View article: Multiscale mapping of transcriptomic signatures for cardiotoxic drugs
Multiscale mapping of transcriptomic signatures for cardiotoxic drugs Open
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardi…
View article: Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity
Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity Open
Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers for the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. Its key aim is to generate proteomi…
View article: Multiscale mapping of transcriptomic signatures for cardiotoxic drugs
Multiscale mapping of transcriptomic signatures for cardiotoxic drugs Open
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focused on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced pluripotent stem cell-derived car…
View article: Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset
Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset Open
The Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generat…
View article: Kai‑Xin‑San suppresses matrix metalloproteinases and myocardial apoptosis in rats with myocardial infarction and depression
Kai‑Xin‑San suppresses matrix metalloproteinases and myocardial apoptosis in rats with myocardial infarction and depression Open
Depression is often triggered by prolonged exposure to psychosocial stressors and associated with coronary heart disease (CHD). Matrix metalloproteinases (MMPs) are involved in the pathogenesis of various emotional and cardiovascular disor…
View article: Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses
Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses Open
The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop transcriptomic s…
View article: Systems therapeutics analyses identify genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer
Systems therapeutics analyses identify genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer Open
The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop genomic signatur…
View article: Cell shape information is transduced through tension-independent mechanisms
Cell shape information is transduced through tension-independent mechanisms Open
View article: Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability
Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability Open
Kidney podocytes’ function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynami…
View article: A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction
A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction Open
View article: Chaotic propagation of spatial cytoskeletal instability modulates integrity of podocyte foot processes
Chaotic propagation of spatial cytoskeletal instability modulates integrity of podocyte foot processes Open
The kidney podocyte’s function depends on its distinctive morphology. Each podocyte has fingerlike projections, called foot processes, that interdigitate with the processes of neighboring cells to form the glomerular filtration barrier. Th…