Yidan Zhang
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View article: X-ray-driven nanomotor with enhanced penetration and retention for carbon monoxide-amplified radioimmunotherapy of advanced colorectal cancer
X-ray-driven nanomotor with enhanced penetration and retention for carbon monoxide-amplified radioimmunotherapy of advanced colorectal cancer Open
View article: Diagnostic utility of contrast-enhanced ultrasound parameters in classifying lupus nephritis
Diagnostic utility of contrast-enhanced ultrasound parameters in classifying lupus nephritis Open
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), with renal biopsy as the diagnostic gold standard. However, biopsy is invasive. This study aims to evaluate the potential of contrast-enhanced …
View article: Enhancing Volatile Fatty Acid Accumulation in Seaweed-Arrested Anaerobic Digestion via a Two-Tier Framework of Engineering Diagnostics and Microbial Surveillance
Enhancing Volatile Fatty Acid Accumulation in Seaweed-Arrested Anaerobic Digestion via a Two-Tier Framework of Engineering Diagnostics and Microbial Surveillance Open
This study presents a two-tier framework for brown seaweed–arrested anaerobic digestion (SW-AAD) by coupling engineering diagnostics (tier-1) with microbial surveillance (tier-2) to transform conventional digesters into volatile fatty acid…
View article: Bilateral superior oblique suture extension in pediatric A-pattern esotropia
Bilateral superior oblique suture extension in pediatric A-pattern esotropia Open
Background: A-pattern esotropia is defined as an increase of more than 10 prism diopters (PD) divergence in down-gaze than in up-gaze. The long-term outcomes of bilateral superior oblique tendon suture extension (SOSE), a hardware-free tec…
View article: Surgical treatment and levator muscle protein analysis of congenital ptosis in craniosynostosis: A case-control study
Surgical treatment and levator muscle protein analysis of congenital ptosis in craniosynostosis: A case-control study Open
In this study, we compared the differences between children with craniosynostosis and those diagnosed with severe congenital ptosis who received conjoint fascial sheath suspension surgery. This study included 39 children, 19 craniosynostos…
View article: Exploring NDVI Responses to Regional Climate Change by Leveraging Interpretable Machine Learning: A Case Study of Chengdu City in Southwest China
Exploring NDVI Responses to Regional Climate Change by Leveraging Interpretable Machine Learning: A Case Study of Chengdu City in Southwest China Open
Regional extreme climate change remains a major environmental issue of global concern. However, in the context of the joint effects of urban expansion and the urban ecological environment, the responses of the normalized difference vegetat…
View article: Adverse Effects of Glyphosate and Microcystin-LR on Fish Health: Evidence from Structural and Functional Impairments in Zebrafish Gills
Adverse Effects of Glyphosate and Microcystin-LR on Fish Health: Evidence from Structural and Functional Impairments in Zebrafish Gills Open
Glyphosate (GLY) and microcystin-LR (MC-LR) frequently co-occur in natural water bodies. In this study, a subacute exposure test was conducted on zebrafish treated with 3.5 mg/L GLY and 35 μg/L MC-LR, individually and in combination, for 2…
View article: Edaravone plus compound cerebroside in elderly patients with carotid plaque cerebral infarction: Efficacy and prognosis
Edaravone plus compound cerebroside in elderly patients with carotid plaque cerebral infarction: Efficacy and prognosis Open
Edaravone, dextran and compound cerebroside combination therapy has a significant clinical effect on elderly CPMCI patients without reperfusion therapy, which can improve their functional independence, neurological function, activities of …
View article: An explainable radiomics-based machine learning model for preoperative differentiation of parathyroid carcinoma and atypical tumors on ultrasound: a retrospective diagnostic study
An explainable radiomics-based machine learning model for preoperative differentiation of parathyroid carcinoma and atypical tumors on ultrasound: a retrospective diagnostic study Open
Background Parathyroid carcinoma (PC) and atypical parathyroid tumors (APT), constituting rare endocrine malignancies, demonstrate overlapping clinical-radiological presentations with benign adenomas. This study aimed to investigate the pr…
View article: T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma
T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma Open
Background The clinical guideline classifies T‐LBL and T‐ALL jointly, differentiating them merely by the bone marrow blast cell proportion. However, their distinct clinical manifestations, genetic profiles, and specific pathogenic requirem…
View article: Comparative Gastrointestinal Digestion Dynamics of Air-Dried and Freeze-Dried Yak Jerky: Insights from a Dynamic In Vitro Human Stomach–Intestine (DHSI-IV) System
Comparative Gastrointestinal Digestion Dynamics of Air-Dried and Freeze-Dried Yak Jerky: Insights from a Dynamic In Vitro Human Stomach–Intestine (DHSI-IV) System Open
Yak meat jerky, a traditional high-protein food commonly consumed in high-altitude regions, is often produced via air-drying, which may adversely affect its nutritional quality and digestibility. This study systematically compared the gast…
View article: Further analysis and suggestions on “LRRC2: A new prognostic marker in breast invasive carcinoma”
Further analysis and suggestions on “LRRC2: A new prognostic marker in breast invasive carcinoma” Open
View article: Lower phase angle as a marker for poor prognosis in patients with chronic kidney disease: a cohort study
Lower phase angle as a marker for poor prognosis in patients with chronic kidney disease: a cohort study Open
Objective Phase angle (PhA) obtained through bioimpedance analysis has been linked to mortality and malnutrition in dialysis patients. However, it remains unclear whether PhA is associated with renal prognosis in non-dialysis CKD patients.…
View article: Impact of the ENPP1 mutation on bone mineralization and ectopic calcification: evidence from in vitro and in vivo models
Impact of the ENPP1 mutation on bone mineralization and ectopic calcification: evidence from in vitro and in vivo models Open
Background Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 ( ENPP1 ) plays a key role in mineralization processes, and mutations in this gene are associated with various severe diseases. Clinical case reports have implicated the ENPP1 Y…
View article: 466 | CAR‐T THERAPY WITH OX40 SIGNALING DRIVES CLONAL EXPANSION OF CD4+ T CELLS AND OVERCOMES IMMUNOSUPPRESSIVE MICROENVIRONMENT IN B‐CELL LYMPHOMA: A PHASE I TRIAL
466 | CAR‐T THERAPY WITH OX40 SIGNALING DRIVES CLONAL EXPANSION OF CD4+ T CELLS AND OVERCOMES IMMUNOSUPPRESSIVE MICROENVIRONMENT IN B‐CELL LYMPHOMA: A PHASE I TRIAL Open
View article: No sex difference in the association of pre-stroke physical activity with functional independence after ischemic stroke
No sex difference in the association of pre-stroke physical activity with functional independence after ischemic stroke Open
Whether physical activity is associated with functional outcomes from ischemic stroke remains poorly understood. We aimed to explore the association of pre-stroke physical activity and functional outcomes in patients with acute ischemic st…
View article: High Conversion Efficiency, High Beam Quality, High Peak Power 520 ps, 100 Hz, 2 mJ Tunable Blue All-Solid-State Laser
High Conversion Efficiency, High Beam Quality, High Peak Power 520 ps, 100 Hz, 2 mJ Tunable Blue All-Solid-State Laser Open
This study demonstrates a wavelength-tunable blue solid-state laser system based on a hundred-picosecond microchip laser. By utilizing a 355 nm laser to pump a beta-barium borate optical parametric oscillator (BBO-OPO), the system achieves…
View article: A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors
A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors Open
Objective Parathyroid carcinoma (PC) and atypical parathyroid tumor (APT) are rare malignant parathyroid disorders with varying degrees of recurrence risk. The aim of this study was to determine an effective model for discriminating PC/APT…
View article: Inhalation aromatherapy for the treatment of comorbid insomnia: a systematic review and meta-analysis
Inhalation aromatherapy for the treatment of comorbid insomnia: a systematic review and meta-analysis Open
Objective Meta-analysis can pool multiple studies to explore a particular area in depth, therefore this method was used to explore the clinical efficacy of inhalation aromatherapy for the treatment of comorbid insomnia and provide an empir…
View article: Spatial Heterogeneity of <scp>PD</scp>‐<scp>L1</scp> Expression as a Biomarker for Third‐Generation <scp>EGFR</scp>‐<scp>TKI</scp> Response in Advanced <scp>EGFR</scp>‐Mutant <scp>NSCLC</scp>
Spatial Heterogeneity of <span>PD</span>‐<span>L1</span> Expression as a Biomarker for Third‐Generation <span>EGFR</span>‐<span>TKI</span> Response in Advanced <span>EGFR</span>‐Mutant <span>NSCLC</span> Open
The association between the spatial heterogeneity of programmed cell death ligand 1 (PD‐L1) expression and the efficacy of third‐generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) in EGFR‐mutant non‐small ce…
View article: Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness
Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness Open
O3 exposure may reduce oxygen availability, prompting compensatory increases in red blood cells and hemoglobin, which exacerbate arterial stiffening. These findings provide new insights into the mechanisms underlying O3
View article: Greenspace in relation to childhood undernutrition: A cross-sectional study in 49 low- and middle-income countries
Greenspace in relation to childhood undernutrition: A cross-sectional study in 49 low- and middle-income countries Open
Evidence suggests greenspace may support child nutrition by increasing food availability, reducing environmental hazards, and enhancing microbial diversity, but evidence on the topic is scarce. We used Demographic and Health Surveys (DHS) …
View article: Cardiovascular health, genetic predisposition, and dementia risk among atherosclerotic cardiovascular disease patients
Cardiovascular health, genetic predisposition, and dementia risk among atherosclerotic cardiovascular disease patients Open
View article: Preparation and Application of Chinese Purple Pigment in Acrylic Resin Coatings for the Restoration of Cultural Relics
Preparation and Application of Chinese Purple Pigment in Acrylic Resin Coatings for the Restoration of Cultural Relics Open
View article: Melatonin Ameliorates Sepsis-Induced Myocardial Dysfunction by Promoting Autophagy Via Sirt1-Mediated Tfeb Deacetylation
Melatonin Ameliorates Sepsis-Induced Myocardial Dysfunction by Promoting Autophagy Via Sirt1-Mediated Tfeb Deacetylation Open
View article: Trend and Risk Factors of 12 Main Cancers Attributable to High Body Mass Index, with Forecasts to 2050: A Global Burden of Disease 2021 Analysis
Trend and Risk Factors of 12 Main Cancers Attributable to High Body Mass Index, with Forecasts to 2050: A Global Burden of Disease 2021 Analysis Open
View article: Preparation and application of Chinese purple pigment in acrylic resin coatings for the restoration of cultural relics
Preparation and application of Chinese purple pigment in acrylic resin coatings for the restoration of cultural relics Open
View article: Melatonin Ameliorates Sepsis-Induced Myocardial Dysfunction by Promoting Autophagy Via Sirt1-Mediated Tfeb Deacetylation
Melatonin Ameliorates Sepsis-Induced Myocardial Dysfunction by Promoting Autophagy Via Sirt1-Mediated Tfeb Deacetylation Open
View article: Osimertinib for <scp>EGFR</scp>‐Mutant <scp>NSCLC</scp> Patients With Acquired <scp>T790M</scp> and <scp>EGFR</scp> Amplification After First‐Generation <scp>EGFR</scp>‐<scp>TKI</scp> Resistance
Osimertinib for <span>EGFR</span>‐Mutant <span>NSCLC</span> Patients With Acquired <span>T790M</span> and <span>EGFR</span> Amplification After First‐Generation <span>EGFR</span>‐<span>TKI</span> Resistance Open
Third‐generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) is the standard therapy for patients harboring T790M after first‐generation EGFR‐TKI resistance. However, the impact of acquired EGFR amplification on t…
View article: Exploring Evaluation Methods in Project-Based Teaching of Elementary School Fine Art
Exploring Evaluation Methods in Project-Based Teaching of Elementary School Fine Art Open
Proper evaluation can enhance teaching efficiency and help students improve their overall competencies. This study based on practical experience, proposes feasible methods and strategies for designing and implementing evaluations in projec…