Yan Zhou
YOU?
Author Swipe
View article: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines
A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines Open
Population-scale resources of genetic, molecular, and cellular information form the basis for understanding human genomes, charting the heritable basis of disease and tracing the effects of mutations. Pooled perturbation assays, probing th…
View article: Exogenous MeJA-induced chlorosis and senescence in flue-cured tobacco: concentration-dependent effects and transcriptomic analysis
Exogenous MeJA-induced chlorosis and senescence in flue-cured tobacco: concentration-dependent effects and transcriptomic analysis Open
View article: Bortezomib overcomes TRAIL resistance in Burkitt's lymphoma by enhancing apoptosis via reactive oxygen species‑mediated DR5 upregulation and MAPK pathway activation
Bortezomib overcomes TRAIL resistance in Burkitt's lymphoma by enhancing apoptosis via reactive oxygen species‑mediated DR5 upregulation and MAPK pathway activation Open
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills tumor cells and exerts minimal toxic effects on normal cells. However, resistance to TRAIL-induced apoptosis is a major obstacle in the clinical application …
View article: Bridging the gap: the role of 3D cell cultures in mimicking tumor microenvironment for enhanced drug testing accuracy
Bridging the gap: the role of 3D cell cultures in mimicking tumor microenvironment for enhanced drug testing accuracy Open
Cell culture is a crucial technology in life science research, particularly in cancer studies. The morphology and biological properties of tumor cells, along with the mechanisms of tumor development, are highly dependent on their culture c…
View article: Causal relationship between immune cells and osteoporosis based on genetic prediction: a bidirectional two-sample mediated Mendelian randomization analysis
Causal relationship between immune cells and osteoporosis based on genetic prediction: a bidirectional two-sample mediated Mendelian randomization analysis Open
Previous studies have explored the role of the immune system in osteoporosis. This Mendelian randomization (MR) study further evaluated the causal relationship between 731 immune cell phenotypes and osteoporosis, exploring the mediating ro…
View article: First Human Case of Diphyllobothriosis Due to <i>Dibothriocephalus Dendriticus</i> Infection - China, November 2023.
First Human Case of Diphyllobothriosis Due to <i>Dibothriocephalus Dendriticus</i> Infection - China, November 2023. Open
The increasing demand for fish products and raw foods poses a growing risk of diphyllobothriosis and potential economic losses. Attention should be paid to preventing D. dendriticus from becoming an emerging disease in China due to …
View article: Retarding human adipose-derived MSCs senescence and promoting tendon repair using cell sheet engineering with a histone methyltransferase inhibitor
Retarding human adipose-derived MSCs senescence and promoting tendon repair using cell sheet engineering with a histone methyltransferase inhibitor Open
Mesenchymal stem cell (MSC) holds immense potential as candidates for cell therapy in the treatment of tendon injuries due to their remarkable ability for multiple cell differentiation. However, the proliferative and differentiation capaci…
View article: Identification of quantitative trait loci and candidate genes associated with growth curve parameters in chinese wenshang barred chickens
Identification of quantitative trait loci and candidate genes associated with growth curve parameters in chinese wenshang barred chickens Open
The growth curve is a vital instrument for assessing and forecasting weight and developmental shifts in livestock and poultry, which reflects the changes of bodyweight traits with time and plays a key role in guiding breeding and productio…
View article: MAM‐STAT3‐Driven Mitochondrial Ca<sup>+2</sup> Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients
MAM‐STAT3‐Driven Mitochondrial Ca<sup>+2</sup> Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients Open
Individuals with homozygous laminA/C p.R527C mutations manifest a severe form of Mandibuloacral dysplasia‐(MAD) and exhibit overlapping progeroid symptoms, for which the underlying molecular pathology remains unknown. Herein, it is shown t…
View article: A genome-scale single cell CRISPRi map of<i>trans</i>gene regulation across human pluripotent stem cell lines
A genome-scale single cell CRISPRi map of<i>trans</i>gene regulation across human pluripotent stem cell lines Open
Population-scale resources of genetic, molecular, and cellular information form the basis for understanding human genomes, charting the heritable basis of disease, and tracing the effects of mutations. Pooled perturbation assays applied to…
View article: Elucidation of the genetic determination of body weight and size in Chinese local chicken breeds by large-scale genomic analyses
Elucidation of the genetic determination of body weight and size in Chinese local chicken breeds by large-scale genomic analyses Open
Background Body weight and size are important economic traits in chickens. While many growth-related quantitative trait loci (QTLs) and candidate genes have been identified, further research is needed to confirm and characterize these find…
View article: Identification of a DNA damage repair-related LncRNA signature for predicting the prognosis and immunotherapy response of hepatocellular carcinoma
Identification of a DNA damage repair-related LncRNA signature for predicting the prognosis and immunotherapy response of hepatocellular carcinoma Open
View article: Morphology-based deep learning enables accurate detection of senescence in mesenchymal stem cell cultures
Morphology-based deep learning enables accurate detection of senescence in mesenchymal stem cell cultures Open
View article: As Potential Interleukin-1β Inhibitors, Monoterpene-Coumarins from the Roots and Rhizomes of Notopterygium Incisum
As Potential Interleukin-1β Inhibitors, Monoterpene-Coumarins from the Roots and Rhizomes of Notopterygium Incisum Open
View article: Advances in the Research on the Characteristics and Applications of Bacillus tequilensis
Advances in the Research on the Characteristics and Applications of Bacillus tequilensis Open
View article: A common spectrum underlying brain disorders across lifespan revealed by deep learning on brain networks
A common spectrum underlying brain disorders across lifespan revealed by deep learning on brain networks Open
Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key neuroimaging evidence remains unrevealed for elucidating such commonness and the relationships among these…
View article: DNA Nanotechnology-Empowered Fluorescence Imaging of APE1 Activity
DNA Nanotechnology-Empowered Fluorescence Imaging of APE1 Activity Open
Apurinic/apyrimidinic endonuclease 1 (APE1), also known as redox factor-1 (Ref-1), is a multifunctional protein that exists widely in living organisms. It can specifically recognize and cleave the DNA in apurinic/apyrimidinic (AP) sites in…
View article: DNA Nanotechnology-Empowered Fluorescence Imaging of APE1 Activity
DNA Nanotechnology-Empowered Fluorescence Imaging of APE1 Activity Open
Apurinic/apyrimidinic endonuclease 1 (APE1), also known as redox factor-1 (Ref-1), is a multifunctional protein which is widely existing in living organisms. It can specifically recognize and cleave the DNA in apurinic/apyrimidinic (AP) si…
View article: Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells
Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells Open
Perturbing expression is a powerful way to understand the role of individual genes, but can be challenging in important models. CRISPR-Cas screens in human induced pluripotent stem cells (iPSCs) are of limited efficiency due to DNA break-i…
View article: Investigating the genetic determination of clutch traits in Chinese local chicken breed
Investigating the genetic determination of clutch traits in Chinese local chicken breed Open
Background:Egg-laying rate is the trait with the highest economic weight in breeding programs for laying hens. Egg-laying rate is associated with a clutch, which is defined as consecutive days of oviposition. Clutch traits can be used to d…
View article: Additional file 3 of Genome-wide identification of the longan R2R3-MYB gene family and its role in primary and lateral root
Additional file 3 of Genome-wide identification of the longan R2R3-MYB gene family and its role in primary and lateral root Open
Additional file 3.
View article: Additional file 2 of Genome-wide identification of the longan R2R3-MYB gene family and its role in primary and lateral root
Additional file 2 of Genome-wide identification of the longan R2R3-MYB gene family and its role in primary and lateral root Open
Additional file 2: Supplemental Table 1. Primers used in this study.
View article: Stem Cell-Based Therapeutic Strategies for Premature Ovarian Insufficiency and Infertility: A Focus on Aging
Stem Cell-Based Therapeutic Strategies for Premature Ovarian Insufficiency and Infertility: A Focus on Aging Open
Reproductive aging is on the rise globally and inseparable from the entire aging process. An extreme form of reproductive aging is premature ovarian insufficiency (POI), which to date has mostly been of idiopathic etiology, thus hampering …
View article: MAM-STAT3-induced upregulation of mitochondrial Ca<sup>+2</sup> causes immunosenescence in patients with type A mandibuloacral dysplasia
MAM-STAT3-induced upregulation of mitochondrial Ca<sup>+2</sup> causes immunosenescence in patients with type A mandibuloacral dysplasia Open
Homozygous lamina/c p.R527C mutations result in severe mandibuloacral dysplasia (MAD) and progeroid syndrome, but the underlying molecular pathology remains unknown. Here, we report on three patients with MAD, all displaying severe systemi…
View article: Massively targeted evaluation of therapeutic CRISPR off-targets in cells
Massively targeted evaluation of therapeutic CRISPR off-targets in cells Open
View article: Massively Targeted Evaluation of Therapeutic CRISPR Off-Targets in Cells
Massively Targeted Evaluation of Therapeutic CRISPR Off-Targets in Cells Open
Sensitive and high-throughput evaluation of CRISPR RNA-guided nucleases (RGNs) off-targets (OTs) in cells are essential for safety assessment and advancing RGN-based gene therapies. Here we apply a modified library approach, SURRO-seq, for…
View article: De novo transcriptome assembly reveals characteristics of flower sex determination of Excoecaria agallocha
De novo transcriptome assembly reveals characteristics of flower sex determination of Excoecaria agallocha Open
Figure S1. The length distribution of transcripts (a) and unigenes (b). The inserts show the frequency distribution of the transcript length (a) and of the unigene length (b). Figure S2. Pearson correlation between samples. Figure S3. The …
View article: Additional file 2 of Response of anthocyanin biosynthesis to light by strand-specific transcriptome and miRNA analysis in Capsicum annuum
Additional file 2 of Response of anthocyanin biosynthesis to light by strand-specific transcriptome and miRNA analysis in Capsicum annuum Open
Additional file 2: Table S2. Quality evaluation of sample sequencing output data for small RNA libraries.
View article: De novo transcriptome assembly reveals characteristics of flower sex determination of Excoecaria agallocha
De novo transcriptome assembly reveals characteristics of flower sex determination of Excoecaria agallocha Open
Figure S1. The length distribution of transcripts (a) and unigenes (b). The inserts show the frequency distribution of the transcript length (a) and of the unigene length (b). Figure S2. Pearson correlation between samples. Figure S3. The …
View article: Additional file 11 of Response of anthocyanin biosynthesis to light by strand-specific transcriptome and miRNA analysis in Capsicum annuum
Additional file 11 of Response of anthocyanin biosynthesis to light by strand-specific transcriptome and miRNA analysis in Capsicum annuum Open
Additional file 11: Table S11. The detailed information between DE lncRNA and its targeted mRNA.