Yifan Jian
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View article: Quantitative Measurements of Stromal and Epithelial Riboflavin With a Novel Transepithelial High-Concentration Riboflavin Soak-and-Rinse Protocol
Quantitative Measurements of Stromal and Epithelial Riboflavin With a Novel Transepithelial High-Concentration Riboflavin Soak-and-Rinse Protocol Open
The novel transepithelial riboflavin soak-and-rinse protocol may potentially enhance the efficacy of transepithelial CXL by reducing epithelial consumption of ultraviolet light and oxygen and increasing the stromal CXL reaction.
View article: Convolutional neural network-based differentiation of intraocular inflammatory cells with ultrahigh-resolution OCT
Convolutional neural network-based differentiation of intraocular inflammatory cells with ultrahigh-resolution OCT Open
The differential diagnosis of uveitis is broad and often challenging. A key indicator of intraocular inflammation is the presence of cells in the aqueous or vitreous humor. We developed a lightweight convolutional neural network (CNN) mode…
View article: Quantitative measurement using panretinal optical coherence tomography with three-dimensional curve distortion correction
Quantitative measurement using panretinal optical coherence tomography with three-dimensional curve distortion correction Open
Panretinal optical coherence tomography (PanOCT) enables rapid, widefield retinal imaging up to 140°, visualizing peripheral regions including the ora serrata. However, raw B-scan images exhibit curvature distortion, limiting quantitative …
View article: Non-mydriatic handheld optical coherence tomography for panretinal imaging
Non-mydriatic handheld optical coherence tomography for panretinal imaging Open
We present a handheld, non-mydriatic optical coherence tomography (OCT) system engineered for panretinal imaging across both pediatric and adult patients. The prototype achieves a 140° visual angle, enabling detailed visualization from the…
View article: OCT-Derived Quantitative Measurement of Extent of Vascularization (“Zone”) in Retinopathy of Prematurity
OCT-Derived Quantitative Measurement of Extent of Vascularization (“Zone”) in Retinopathy of Prematurity Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: High-resolution multimodal visible light optical coherence tomography and scanning laser ophthalmoscopy for <i>in vivo</i> neuronal and vascular retinal imaging in mice
High-resolution multimodal visible light optical coherence tomography and scanning laser ophthalmoscopy for <i>in vivo</i> neuronal and vascular retinal imaging in mice Open
Microglial cells play a crucial role in retinal vascular and brain diseases through complex interactions with blood vessels and neurons. To image retinal structures, vasculature, and microglia, we developed a multimodal system integrating …
View article: Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT
Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT Open
View article: Single-Shot Ultra-Widefield Polarization-Diversity Optical Coherence Tomography for Assessing Retinal and Choroidal Pathologies
Single-Shot Ultra-Widefield Polarization-Diversity Optical Coherence Tomography for Assessing Retinal and Choroidal Pathologies Open
Background: Optical coherence tomography (OCT) is a leading ocular imaging modality, known for delivering high-resolution volumetric morphological images. However, conventional OCT systems are limited by their narrow field-of-view (FOV) an…
View article: Optical Assessment of Photoreceptor Function Over the Macula
Optical Assessment of Photoreceptor Function Over the Macula Open
This innovative advance can enable us to detect early photoreceptor abnormalities, as well as help to stage and monitor degenerative retinal diseases, potentially providing a surrogate visual function marker for retinal diseases and accele…
View article: Panretinal handheld OCT angiography for pediatric retinal imaging
Panretinal handheld OCT angiography for pediatric retinal imaging Open
Comprehensive visualization of retina morphology is essential in the diagnosis and management of retinal diseases in pediatric populations. Conventional imaging techniques often face challenges in effectively capturing the peripheral retin…
View article: Panretinal handheld OCT angiography for pediatric retinal imaging
Panretinal handheld OCT angiography for pediatric retinal imaging Open
Comprehensive visualization of retina morphology is essential in the diagnosis and management of retinal diseases in pediatric populations. Conventional imaging techniques often face challenges in effectively capturing the peripheral retin…
View article: Non-mydriatic ultra-widefield diffraction-limited retinal imaging
Non-mydriatic ultra-widefield diffraction-limited retinal imaging Open
We demonstrate a new non-mydriatic ultra-widefield optical coherence tomography retinal imaging system, designed with custom optics to improve the imaging field of view, lateral resolution, and patient comfort. The key motivation is to add…
View article: Panretinal handheld OCT angiography for pediatric retinal imaging
Panretinal handheld OCT angiography for pediatric retinal imaging Open
Comprehensive visualization of retina morphology is essential in the diagnosis and management of retinal diseases in pediatric populations. Conventional imaging techniques often face challenges in effectively capturing the peripheral retin…
View article: Real-time line-field optical coherence tomography for cellular resolution imaging of biological tissue
Real-time line-field optical coherence tomography for cellular resolution imaging of biological tissue Open
A real-time line-field optical coherence tomography (LF-OCT) system is demonstrated with image acquisition rates of up to 5000 B-frames or 2.5 million A-lines per second for 500 A-lines per B-frame. The system uses a high-speed low-cost ca…
View article: Implementation of optical coherence tomography in retinopathy of prematurity screening
Implementation of optical coherence tomography in retinopathy of prematurity screening Open
Purpose of review In this review, we explore the investigational applications of optical coherence tomography (OCT) in retinopathy of prematurity (ROP), the insights they have delivered thus far, and key milestones for its integration into…
View article: Segmental biomechanics of the normal and glaucomatous human aqueous outflow pathway
Segmental biomechanics of the normal and glaucomatous human aqueous outflow pathway Open
View article: Polarization-Diversity Optical Coherence Tomography Assessment of Choroidal Nevi
Polarization-Diversity Optical Coherence Tomography Assessment of Choroidal Nevi Open
PD-OCT allows objective assessment of choroidal nevi melanin content and distribution. In addition, melanin-specific contrast by PD-OCT enables clear nevus margin delineation and may improve serial growth surveillance. Further investigatio…
View article: DeepRank: Test Case Prioritization for Deep Neural Networks
DeepRank: Test Case Prioritization for Deep Neural Networks Open
Deep neural networks (DNNs) have been widely used in safety-critical fields such as autonomous driving and medical diagnosis.However, DNNs are easily disturbed to make wrong decisions, which may lead to loss of life or property.Therefore, …
View article: Panretinal Optical Coherence Tomography
Panretinal Optical Coherence Tomography Open
We introduce a new concept of panoramic retinal (panretinal) optical coherence tomography (OCT) imaging system with a 140° field of view (FOV). To achieve this unprecedented FOV, a contact imaging approach was used which enabled faster, mo…
View article: Developing an experimental-computational workflow to study the biomechanics of the human conventional aqueous outflow pathway
Developing an experimental-computational workflow to study the biomechanics of the human conventional aqueous outflow pathway Open
View article: Association of Optical Coherence Tomography–Measured Fibrovascular Ridge Thickness and Clinical Disease Stage in Retinopathy of Prematurity
Association of Optical Coherence Tomography–Measured Fibrovascular Ridge Thickness and Clinical Disease Stage in Retinopathy of Prematurity Open
Importance Accurate diagnosis of retinopathy of prematurity (ROP) is essential to provide timely treatment and reduce the risk of blindness. However, the components of an ROP examination are subjective and qualitative. Objective To evaluat…
View article: Corneal imaging with blue-light optical coherence microscopy
Corneal imaging with blue-light optical coherence microscopy Open
Corneal imaging is important for the diagnostic and therapeutic evaluation of many eye diseases. Optical coherence tomography (OCT) is extensively used in ocular imaging due to its non-invasive and high-resolution volumetric imaging charac…
View article: In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography
In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography Open
In vivo characterization of retinal morphology and vasculature plexus of multiple species using SS-OCT and SS-OCTA imaging can increase the pool of species available as models of human retinal diseases.
View article: Widefield Optical Coherence Tomography in Pediatric Retina: A Case Series of Intraoperative Applications Using a Prototype Handheld Device
Widefield Optical Coherence Tomography in Pediatric Retina: A Case Series of Intraoperative Applications Using a Prototype Handheld Device Open
Optical coherence tomography (OCT) has changed the standard of care for diagnosis and management of macular diseases in adults. Current commercially available OCT systems, including handheld OCT for pediatric use, have a relatively narrow …
View article: Ultrawide-field OCT for Retinoblastoma
Ultrawide-field OCT for Retinoblastoma Open
View article: Numerical calibration method for a multiple spectrometer-based OCT system
Numerical calibration method for a multiple spectrometer-based OCT system Open
The present paper introduces a numerical calibration method for the easy and practical implementation of multiple spectrometer-based spectral-domain optical coherence tomography (SD-OCT) systems. To address the limitations of the tradition…
View article: Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity
Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity Open
Recent advances in portable optical coherence tomography (OCT) and OCT angiography (OCTA) have resulted in wider fields of view (FOV) and shorter capture times, further expanding the potential clinical role of OCT technology in the diagnos…
View article: Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity
Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity Open
View article: 105° field of view non-contact handheld swept-source optical coherence tomography
105° field of view non-contact handheld swept-source optical coherence tomography Open
We demonstrate a handheld swept-source optical coherence tomography (OCT) system with a 400 kHz vertical-cavity surface-emitting laser (VCSEL) light source, a non-contact approach, and an unprecedented single shot 105° field of view (FOV).…
View article: Peripheral optical coherence tomography assisted by scleral depression in retinopathy of prematurity
Peripheral optical coherence tomography assisted by scleral depression in retinopathy of prematurity Open
Objective To determine whether handheld widefield optical coherence tomography (OCT) can be used to document retinopathy of prematurity (ROP) stage while using scleral depression to improve peripheral views. Design Prospective observationa…