Yifan Luo
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View article: Role of EMT in drug resistance of breast cancer: molecular mechanisms and therapeutic strategies
Role of EMT in drug resistance of breast cancer: molecular mechanisms and therapeutic strategies Open
Breast cancer, as the most common cancer in women, is a highly heterogeneous and complex tumor. One of the important reasons for the poor prognosis and high mortality of breast cancer patients is drug resistance. More and more evidence sho…
View article: Oxygen vacancy-rich engineering-optimized molybdenum trioxide microbelts for room-temperature ppb-level trimethylamine detection
Oxygen vacancy-rich engineering-optimized molybdenum trioxide microbelts for room-temperature ppb-level trimethylamine detection Open
Oxygen vacancies in metal oxides play a pivotal role in determining their electronic structure and interfacial redox dynamics. However, their sluggish kinetics and imbalanced adsorption/desorption hinder their performance. Here, we report …
View article: Decorated‐Induced Oxygen Vacancy Engineering for Ultra‐Low Concentration Nonanal Sensing: A Case Study of La‐Decorated Bi<sub>2</sub>O<sub>2</sub>CO<sub>3</sub>
Decorated‐Induced Oxygen Vacancy Engineering for Ultra‐Low Concentration Nonanal Sensing: A Case Study of La‐Decorated Bi<sub>2</sub>O<sub>2</sub>CO<sub>3</sub> Open
La‐decorated Bi 2 O 2 CO 3 (BCO‐La) microspheres are synthesized using a facile wet chemical strategy for sensing low‐concentration nonanal (C 9 H 18 O) at room temperature. These BCO‐La gas sensors are applied to evaluate agricultural pro…
View article: Urchin-like Na-doped zinc oxide nanoneedles for low-concentration and exclusive VOC detections
Urchin-like Na-doped zinc oxide nanoneedles for low-concentration and exclusive VOC detections Open
In the early-stage diagnosis of lung cancer, the low-concentration (< 5 ppm) volatile organic compounds (VOCs) are extensively identified to be the biomarkers for breath analysis. Herein, the urchin-like sodium (Na)-doped zinc oxide (ZnO) …
View article: Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties
Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties Open
Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, exploring factors potentially re…
View article: RNA 5-Methylcytosine regulators are associated with cell adhesion and predict prognosis of endometrial cancer
RNA 5-Methylcytosine regulators are associated with cell adhesion and predict prognosis of endometrial cancer Open
In conclusion, diverse m5C modification patterns display distinct cell adhesion properties in UCEC, which are correlated with prognosis and offer significant potential as prognostic markers for UCEC assessment. We developed a pr…
View article: Predicting vancomycin trough serum concentration in augmented renal clearance patients through an artificial neural network model
Predicting vancomycin trough serum concentration in augmented renal clearance patients through an artificial neural network model Open
Purpose: Artificial neural network (ANN) model has been developed in prediction of serum drug concentration. The aim of this study was verifying the accuracy of ANN model in predicting vancomycin trough serum concentration in ARC adult pat…
View article: Metal oxide semiconductor gas sensing materials for early lung cancer diagnosis
Metal oxide semiconductor gas sensing materials for early lung cancer diagnosis Open
The urgency of early lung cancer (LC) diagnosis and treatment has been more and more significant. Exhaled breath analysis using gas sensors is a promising way to find out if someone has LC due to its low-cost, non-invasive, and real-time m…
View article: A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy Open
Metastasis accounts for 90% of breast cancer deaths, where the lethality could be attributed to the poor drug accumulation at the metastatic loci. The tolerance to chemotherapy induced by breast cancer stem cells (BCSCs) and their particul…
View article: Role of cobalt in Co-ZnO nanoflower gas sensors for the detection of low concentration of VOCs
Role of cobalt in Co-ZnO nanoflower gas sensors for the detection of low concentration of VOCs Open
View article: Low concentration isopropanol gas sensing properties of Ag nanoparticles decorated In2O3 hollow spheres
Low concentration isopropanol gas sensing properties of Ag nanoparticles decorated In2O3 hollow spheres Open
In order to detect low concentrations of volatile organic compounds (VOCs) for the early diagnosis of lung cancer, sensors based on hollow spheres of In 2 O 3 were prepared through the soft template method. Ag nanoparticle decorated In 2 O…
View article: Augmented Renal Clearance: What Have We Known and What Will We Do?
Augmented Renal Clearance: What Have We Known and What Will We Do? Open
Augmented renal clearance (ARC) is a phenomenon of increased renal function in patients with risk factors. Sub-therapeutic drug concentrations and antibacterial exposure in ARC patients are the main reasons for clinical treatment failure. …
View article: Macrophage‐Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke
Macrophage‐Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke Open
Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective e…
View article: A Versatile Theranostic Platform for Colorectal Cancer Peritoneal Metastases: Real‐Time Tumor‐Tracking and Photothermal‐Enhanced Chemotherapy
A Versatile Theranostic Platform for Colorectal Cancer Peritoneal Metastases: Real‐Time Tumor‐Tracking and Photothermal‐Enhanced Chemotherapy Open
A versatile tumor‐targeting stimuli‐responsive theranostic platform for peritoneal metastases of colorectal cancer is proposed in this work for tumor tracking and photothermal‐enhanced chemotherapy. A quenched photosensitizer (“off” state)…
View article: Identification of in vitro-in vivo components of Caoguo using accelerated solvent extraction combined with gas chromatography-mass spectrometry integrated with network pharmacology on indigestion
Identification of in vitro-in vivo components of Caoguo using accelerated solvent extraction combined with gas chromatography-mass spectrometry integrated with network pharmacology on indigestion Open
Caoguo was first extracted by ASE and the volatile chemical components in vivo were first identified by GC-MS. Coupled with network pharmacology analysis, a network of component-target-pathway was constructed to reveal the possible …
View article: Correlation Analysis of Mood State and Symptom Clusters in Patients With Stage-Ⅳ Lung Cancer During Immunotherapy
Correlation Analysis of Mood State and Symptom Clusters in Patients With Stage-Ⅳ Lung Cancer During Immunotherapy Open
Purpose: To investigate the status of symptom clusters and mood states and analyze the correlation between them in patients with stage-IV lung cancer undergoing immunotherapy.Methods: Using a convenience sampling method, we selected 259 pa…
View article: Research on present situation of the hierarchical medical system in nursing work of emerging infectious diseases
Research on present situation of the hierarchical medical system in nursing work of emerging infectious diseases Open
Emerging infectious disease is characterized by sudden and rapid spread, and failure to curb its development in the first place would pose a serious threat to social stability and human health. The hierarchical medical system can realize r…
View article: Effect of Strain Rate on the Creep-Fatigue Damage of Ni-Base Superalloy at Elevated Temperatures
Effect of Strain Rate on the Creep-Fatigue Damage of Ni-Base Superalloy at Elevated Temperatures Open
Ni-based auperalloys are used in harsh high-temperature creep-fatigue environments. It has been reported that the lifetime is drastically decreased under creep-fatigue loads. However, the details of the mechanism of significant strength de…
View article: No longer endemic to Africa: Kribiodosis Kieffer, 1921 (Diptera, Chironomidae) new to Oriental China with a phylogeny and expanded adult generic diagnoses
No longer endemic to Africa: Kribiodosis Kieffer, 1921 (Diptera, Chironomidae) new to Oriental China with a phylogeny and expanded adult generic diagnoses Open
This dataset contains the digitized treatments in Plazi based on the original journal article Han, Wu, Liu, Jie, Luo, Yifan, Tang, Hongqu (2021): No longer endemic to Africa: Kribiodosis Kieffer, 1921 (Diptera, Chironomidae) new to Orienta…
View article: Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy Open
Significance Statement C3 glomerulopathy (C3G) is a rare, progressive kidney disease, characterized by alternative pathway hyperactivation and glomerular complement deposition. Animal models are valuable to explore modulators of C3G progre…
View article: Colon cancer-associated transcript-1 enhances glucose metabolism and colon cancer cell activity in a high-glucose environment in vitro and in vivo
Colon cancer-associated transcript-1 enhances glucose metabolism and colon cancer cell activity in a high-glucose environment in vitro and in vivo Open
CCAT-1 can enhance glucose metabolism and proliferation and migration of colon cancer cells by upregulating the expression of glycolysis enzymes, inhibiting apoptosis, activating the Akt/C-MYC pathway, and promoting EMT expression.
View article: Lactoferrin for the treatment of COVID‑19 (Review)
Lactoferrin for the treatment of COVID‑19 (Review) Open
The coronavirus disease 2019 (COVID-19) outbreak was caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical outcomes of elderly individuals and those with underlying diseases affected by COV…
View article: Ammonia Sensor Based on Vapor Phase Polymerized Polypyrrole
Ammonia Sensor Based on Vapor Phase Polymerized Polypyrrole Open
The detection of ammonia is an important issue for a lot of applications: leak detection in industry, agriculture, cooling systems, and medical diagnosis (breath biomarker for non-invasive diagnostic of renal disease). Among the possible s…
View article: miR‐373 inhibits autophagy and further promotes apoptosis of cholangiocarcinoma cells by targeting ULK1
miR‐373 inhibits autophagy and further promotes apoptosis of cholangiocarcinoma cells by targeting ULK1 Open
Intrahepatic cholangiocarcinoma is a malignant tumor originating from intrahepatic bile ducts. Surgical therapy, radiotherapy, and chemotherapy are taken to treat this disease, but it is prone to recurrence and metastasis, with poor progno…
View article: A systematic review and meta-analysis on the effects of metformin on survival outcomes and risk in women with cervical cancer
A systematic review and meta-analysis on the effects of metformin on survival outcomes and risk in women with cervical cancer Open
Objective: A systematic review and meta-analysis was conducted to quantitatively assess the effects of metformin on both the treatment and risk of cervical cancer in women. Materials and Methods: A search was conducted in a number of datab…
View article: Synthesis and acetone sensing properties of ZnFe<sub>2</sub>O<sub>4</sub>/rGO gas sensors
Synthesis and acetone sensing properties of ZnFe<sub>2</sub>O<sub>4</sub>/rGO gas sensors Open
Hollow spheres of pure ZnFe 2 O 4 and of composites of ZnFe 2 O 4 and reduced graphene oxide (rGO) with different rGO content were prepared via a simple solvothermal method followed by a high-temperature annealing process in an inert atmos…
View article: Intermittent vs. continuous vancomycin infusion for gram-positive infections: A systematic review and meta-analysis
Intermittent vs. continuous vancomycin infusion for gram-positive infections: A systematic review and meta-analysis Open
View article: Population pharmacokinetics of vancomycin in Chinese patients with augmented renal clearance
Population pharmacokinetics of vancomycin in Chinese patients with augmented renal clearance Open
In this study, a simple population pharmacokinetic (PPK) model of vancomycin in Chinese patients with ARC was established using a nonlinear mixed-effects model (NONMEM). The final PPK model could achieve a good predictive effect, which pro…
View article: Anti-hypertensive efficacy of amlodipine dosing during morning versus evening: A meta-analysis
Anti-hypertensive efficacy of amlodipine dosing during morning versus evening: A meta-analysis Open
A meta-analysis was performed to compare the antihypertensive efficacy of morning and evening dosing. Database of Pubmed, Embase, Cochrane, Web of Science CNKI, VIP, and Wanfang were searched up to December 2018. A total of 19 randomized c…
View article: Synthesis, Characterization and Acetone Sensing Performance of ZnFe2O4 Hollow Spheres/RGO Composites
Synthesis, Characterization and Acetone Sensing Performance of ZnFe2O4 Hollow Spheres/RGO Composites Open
ZnFe 2 O 4 hollow spheres and ZnFe 2 O 4 hollow spheres / RGO composites with different RGO contents were successfully synthesized using a one-pot solvothermal method. The morphology and microstructure of the as-prepared samples were chara…