Yannong Dou
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View article: Rhizosphere microbes enhance plant resistance to cadmium through a root ROS-microbial IAA-root DNA methylation interkingdom signaling pathway
Rhizosphere microbes enhance plant resistance to cadmium through a root ROS-microbial IAA-root DNA methylation interkingdom signaling pathway Open
Plants deploy a "cry-for-help" strategy to recruit beneficial microbes, thereby enhancing stress resistance and expanding their ecological niches in harsh environments. However, the molecular mechanisms driving this plant-microbe communica…
View article: Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach
Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach Open
Immunotherapy has emerged as a powerful strategy for combating cancer by harnessing the patient's immune system to recognize and eliminate malignant cells. Major histocompatibility complex class I (MHC-I) plays a pivotal role by presenting…
View article: Fork Reversal Safeguards Epigenetic Inheritance during DNA Replication Under Stress
Fork Reversal Safeguards Epigenetic Inheritance during DNA Replication Under Stress Open
During DNA replication, epigenetic information carried by histone modifications is faithfully propagated and re-established on sister chromatids, ensuring cell identity. DNA replication is tightly coupled to chromatin reassembly, therefore…
View article: Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum Stress
Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum Stress Open
SUMMARY Endoplasmic Reticulum (ER) stress disrupts protein homeostasis and impacts protein dynamics, driving cellular responses critical for survival, development and disease. However, no current proteome-wide technology enables simultaneo…
View article: Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury
Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury Open
In recent years, pneumonia caused by multiple viruses has posed a significant threat to public health, particularly affecting vulnerable populations such as the elderly and immunocompromised individuals. Current treatments primarily focuse…
View article: Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception
Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception Open
Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-…
View article: Spatially resolved molecular and cellular atlas of the mouse brain
Spatially resolved molecular and cellular atlas of the mouse brain Open
A comprehensive atlas of genes, cell types, and their spatial distribution across a whole mammalian brain is fundamental for understanding function of the brain. Here, using snRNA-seq and Stereo-seq techniques, we generated a mouse brain a…
View article: PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization
PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization Open
Peripheral sensitization is one of the primary mechanisms underlying the pathogenesis of chronic pain. However, candidate molecules involved in peripheral sensitization remain incompletely understood. We have shown that store-operated calc…
View article: Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons
Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons Open
Group I metabotropic glutamate receptors (group I mGluRs) have been implicated in several central nervous system diseases including chronic pain. It is known that activation of group I mGluRs results in the production of inositol triphosph…
View article: Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids
Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids Open
Mu-opioid receptors (MORs) are crucial for analgesia by both exogenous and endogenous opioids. However, the distinct mechanisms underlying these two types of opioid analgesia remain largely unknown. Here, we demonstrate that analgesic effe…
View article: Curcumin Activates Vagal Afferent Neurons Through the Modulation of Ion Channels via α7 nAChR
Curcumin Activates Vagal Afferent Neurons Through the Modulation of Ion Channels via α7 nAChR Open
Curcumin, a plant polyphenol, has been previously reported to attenuate collagen-induced arthritis in rats by modulating the function of the cholinergic system, but the underlying mechanism remains to be identified. In this study, primary …
View article: Topography of Reward and Aversion Encoding in the Mesolimbic Dopaminergic System
Topography of Reward and Aversion Encoding in the Mesolimbic Dopaminergic System Open
Dopamine (DA) neurons in the VTA play essential roles in adaptive motivated behavior, which requires rapid discrimination between positive and negative motivational signature. However, the precise functional DA circuitry processing reward …
View article: Gut-Sourced Vasoactive Intestinal Polypeptide Induced by the Activation of α7 Nicotinic Acetylcholine Receptor Substantially Contributes to the Anti-inflammatory Effect of Sinomenine in Collagen-Induced Arthritis
Gut-Sourced Vasoactive Intestinal Polypeptide Induced by the Activation of α7 Nicotinic Acetylcholine Receptor Substantially Contributes to the Anti-inflammatory Effect of Sinomenine in Collagen-Induced Arthritis Open
Sinomenine has long been used for the treatment of rheumatoid arthritis in China. However, its anti-inflammatory mechanism is still debatable because the in vitro minimal effective concentration (≥250 μM) is hardly reached in either synovi…
View article: SURF: Understanding and Predicting Urban Convection and Haze
SURF: Understanding and Predicting Urban Convection and Haze Open
Urbanization modifies atmospheric energy and moisture balances, forming distinct features [e.g., urban heat islands (UHIs) and enhanced or decreased precipitation]. These produce significant challenges to science and society, including rap…
View article: Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”
Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis” Open
Our results demonstrate that curcumin attenuates CIA through the "gut-brain axis" by modulating the function of the cholinergic system. These findings provide a novel approach for mechanistic studies of anti-arthritic compounds with low or…
View article: Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability
Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability Open
Pathological pain is a common and debilitating condition that is often poorly managed. Central sensitization is an important mechanism underlying pathological pain. However, candidate molecules involved in central sensitization remain uncl…
View article: Role of extracytoplasmic function sigma factor <scp>PG</scp>1660 (RpoE) in the oxidative stress resistance regulatory network of <i>Porphyromonas gingivalis</i>
Role of extracytoplasmic function sigma factor <span>PG</span>1660 (RpoE) in the oxidative stress resistance regulatory network of <i>Porphyromonas gingivalis</i> Open
Summary In Porphyromonas gingivalis , the protein PG 1660, composed of 174 amino acids, is annotated as an extracytoplasmic function ( ECF ) sigma factor (RpoE homologue‐σ24). Because PG 1660 can modulate several virulence factors and resp…
View article: Tetrandrine, an agonist of aryl hydrocarbon receptor, reciprocally modulates the activities of STAT3 and STAT5 to suppress Th17 cell differentiation
Tetrandrine, an agonist of aryl hydrocarbon receptor, reciprocally modulates the activities of STAT3 and STAT5 to suppress Th17 cell differentiation Open
Tetrandrine, a bisbenzylisoquinoline alkaloid constituent of the root of Stephania tetrandra S. Moore, was previously shown to suppress the differentiation of T helper 17 (Th17) cells and consequently ameliorate the collagen‐induced arthri…
View article: Studies of the extracytoplasmic function sigma factor <scp>PG</scp>0162 in <i>Porphyromonas gingivalis</i>
Studies of the extracytoplasmic function sigma factor <span>PG</span>0162 in <i>Porphyromonas gingivalis</i> Open
Summary PG 0162, annotated as an extracytoplasmic function ( ECF ) sigma factor in Porphyromonas gingivalis , is composed of 193 amino acids. As previously reported, the PG 0162 ‐deficient mutant, P. gingivalis FLL 350 showed significant r…