Yi‐Chien Lee
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View article: Eco-genomic analysis uncovers precision-conservation targets for the western Pacific’s southernmost salmonid
Eco-genomic analysis uncovers precision-conservation targets for the western Pacific’s southernmost salmonid Open
Understanding how isolated small populations persist and adapt in adverse environments is instrumental to evolutionary and conservation biology. We combine a chromosome-level genome assembly, population resequencing and forward-time simula…
View article: Disproportionate presentation of Mpox among people with HIV: A multicenter retrospective cohort study in Taiwan
Disproportionate presentation of Mpox among people with HIV: A multicenter retrospective cohort study in Taiwan Open
Most MPXV infections in Taiwan occur among PWH, particularly those with UDVL. Enhanced screening, vaccination efforts, and integrated STI testing are crucial in addressing this outbreak.
View article: Increased Atherosclerosis in HIV-Infected Humanized Mice Is Caused by a Single Viral Protein, Nef
Increased Atherosclerosis in HIV-Infected Humanized Mice Is Caused by a Single Viral Protein, Nef Open
Antiretroviral therapy suppresses human immunodeficiency virus (HIV) replication, reverses immunodeficiency, and reduces AIDS-related symptoms, but non-AIDS comorbidities like cardiovascular diseases remain a major challenge for people wit…
View article: Echiniscus gemmatussp. nov. (Heterotardigrada: Echiniscidae; the spinulosus morphogroup) from Macau, China
Echiniscus gemmatussp. nov. (Heterotardigrada: Echiniscidae; the spinulosus morphogroup) from Macau, China Open
The study of tardigrades in urban environments, particularly in natural areas within cities, has been significantly overlooked. A recent discovery of a new species of tardigrade in lichens collected from Mong Há Hill Municipal Park in Maca…
View article: Molecular Characterization of High and Low Virulent Escherichia coli Clinical Strains Isolated from Patients with Urinary Tract Infections with or without Bacteremia in Southern Taiwan
Molecular Characterization of High and Low Virulent Escherichia coli Clinical Strains Isolated from Patients with Urinary Tract Infections with or without Bacteremia in Southern Taiwan Open
Taken together, our results provide insights into the contributing factors in patients with UTI and urinary bacteremia.
View article: Comparable clinical outcomes with same-day versus rapid initiation of antiretroviral therapy in Taiwan
Comparable clinical outcomes with same-day versus rapid initiation of antiretroviral therapy in Taiwan Open
SDART and rapid ART initiation resulted in comparable clinical outcomes and viral suppression rates. PWH aged >30 years and GBMSM were less likely to have unfavorable outcomes.
View article: Single-worm long-read sequencing reveals genome diversity in free-living nematodes
Single-worm long-read sequencing reveals genome diversity in free-living nematodes Open
Obtaining sufficient genetic material from a limited biological source is currently the primary operational bottleneck in studies investigating biodiversity and genome evolution. In this study, we employed multiple displacement amplificati…
View article: Whole genome amplification and long read sequencing using ONT v1
Whole genome amplification and long read sequencing using ONT v1 Open
A genome reference is a prerequisite for a complete understanding of the biology and evolution of a species.However, the major challenge remains to obtain high-quality DNA and RNA from the majority of organisms. Therefore, there is a need …
View article: Whole genome amplification and long read sequencing using ONT v2
Whole genome amplification and long read sequencing using ONT v2 Open
A genome reference is a prerequisite for a complete understanding of the biology and evolution of a species.However, the major challenge remains to obtain high-quality DNA and RNA from the majority of organisms. Therefore, there is a need …
View article: Single worm long read sequencing reveals genome diversity in free-living nematodes
Single worm long read sequencing reveals genome diversity in free-living nematodes Open
Obtaining sufficient genetic material from a limited biological source is currently the primary operational bottleneck in studies investigating biodiversity and genome evolution. In this study, we employed multiple displacement amplificati…
View article: Data from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
Data from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited and, very often, ineffective medical and surgical therapeutic options. The treatment of patients with advanced unresectable PDAC is restricted to systemic …
View article: Supplementary Data figures and tables from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
Supplementary Data figures and tables from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells Open
Supplementary Data figures and tables Fig. S1. Genomic characterization of CR cells. Fig. S2. Karyotype analysis of CR cells. Fig. S3. Drug sensitivity profiles of CR cells. Fig. S4. Population doubling times of Parental and nab-paclitaxel…
View article: Data from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
Data from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited and, very often, ineffective medical and surgical therapeutic options. The treatment of patients with advanced unresectable PDAC is restricted to systemic …
View article: Supplementary Data figures and tables from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
Supplementary Data figures and tables from The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells Open
Supplementary Data figures and tables Fig. S1. Genomic characterization of CR cells. Fig. S2. Karyotype analysis of CR cells. Fig. S3. Drug sensitivity profiles of CR cells. Fig. S4. Population doubling times of Parental and nab-paclitaxel…
View article: Cerebral Creatine Deficiency Affects the Timing of Oligodendrocyte Myelination
Cerebral Creatine Deficiency Affects the Timing of Oligodendrocyte Myelination Open
Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior. However, the role of endogenously synthesized creatine on CNS development and functio…
View article: The <i>Aphelenchoides</i> genomes reveal substantial horizontal gene transfers in the last common ancestor of free‐living and major plant‐parasitic nematodes
The <i>Aphelenchoides</i> genomes reveal substantial horizontal gene transfers in the last common ancestor of free‐living and major plant‐parasitic nematodes Open
Aphelenchoides besseyi is a plant‐parasitic nematode (PPN) in the family Aphelenchoididae capable of infecting more than 200 plant species. A. besseyi is also a species complex with strains exhibiting varying pathogenicity to plants. We pr…
View article: Comparable Clinical Outcomes with Same-Day Versus Rapid Initiation of Antiretroviral Therapy: A Real-World Retrospective Cohort Study in a Developed Country
Comparable Clinical Outcomes with Same-Day Versus Rapid Initiation of Antiretroviral Therapy: A Real-World Retrospective Cohort Study in a Developed Country Open
View article: Characteristics and local risk factors of community-acquired and health-care-associated Staphylococcus aureus pneumonia
Characteristics and local risk factors of community-acquired and health-care-associated Staphylococcus aureus pneumonia Open
View article: The<i>Aphelenchoides</i>genomes reveal substantial horizontal gene transfers in the last common ancestor of free-living and major plant parasitic nematodes
The<i>Aphelenchoides</i>genomes reveal substantial horizontal gene transfers in the last common ancestor of free-living and major plant parasitic nematodes Open
Aphelenchoides besseyi is a plant-parasitic nematode (PPN) in the Aphelenchoididae family capable of infecting more than 200 plant species. A. besseyi is also a species complex with strains exhibiting varying pathogenicity to plants. We pr…
View article: Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers
Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers Open
Type 1 Natural Killer T-cells (NKT1 cells) play a critical role in mediating hepatic ischemia-reperfusion injury (IRI). Although hepatic steatosis is a major risk factor for preservation type injury, how NKT cells impact this is understudi…
View article: Opening the Blood Brain Barrier with an Electropermanent Magnet System
Opening the Blood Brain Barrier with an Electropermanent Magnet System Open
Opening the blood brain barrier (BBB) under imaging guidance may be useful for the treatment of many brain disorders. Rapidly applied magnetic fields have the potential to generate electric fields in brain tissue that, if properly timed, m…
View article: EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment Open
View article: Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice
Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice Open
Sodium-glucose co-transporters (SGLTs) serve to reabsorb glucose in the kidney. Recently, these transporters, mainly SGLT2, have emerged as new therapeutic targets for patients with diabetes and kidney disease; by inhibiting glucose reabso…
View article: Table of Contents
Table of Contents Open
View article: Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants
Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants Open
Glycan-masking the vaccine antigen by mutating the undesired antigenic sites with an additional N -linked glycosylation motif can refocus B-cell responses to desired epitopes, without affecting the antigen’s overall-folded structure. This …
View article: Ureteral stone with hydronephrosis and urolithiasis alone are risk factors for acute kidney injury in patients with urinary tract infection
Ureteral stone with hydronephrosis and urolithiasis alone are risk factors for acute kidney injury in patients with urinary tract infection Open
View article: Glycan-masking spike antigen in NTD and RBD elicits broadly neutralizing antibodies against SARS-CoV-2 variants
Glycan-masking spike antigen in NTD and RBD elicits broadly neutralizing antibodies against SARS-CoV-2 variants Open
Glycan-masking the vaccine antigen by mutating the undesired antigenic sites with an additional N-linked glycosylation motif can refocus B-cell responses to desired/undesired epitopes, without affecting the antigen’s overall-folded structu…
View article: COVID-19 associated with concomitant mucormycosis and aspergillosis
COVID-19 associated with concomitant mucormycosis and aspergillosis Open
View article: Impact of Nutritional Assessment on the Clinical Outcomes of Patients with Non-albicans Candidemia: A Multicenter Study
Impact of Nutritional Assessment on the Clinical Outcomes of Patients with Non-albicans Candidemia: A Multicenter Study Open
Several studies have demonstrated that malnutrition is a negative prognostic factor for clinical outcomes. However, there is limited evidence for the effect of malnutrition on clinical outcomes in patients with candidemia. We investigated …
View article: COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay
COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay Open