Yida Jiang
YOU?
Author Swipe
View article: Endothelial HIF2α suppresses retinal angiogenesis in neonatal mice by upregulating NOTCH signaling
Endothelial HIF2α suppresses retinal angiogenesis in neonatal mice by upregulating NOTCH signaling Open
Prolyl hydroxylase domain (PHD) proteins are oxygen sensors that use intracellular oxygen as a substrate to hydroxylate hypoxia-inducible factor (HIF) α proteins, routing them for polyubiquitylation and proteasomal degradation. Typically, …
View article: Tailless and hypoxia inducible factor-2α cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice
Tailless and hypoxia inducible factor-2α cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice Open
Tailless (TLX, an orphan nuclear receptor) and hypoxia inducible factor-2α (HIF2α) are both essential for retinal astrocyte and vascular development. Tlx−/− mutation and astrocyte specific Hif2α disruption in Hif2αf/f/GFAPCre mice are know…
View article: Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis
Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis Open
Our data indicate that the NRF2-HO1 axis protects TJ integrity and RPE barrier functions by driving heme degradation.
View article: Oxygen-sensing mechanisms in development and tissue repair
Oxygen-sensing mechanisms in development and tissue repair Open
Under normoxia, hypoxia inducible factor (HIF) α subunits are hydroxylated by PHDs (prolyl hydroxylase domain proteins) and subsequently undergo polyubiquitylation and degradation. Normal embryogenesis occurs under hypoxia, which suppresse…
View article: Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK
Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK Open
Significance Caveolin-1 (Cav-1) is a major structural protein of caveolae found in cell membranes and is critical for numerous cellular functions. However, it remains unclear whether Cav-1 plays a role in ocular neovascularization, a major…
View article: Regulatory pathways dependent on the RseP protease in Pseudomonas aeruginosa
Regulatory pathways dependent on the RseP protease in Pseudomonas aeruginosa Open
The opportunistic pathogen P. aeruginosa is responsible for a wide range of infections and is wide spread in many soils and human surroundings. In order to survive, the bacteria overcome limited iron bio-availability by releasing iron-chel…
View article: PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently Open
Anti-VEGF-A therapy has proven to be effective for many neovascular diseases. However, drug resistance to anti-VEGF-A treatment can develop. Also, not all patients with neovascular diseases are responsive to anti-VEGF-A treatment. The mech…