Explanipedia

Narrowing Regional Gaps: A Study on the Strategies for Balanced Development of Regional Education in China Open

Siqi Wang, Yuanyuan Jia, Guang Gao, Chang Tian, Yu Feng , et al. · 2025

By comprehensively analyzing the current status of education development and the achievements of economic development in China, this paper reveals the synergistic effect between the overall improvement of education levels and economic grow…

Cancer-associated fibroblast miR-148a-5p/CALD1/collagen VI pathway promotes proliferation in Helicobacter pylori-positive gastric cancer Open

Qiuyu Jiang, Hao Zhang, Yu‐Dong Cai, Fansheng Meng, Huibin Wu , et al. · 2025

Hp-stimulated CAFs played a significant role in promoting tumor proliferation in Hp + GC. Targeting its "TLR/miR-148a-5p/CALD1/collagen VI" pathway was a promising method to ease the collagen-rich microenvironment and inhibit the prolifera…

Association of EIF4G1 Gene Variants with Sporadic Parkinson’s disease in a Chinese Han Population Open

Li Jin, Yu‐Dong Cai, Zhu Si, Lin Lu, Zhiling Zhang , et al. · 2025

Eukaryotic translation initiation factor 4G1 (eIF4G1) has been implicated in Parkinson’s disease (PD) pathogenesis. However, the contribution of EIF4G1 genetic variation to PD susceptibility remains unclear. To investigate the association …

Trends and hotspots in research of virus and gastrointestinal mucosal immunity: a bibliometric analysis of four decades Open

Yu‐Dong Cai, Jingqi Liu, Mingxia Zhang, Nianhong Qin, Mingfeng Liao , et al. · 2025

This bibliometric analysis provides insights into research trends and emerging hotspots in the field of viruses and GI mucosal immunity, aiding researchers in identifying key areas for future investigation.

Integrated single-cell and bulk RNA-seq analysis reveals prognostic stemness genes in leiomyosarcoma Open

Aiju Lou, Yu‐Dong Cai, Tianqi Zheng, Long Zhang, Yupeng Hu , et al. · 2025

Introduction Leiomyosarcoma (LMS) is a rare and aggressive soft tissue sarcoma with limited therapeutic options and poor prognosis. Identifying reliable prognostic markers and therapeutic targets is critical for improving personalized trea…

High-quality polarization 3D reconstruction of weakly textured objects by fusing multi-view images Open

Jintao Zhu, Liang Peng, Hui Du, Zhiqiang Liu, Yu‐Dong Cai , et al. · 2025

Multi-view stereo (MVS) estimates depth by matching features across calibrated views. Though highly accurate on textured surfaces, it is prone to holes and coarse geometry in the case of weak textures or limited viewpoints. Shape-from-pola…

Boron Difluoride Formazanate Dye With Donor Planarization Engineering for 1060 nm Laser Activated Photothermal Theranostics Open

Kang Xu, Min Luo, Weili Wang, Tian Zhang, Chen Yang , et al. · 2025

Phototheranostics within the second near‐infrared (NIR‐II, 1000–1700 nm) window offer considerable advantages compared to those operating in the visible and first near‐infrared region (NIR‐I, 700–900 nm). Herein, a donor‐acceptor‐donor (D‐…

Unveiling Immune Response Mechanisms in Mpox Infection Through Machine Learning Analysis of Time Series Gene Expression Data Open

Qinglan Ma, Xianchao Zhou, Lei Chen, Kaiyan Feng, Yusheng Bao , et al. · 2025

Monkeypox virus (Mpox) has recently drawn global attention due to outbreaks beyond its traditional endemic regions. Understanding the immune response to Mpox infection is essential for improving disease management and guiding vaccine devel…

Advances in mRNA-LNP lung-targeted delivery strategies Open

Xu Liu, Shuhan Ji, Yu‐Dong Cai, Fuchun Yang, Jian You , et al. · 2025

The lung, a vital organ for homeostasis, is vulnerable to various diseases that challenge healthcare systems due to limited treatment options. Fortunately, mRNA-based gene therapy offers a promising solution, demonstrating high efficiency …

Transcriptomic and miRNA Signatures of ChAdOx1 nCoV-19 Vaccine Response Using Machine Learning Open

Jinting Lin, Qinglan Ma, Lei Chen, Wei Guo, Kaiyan Feng , et al. · 2025

Vaccination with ChAdOx1 nCoV-19 is an important countermeasure to fight the COVID-19 pandemic. This vaccine enhances human immunoprotection against SARS-CoV-2 by inducing an immune response against the SARS-CoV-2 S protein. However, the i…

Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway Open

Zhixiong Jiang, Yating Yang, Jiahui Zhou, Xin Li, Qingqing Meng , et al. · 2025

Background Esophageal squamous cell carcinoma (ESCC) ranks among the most prevalent malignancies of the digestive tract. Due to the absence of obvious symptoms in patients with early-stage ESCC, most cases are diagnosed at advanced stages,…

Clinical Advances in Esophageal Anti-reflux Stents Open

Yongqi Dang, Fende Liu, Aiai Yan, Cai-Feng Xu, Yang Xu , et al. · 2025

As an emerging treatment, esophageal anti-reflux stent has gradually become the palliative treatment of choice for many digestive diseases due to its features of low trauma, high safety, and conformity to the physiological and anatomical s…

Simulink modeling of an ejector based on CFD simulation Open

Junjie Xue, Qinghuang Huang, Peiyong Wang, Yu‐Dong Cai · 2025

A modeling and simulation study is conducted on a supersonic ejector. CFD simulations are carried out to examine the performance of the ejector, considering water vapor in the secondary flow. First, the study investigates how the compositi…

AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep Open

Hui Xu, Yu‐Dong Cai, Hua Yang, Chong Zhang, Wanru Liu , et al. · 2025

Anti-Müllerian Hormone (AMH), secreted by granulosa cells (GCs) of preantral follicles, regulates early-stage follicle growth by inhibiting the activation of primordial follicles. While GCs facilitate follicle development and ovulation thr…

Overall emissivity of S-type thermocouple with spherical bead Open

Yu‐Dong Cai, Qinghuang Huang, Peiyong Wang, Junjie Xue · 2025

The reading of a thermocouple is its bead temperature, which is normally not equal to the actual gas temperature because of the radiation loss and conduction loss of the bead. Since surface radiation contributes most of the heat loss of a …

WISP: Image Segmentation-Based Whitespace Diagnosis for Optimal Rectilinear Floorplanning Open

Xiaotian Zhao, Zixuan Li, Yu‐Dong Cai, Xinfei Guo · 2025

The increasing number of rectilinear floorplans in modern chip designs presents significant challenges for traditional macro placers due to the additional complexity introduced by blocked corners. Particularly, the widely adopted wirelengt…

Mining and characterization of key amine oxidases from Saccharopolyspora hirsuta T14 based on full homology modeling, transcriptional analysis, and applications in huangjiu Open

Qilin Yang, Shuangping Liu, Anthony M. Sun, Yang Bai, Yu‐Dong Cai , et al. · 2025

PickMe : Sample Selection for Species Tree Reconstruction using Coalescent Weighted Quartets Open

Joseph Rusinko, Yu‐Dong Cai, Allison Crysler, Katherine Thompson, Julien Boutte , et al. · 2025

After collecting large datasets for phylogenomics studies, researchers must decide which genes or samples to include when reconstructing a species tree. Incomplete or unreliable datasets make the empiricist’s decision more difficult. Resea…

The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation Open

Rong Xiao, Xu Pei, Xiangyuan Li, Feng Shen, Shuangfen Tao , et al. · 2025

Background Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignancy with a 5—year survival rate of less than 20%, largely due to its high propensity for metastasis and recurrence. There is an urgent need to identify targeted…

Integrative single-cell transcriptomics of sheep ovarian development reveals dynamic transcriptional programs relevant to reproductive traits Open

Bingru Zhao, Keke Dai, Shanglai Li, Guomin Zhang, Wen-Li Lv , et al. · 2025

CNNeoPP: A Deep Learning Pipeline for Personalized Neoantigen Prediction and Liquid Biopsy Applications Open

Yu‐Dong Cai, Rui Chen, Mingming Song, Lei Wang, Zirong Huo , et al. · 2025

Neoantigens have emerged as promising targets for personalized cancer immunotherapy. However, accurate identification of immunogenic neoantigens remains a challenge due to limitations in existing predictive models. Here, we present CNNeo, …

Chromosome-level genome assembly of Eimeria tenella at the single-oocyst level Open

Kaihui Zhang, Yu‐Dong Cai, Yuancai Chen, Yin Fu, Zhenyu Zhu , et al. · 2025

This high-quality genome assembly and the established sequencing strategy provide valuable community resources for comparative genomic and evolutionary analyses of the Eimeria clade. Additionally, our study also provides a valuable resourc…

Individualized Nutritional Support Improves Cardiac Function and Nutritional Status of Elderly Heart Failure Patients Open

Hang Chen, Ping Xu, Jia Hu, Haipeng Li, Yan Yuan , et al. · 2025

Background The quality of life of the patient is diminished by chronic heart failure (CHF), which also costs the healthcare system. This study examined the benefits of individualized nutritional support provided by a specialized nursing te…

Improving Acoustic Side-Channel Attacks on Keyboards Using Transformers and Large Language Models Open

Jongho Park, Seyyed Ali Ayati, Yu‐Dong Cai · 2025

The increasing prevalence of microphones in everyday devices and the growing reliance on online services have amplified the risk of acoustic side-channel attacks (ASCAs) targeting keyboards. This study explores deep learning techniques, sp…

Robust Reinforcement Learning Control Framework for a Quadrotor Unmanned Aerial Vehicle Using Critic Neural Network Open

Yu‐Dong Cai, Yefeng Yang, Tao Huang, Boyang Li · 2025

This article introduces a novel robust reinforcement learning (RL) control scheme for a quadrotor unmanned aerial vehicle (QUAV) under external disturbances and model uncertainties. First, the translational and rotational motions of the QU…

Positive feedback loop between NRASQ61R mutation and RAB27B expression in endothelial cells Open

Zhi‐Zheng Li, Yu‐Dong Cai, Tiantian Wang, Shuai Peng, Jihong Zhao , et al. · 2025

Achieving Simultaneous Control of Void Formation and Shell Thickness in Core-Shell Structured Si@SiOx Anode Open

Run Ma, Jiakang Xu, Yingxian Wang, Yu‐Dong Cai, Kai Wang , et al. · 2025

Study on the Selection and Compilation of the Book of Songs in International Chinese Cultural Textbooks Open

Yu‐Dong Cai · 2025

A Multi-Mode Switching Energy Management Strategy Based on Travel Habits for Range-Extended Electric Vehicle Open

Zhenhai Gao, Guoqing Zhang, Hanwu Liu, Cheng Chang, Jingwen Dong , et al. · 2025

To achieve the optimal energy allocation for the auxiliary power unit (APU) and battery of a range-extended electric vehicle (REEV), a travel habit-based multi-mode switching energy management strategy (M-MSEMS) has been introduced. REEV h…

Achieving Simultaneous Control of Void Formation and Shell Thickness in Core-Shell Structured Si@SiOx Anode Open

Run Ma, Jiakang Xu, Yingxian Wang, Yu‐Dong Cai, Kai Wang , et al. · 2025

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