Yi‐Da Tang
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View article: Deep learning-based phenotyping and assessment of treatment responses in heart failure with preserved ejection fraction
Deep learning-based phenotyping and assessment of treatment responses in heart failure with preserved ejection fraction Open
Background Heart failure with preserved ejection fraction (HFpEF) accounts for over half of heart failure cases, yet effective treatments remain limited due to the syndrome’s clinical heterogeneity. Purpose This study aimed to identify dis…
View article: Gibberellin Disrupts Hormonal Homeostasis and Anther Integrity to Trigger Sex Reversal in Spinach
Gibberellin Disrupts Hormonal Homeostasis and Anther Integrity to Trigger Sex Reversal in Spinach Open
Spinach is a dioecious vegetable and an excellent model for investigating plant sex differentiation. Exogenous gibberellin treatment induced sepal hypoplasia and sex reversal, converting 42% of stamens into pistils in male plants. Transcri…
View article: A Novel Morphological Classification to Guide Transcatheter Mitral Valve Edge-to-Edge Repair for Commissural Mitral Regurgitation
A Novel Morphological Classification to Guide Transcatheter Mitral Valve Edge-to-Edge Repair for Commissural Mitral Regurgitation Open
Our results highlight the value of the morphological classification system in enhancing TEER for commissural DMR. By addressing specific anatomical challenges, this system promotes tailored interventions that optimize procedural success an…
View article: Systematic Evaluation of Somatic Contamination in Germline Genomes
Systematic Evaluation of Somatic Contamination in Germline Genomes Open
Large-scale genomic initiatives like the UK Biobank (UKB) have revolutionized our understanding of human disease. These studies typically assume that blood-derived DNA faithfully reflects an individual’s germline genome. However, this assu…
View article: Attitudes, Perceptions, and Factors Influencing the Adoption of AI in Health Care Among Medical Staff: Nationwide Cross-Sectional Survey Study
Attitudes, Perceptions, and Factors Influencing the Adoption of AI in Health Care Among Medical Staff: Nationwide Cross-Sectional Survey Study Open
Background Artificial intelligence (AI) has demonstrated transformative potential in the health care field; yet, its clinical adoption faces challenges such as inaccuracy, bias, and data privacy concerns. As the primary operators of AI sys…
View article: Safety and Efficacy of Tafamidis in Chinese Patients with Transthyretin Amyloid Cardiomyopathy
Safety and Efficacy of Tafamidis in Chinese Patients with Transthyretin Amyloid Cardiomyopathy Open
NCT04814186.
View article: Combined assessment of stress hyperglycemia ratio and glycemic variability to predict all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases across different glucose metabolic states: an observational cohort study with machine learning
Combined assessment of stress hyperglycemia ratio and glycemic variability to predict all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases across different glucose metabolic states: an observational cohort study with machine learning Open
Combined SHR and GV assessment serves as a critical prognostic tool for ASCVD mortality, providing enhanced predictive accuracy compared to individual metrics, particularly in NGR and Pre-DM patients. This integrated approach could inform …
View article: Influence and molecular mechanism of cinnamaldehyde against ventricular arrhythmia via the TAK1-p38MAPK-NLRP3 pathway
Influence and molecular mechanism of cinnamaldehyde against ventricular arrhythmia via the TAK1-p38MAPK-NLRP3 pathway Open
Based on the transforming growth factor β-activated kinase 1 (TAK1)-p38 mitogen-activated protein kinase (p38MAPK)-nucleotide-binding oligo-like receptor protein 3 (NLRP3) signalling pathway, the protective effect and mechanism of isoprote…
View article: Safe RLHF-V: Safe Reinforcement Learning from Multi-modal Human Feedback
Safe RLHF-V: Safe Reinforcement Learning from Multi-modal Human Feedback Open
Multimodal large language models (MLLMs) are essential for building general-purpose AI assistants; however, they pose increasing safety risks. How can we ensure safety alignment of MLLMs to prevent undesired behaviors? Going further, it is…
View article: Prognostic implications of increased and final quantitative flow ratios in patients treated with drug-coated balloons physiological evaluation after DCB in de novo lesions
Prognostic implications of increased and final quantitative flow ratios in patients treated with drug-coated balloons physiological evaluation after DCB in de novo lesions Open
After DCB in de novo lesions of small coronary disease, both post-PCI QFR and ΔQFR showed similar prognostic implications in MACE.
View article: Identification of Digital Twins to Guide Interpretable AI for Diagnosis and Prognosis in Heart Failure
Identification of Digital Twins to Guide Interpretable AI for Diagnosis and Prognosis in Heart Failure Open
Summary Background Heart failure (HF) is a highly heterogeneous and complex condition. Although patient care generates vast amounts of clinical data, robust methods to synthesize available data for individualized management are lacking. Me…
View article: Integrated untargeted/targeted metabolomics identifies a putative oxylipin signature in patients with atrial fibrillation and coronary heart disease
Integrated untargeted/targeted metabolomics identifies a putative oxylipin signature in patients with atrial fibrillation and coronary heart disease Open
Background and Objective Atrial fibrillation (AF) and coronary heart disease (CHD) are closely related to metabolic dysregulation. However, the metabolic characteristics of AF patients with concomitant CHD remain unclear. The aims of this …
View article: Revolutionizing Health Care: The Transformative Impact of Large Language Models in Medicine
Revolutionizing Health Care: The Transformative Impact of Large Language Models in Medicine Open
Large language models (LLMs) are rapidly advancing medical artificial intelligence, offering revolutionary changes in health care. These models excel in natural language processing (NLP), enhancing clinical support, diagnosis, treatment, a…
View article: Association between Frailty, Metabolic Syndrome, and Mortality across young population and different genders: findings from National Health and Nutrition Examination Surveys (NHANES)
Association between Frailty, Metabolic Syndrome, and Mortality across young population and different genders: findings from National Health and Nutrition Examination Surveys (NHANES) Open
Background: This study aims to elucidate the relationship between frailty score (FS), metabolic syndrome (MS), and their combined impact on mortality among young population and different genders using the National Health and Nutrition Exam…
View article: Real-World Performance of Large Language Models in Emergency Department Chest Pain Triage and the development of MediGuide-14B
Real-World Performance of Large Language Models in Emergency Department Chest Pain Triage and the development of MediGuide-14B Open
This study evaluated the performance of large language models (LLMs) in diagnosing acute coronary syndrome (ACS) in emergency chest pain triage. We compared two Chinese LLMs, ‘Tongyi Qianwen’ and ‘Lingyi Zhihui,’ with MediGuide-14B and hum…
View article: Diagnostic value of galectin-3, fractalkine, IL-6, miR-21 and cardiac troponin I in human ischemic cardiomyopathy
Diagnostic value of galectin-3, fractalkine, IL-6, miR-21 and cardiac troponin I in human ischemic cardiomyopathy Open
Our study revealed that up-regulated serum Gal-3, FKN, IL-6, miR-21, and cTnI levels were closely related to the progression of ICM. This association implies that these biomarkers have diagnostic potential, offering a promising avenue for …
View article: Efficacy and Safety of Ongericimab in Chinese Patients With Primary Hypercholesterolemia and Mixed Dyslipidemia
Efficacy and Safety of Ongericimab in Chinese Patients With Primary Hypercholesterolemia and Mixed Dyslipidemia Open
Background A phase 3 trial was conducted to evaluate the efficacy and safety of ongericimab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9, as an add‐on treatment to optimized lipid‐lowering therapy in C…
View article: Permanent pacemaker reduction using temporary-permanent pacemaker as a 1-month bridge after transcatheter aortic valve replacement: a prospective, multicentre, single-arm, observational study
Permanent pacemaker reduction using temporary-permanent pacemaker as a 1-month bridge after transcatheter aortic valve replacement: a prospective, multicentre, single-arm, observational study Open
Beijing Science and Technology Plan 2022 from Beijing Municipal Science & Technology Commission.
View article: Revolutionizing Health Care: The Transformative Impact of Large Language Models in Medicine (Preprint)
Revolutionizing Health Care: The Transformative Impact of Large Language Models in Medicine (Preprint) Open
UNSTRUCTURED Large language models (LLMs) are rapidly advancing medical artificial intelligence, offering revolutionary changes in health care. These models excel in natural language processing (NLP), enhancing clinical support, diagnosis…
View article: Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure
Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure Open
BACKGROUND: Heart failure (HF), which is the terminal stage of many cardiovascular diseases, is associated with low survival rates and a severe financial burden. The mechanisms, especially the molecular mechanism combined with new theories…
View article: Safety and efficacy of the DragonFly system for transcatheter valve repair of degenerative mitral regurgitation: one-year results of the DRAGONFLY-DMR trial
Safety and efficacy of the DragonFly system for transcatheter valve repair of degenerative mitral regurgitation: one-year results of the DRAGONFLY-DMR trial Open
The DRAGONFLY-DMR trial contributes to increasing evidence supporting the safety and efficacy of TEER therapy, specifically the DragonFly system, for treating patients with chronic symptomatic DMR 3+ to 4+ at prohibitive surgical risk.
View article: Diagnostic Performance of Noninvasive Coronary Computed Tomography Angiography-Derived FFR for Coronary Lesion-Specific Ischemia Based on Deep Learning Analysis
Diagnostic Performance of Noninvasive Coronary Computed Tomography Angiography-Derived FFR for Coronary Lesion-Specific Ischemia Based on Deep Learning Analysis Open
Background: The noninvasive computed tomography angiography–derived fractional flow reserve (CT-FFR) can be used to diagnose coronary ischemia. With advancements in associated software, the diagnostic capability of CT-FFR may have evolved.…
View article: Association of coffee consumption with atherosclerotic cardiovascular disease and all-cause mortality in adults with familial hypercholesterolemia: Results from National Health and Nutrition Examination Survey (NHANES)
Association of coffee consumption with atherosclerotic cardiovascular disease and all-cause mortality in adults with familial hypercholesterolemia: Results from National Health and Nutrition Examination Survey (NHANES) Open
Familial hypercholesterolemia (FH) is a common inherited metabolic disorder with an elevated risk of atherosclerotic cardiovascular disease (ASCVD). The effects of coffee on FH individuals remain unclear. The aim of this study is to examin…