Explanipedia

Changes in Cardiovascular Risk Factors in U.S. Adults Before and After the COVID-19 Pandemic Open

Huanhuan Yang, Chenxi Huang, Kamil F. Faridi, Mohammed Essa, Devesh Malik , et al. · 2025

Age-Specific Associations Between Adiposity and Mortality in U.S. Adults, 1999-2018 Open

Yuan Lu, Yunhan Mou, Yuntian Liu, Alissa S. Chen, Jeph Herrin , et al. · 2025

A Narrative Review of Mindfulness-Based Interventions for Womens Mental Health Open

Yuan Lu · 2025

Social context, occupational demands, and life-stage transitions all shape womens mental health. This mechanism-driven narrative review primarily examines how mindfulness-based interventions (MBIs) work for women by focusing on the underly…

Quadratic Direct Forecast for Training Multi-Step Time-Series Forecast Models Open

Hao Wang, Linfeng Pan, Yuan Lu, Zhichao Chen, Tianqiao Liu , et al. · 2025

The design of training objective is central to training time-series forecasting models. Existing training objectives such as mean squared error mostly treat each future step as an independent, equally weighted task, which we found leading …

Prescribing of GLP-1 Receptor Agonists for Adolescents with Obesity and Associated Disparities Open

Chungsoo Kim, Mona Sharifi, Joseph S. Ross, Yong Chen, Hua Xu , et al. · 2025

This retrospective cohort study examined national prescribing patterns of glucagon like peptide 1 receptor agonists (GLP1RAs) for U.S. adolescents with obesity using electronic health record data from over 2 million patients aged 12 to 17 …

Comparative Analysis of Long COVID and Post-Vaccination Syndrome: A Cross-Sectional Study of Clinical Symptoms and Machine Learning-Based Differentiation Open

Harlan M. Krumholz, Mitsuaki Sawano, Yilun Wu, Rishi Shah, Tianna Zhou , et al. · 2025

Importance Long COVID is a well-documented post-viral syndrome, while post-vaccination syndrome (PVS) remains poorly characterized. Understanding their similarities and differences is essential for refining diagnostic criteria and developi…

Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide Open

Yuan Lu, Yuntian Liu, Tedi Totojani, Chungsoo Kim, Rohan Khera , et al. · 2025

Importance Semaglutide, a glucagon-like peptide-1 receptor agonist, has demonstrated substantial weight reduction and cardiovascular benefits in clinical trials. However, its association with clinical outcomes and health care expenditures …

Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Open

Mohammad AL Mouslmani, Mitsuaki Sawano, Adith S. Arun, Yilun Wu, Rishi Shah , et al. · 2025

Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes Open

Weilai Dong, Yuan Lu, Shu‐Xia Li, Mitsuaki Sawano, César Caraballo , et al. · 2025

Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes Open

John E. Brush, Chungsoo Kim, Yuntian Liu, Xin Xin, Chenxi Huang , et al. · 2025

Neighborhood-level social vulnerability was strongly associated with adverse cardiovascular outcomes and poorer BP control and may be a driver of racial disparities in hypertension. These findings highlight the potential of leveraging soci…

Hypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic Open

Mohammed Essa, Devesh Malik, Yuan Lu, Huanhuan Yang, Erica S. Spatz , et al. · 2025

Hypertension is a leading cause of death and disability in the United States, but national trends in hypertension after the COVID‐19 pandemic remain unknown. We analyzed NHANES data from pre‐pandemic (2017–March 2020) and post‐pandemic (Au…

Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores Open

Huanhuan Yang, Chenxi Huang, Mitsuaki Sawano, Jeph Herrin, Kamil F. Faridi , et al. · 2025

Importance Significant racial and ethnic differences exist in Life’s Essential 8 (LE8), but the trends in these differences over time are not well understood. Additionally, the key components of LE8 associated with these differences are un…

Lipid-Lowering Therapy in the U.S. Adults Before and After the COVID-19 Pandemic Open

Mohammed Essa, Devesh Malik, Yuan Lu, Huanhuan Yang, Erica S. Spatz , et al. · 2025

Real-world comparative outcomes of GLP-1 RA and semaglutide prescription among individuals with type 2 diabetes Open

Maxwell Salvatore, Bingyu Zhang, Huilin Tang, Yiwen Lu, Dazheng Zhang , et al. · 2025

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for type 2 diabetes (T2D) and weight management, yet their broad health impacts in real- world settings remain understudied. Using data from the All of Us Re…

Trends in Prevalence, Treatment, and Relationship of Metabolic Syndrome and Individual Components by Race/Ethnicity, 1999-2018 Open

Yuan Lu, Xumin Li, Yuntian Liu, César Caraballo, Daisy Massey , et al. · 2025

Comparative Safety of Second-Line Antihyperglycemic Agents in Older Adults with Type 2 Diabetes: A Multinational Real-World Evidence From LEGEND-T2DM Open

Chungsoo Kim, Fan Bu, Clair Blacketer, Anna Ostropolets, Talita Duarte‐Salles , et al. · 2025

Background As prescribing of newer antihyperglycemic agents expands, there remains limited comparative safety data for older adults—a population particularly vulnerable to adverse drug events and underrepresented in clinical trials. We aim…

Predictive value of lymphocyte-to-C-reactive protein ratio for left ventricular thrombus in patients with ST-segment elevation myocardial infarction Open

Xinjia Du, Jiahua Liu, Zeqing Zhang, Yanfei Ren, Lei Chen , et al. · 2025

Background and purpose Current evidence suggested a correlation between inflammation and Left Ventricular Thrombus (LVT). The lymphocyte to C-reactive protein ratio (LCR) has been established as be a reliable inflammation marker and is ass…

Soluble suppression of tumorigenicity 2 associated with left ventricular thrombosis in patients with ST-segment elevation myocardial infarction Open

Xinjia Du, Pardeep Kumar, C Liu, Jiahua Liu, Lei Chen , et al. · 2025

Systolic Blood Pressure and Cardiovascular Mortality in U.S. Adults Aged 80+ Taking Antihypertensive Medications Open

Huanhuan Yang, Chenxi Huang, Mitsuaki Sawano, Jeph Herrin, Guo‐Chong Chen , et al. · 2025

Closing the Gap: Digital Innovations to Address Hypertension Disparities Open

Bassel M. Shanab, Allison E. Gaffey, Lee H. Schwamm, Matthew Zawalich, Daniel F. Sarpong , et al. · 2025

To address hypertension disparities, RBPM programs need to integrate digital technology that is accessible to all users as well as multidisciplinary care teams that attend to the medical and social needs of populations experiencing health …

Revisit to Old Friends: Abdominal and Groin Flaps For Upper Extremity Soft Tissue Reconstruction Open

Uğur Bezirgan, Nevzat Mehmet, Yuan Lu, Osman Talha Nergizal, E. Acaro x F lu , et al. · 2025

Introduction: Soft tissue defects of the upper extremity pose significant challenges in hand surgery. While microsurgical advancements have expanded reconstructive options, pedicled groin and random-pattern abdominal flaps remain valuable …

ViDove: A Translation Agent System with Multimodal Context and Memory-Augmented Reasoning Open

Yuan Lu, Wei Dai, K. Liu, Ching Wing Kwok, Zongheng Wu , et al. · 2025

The Diagnostic Value of Plasma NETs Levels and iCEB in Silent Myocardial Ischemia in Maintenance Hemodialysis Patients Open

Haifei Liu, Jun-Ling Han, Wei‐Jie Ni, Yuan Lu, Xinhui Hu , et al. · 2025

The study highlights the combined diagnostic value of plasma NETs levels and iCEB in identifying SMI in MHD patients, providing valuable insights into potential early detection and risk stratification strategies for this population.

Utilizing the Electronic Health Record to Evaluate Lipoprotein(a) Testing Within a Large Regional Health System Open

Kamil F. Faridi, Qifan Wu, Chungsoo Kim, Erica S. Spatz, Nihar R. Desai , et al. · 2024

Cardiac Biomarkers, Subclinical Brain Vascular Changes, and Cognitive Decline: Post Hoc Analysis of the SPRINT Trial Open

Wenxin Zhang, Simon B. Ascher, Sudipto Dolui, Ilya M. Nasrallah, Yuan Lu , et al. · 2024

Background Subclinical cardiovascular disease (CVD), assessed by high‐sensitivity cardiac troponin T (hs‐cTnT) and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), is linked to cognitive decline, but the associations in hypertensive …

Using Electronic Health Records to Evaluate Treatment Gaps and Disparities in Severe Hypertension Open

Yuan Lu, Yuntian Liu, Chungsoo Kim, Scott Sussman, Ohm Deshpande , et al. · 2024

Trends and Key Contributors of Racial and Ethnic Disparities in Life’s Essential 8: NHANES 2011-2020 Open

Huanhuan Yang, Chenxi Huang, Mitsuaki Sawano, Jeph Herrin, Kamil F. Faridi , et al. · 2024

S IMPORTANCE Significant racial and ethnic differences exist in Life’s Essential 8 (LE8), but the trends in these disparities over time are not well understood. Additionally, the key components of LE8 to these differences are unclear. OBJE…

Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism Open

Behnood Bikdeli, Candrika D. Khairani, Antoine Bejjani, Ying-Chih Lo, Shiwani Mahajan , et al. · 2024

Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic Open

Jeremy Samuel Faust, Benjamin Renton, Tasce Bongiovanni, Alexander Chen, Karen Dorsey Sheares , et al. · 2024

Importance The end of the COVID-19 public health emergency (PHE) provides an opportunity to fully describe pandemic-associated racial and ethnic mortality disparities. Age-specific excess mortality differences have important downstream imp…

Cause-Specific Mortality Rates Among the US Black Population Open

Adith S. Arun, César Caraballo, Mitsuaki Sawano, Yuan Lu, Rohan Khera , et al. · 2024

This cross-sectional study examines the specific causes of death associated with the disparities in all-cause mortality between non-Hispanic Black and non-Hispanic White populations, as well as their changes over time.

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