Yongfeng Jin
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View article: The modern expansion of Dscam1 isoform diversity in Drosophila is linked to fitness and immunity
The modern expansion of Dscam1 isoform diversity in Drosophila is linked to fitness and immunity Open
Drosophila melanogaster Down Syndrome cell adhesion molecule 1 ( Dscam1 ) gene encodes 38,016 diverse cell surface receptor proteins via alternative splicing, which have both nervous and immune functions. However, it remains elusive why or…
View article: NMR-Solver: Automated Structure Elucidation via Large-Scale Spectral Matching and Physics-Guided Fragment Optimization
NMR-Solver: Automated Structure Elucidation via Large-Scale Spectral Matching and Physics-Guided Fragment Optimization Open
Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful and widely used tools for molecular structure elucidation in organic chemistry. However, the interpretation of NMR spectra to determine unknown molecular structures …
View article: Nonlinear Aerodynamic Responses of Flight Control Surfaces to Thrust Reverser Jet-Induced Flow Interference
Nonlinear Aerodynamic Responses of Flight Control Surfaces to Thrust Reverser Jet-Induced Flow Interference Open
Numerical simulations were performed using the RANS (Reynolds-averaged Navier–Stokes) approach to analyze the flow field around an aircraft during the landing rollout phase with thrust reversers deployed. The objective was to characterize …
View article: Impacts of Average Real Variability Parameters of Blood Pressure on Recovery Following Posterior Fixation Surgery for Thoracolumbar Vertebral Fractures
Impacts of Average Real Variability Parameters of Blood Pressure on Recovery Following Posterior Fixation Surgery for Thoracolumbar Vertebral Fractures Open
AIM: This study aimed to investigate the influence of average real variability (ARV) parameters of blood pressure on the recovery following posterior fixation surgery for thoracolumbar vertebral fractures. METHODS: A retrospective analysis…
View article: A Universal Strategy of Anti‐Tumor mRNA Vaccine by Harnessing “Off‐the‐Shelf” Immunity
A Universal Strategy of Anti‐Tumor mRNA Vaccine by Harnessing “Off‐the‐Shelf” Immunity Open
Personalized neoantigen cancer mRNA vaccines are promising candidates for precision medicine. However, the difficulty of identifying neoantigens heavily hinders their broad applicability. This study developed a universal strategy of anti‐t…
View article: Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy
Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy Open
Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. He…
View article: Single-cell RNA sequencing unveils dynamic transcriptional profiles during the process of donkey spermatogenesis and maturation
Single-cell RNA sequencing unveils dynamic transcriptional profiles during the process of donkey spermatogenesis and maturation Open
We performed single-cell RNA sequencing to analyze the cellular composition and spatial distribution of donkey testis and epididymis, thereby generating comprehensive transcriptional atlases at the single-cell resolution.
View article: RNA structure in alternative splicing regulation: from mechanism to therapy
RNA structure in alternative splicing regulation: from mechanism to therapy Open
Alternative splicing is a highly intricate process that plays a crucial role in post-transcriptional regulation and significantly expands the functional proteome of a limited number of coding genes in eukaryotes. Its regulation is multifac…
View article: 198P Detection of ERBB2 (HER2) amplification by next-generation sequencing (NGS) in patients (pts) with gastrointestinal (GI) cancer
198P Detection of ERBB2 (HER2) amplification by next-generation sequencing (NGS) in patients (pts) with gastrointestinal (GI) cancer Open
View article: Research progress of RNA modification and its association with human diseases
Research progress of RNA modification and its association with human diseases Open
Post-transcriptional chemical modifications are prevalent in various RNA molecules and play a profound role in biological functions, including the regulation of RNA splicing, translation, transport, localization, and stability. Recent adva…
View article: A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring
A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring Open
Drosophila melanogaster Down syndrome cell adhesion molecule 1 ( Dscam1 ) encodes 19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters. However, whether individual isoforms or exon clusters have spec…
View article: Structural basis for the self-recognition of sDSCAM in Chelicerata
Structural basis for the self-recognition of sDSCAM in Chelicerata Open
View article: <i>Cis</i> mutagenesis in vivo reveals extensive noncanonical functions of Dscam1 isoforms in neuronal wiring
<i>Cis</i> mutagenesis in vivo reveals extensive noncanonical functions of Dscam1 isoforms in neuronal wiring Open
Drosophila Down syndrome cell adhesion molecule 1 (Dscam1) encodes tens of thousands of cell recognition molecules via alternative splicing, which are required for neural function. A canonical self-avoidance model seems to provide a centra…
View article: Emerging Progress of RNA-Based Antitumor Therapeutics
Emerging Progress of RNA-Based Antitumor Therapeutics Open
RNA-based therapeutics (e.g., mRNAs, siRNAs, microRNAs, ASOs, and saRNAs) have considerable potential for tumor treatment. The development and optimization of RNA modifications and delivery systems enable the stable and efficient delivery …
View article: Structural Basis for the self-recognition of sDSCAM in Chelicerata
Structural Basis for the self-recognition of sDSCAM in Chelicerata Open
To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscams and vertebrate Pcdhs are implicated in determining synaptic specificity. Recently identified in Chelice…
View article: Trans-splicing facilitated by RNA pairing greatly expands sDscam isoform diversity but not homophilic binding specificity
Trans-splicing facilitated by RNA pairing greatly expands sDscam isoform diversity but not homophilic binding specificity Open
The Down syndrome cell adhesion molecule 1 ( Dscam1 ) gene can generate tens of thousands of isoforms via alternative splicing, which is essential for nervous and immune functions. Chelicerates generate approximately 50 to 100 shortened Ds…
View article: Recent advances in RNA structurome
Recent advances in RNA structurome Open
View article: Self-avoidance alone does not explain the function of Dscam1 in mushroom body axonal wiring
Self-avoidance alone does not explain the function of Dscam1 in mushroom body axonal wiring Open
View article: <i>Cis</i> mutagenesis <i>in vivo</i> reveals extensive noncanonical functions of Dscam1 isoforms in neuronal wiring
<i>Cis</i> mutagenesis <i>in vivo</i> reveals extensive noncanonical functions of Dscam1 isoforms in neuronal wiring Open
Drosophila Dscam1 encodes ten thousand of cell recognition molecules via alternative splicing, which is required for nervous function. However, the underlying mechanism has not fully understood. Here we revealed extensive noncanonical func…
View article: Self-avoidance alone does not explain the function of Dscam1 in mushroom body axonal wiring
Self-avoidance alone does not explain the function of Dscam1 in mushroom body axonal wiring Open
SUMMARY Alternative splicing of Drosophila Dscam1 into 38,016 isoforms provides neurons with a unique molecular code for self-recognition and self-avoidance. A canonical model suggests that homophilic binding of identical Dscam1 isoforms o…
View article: Hidden RNA pairings counteract the “first-come, first-served” splicing principle to drive stochastic choice in <i>Dscam1</i> splice variants
Hidden RNA pairings counteract the “first-come, first-served” splicing principle to drive stochastic choice in <i>Dscam1</i> splice variants Open
Drosophila melanogaster Dscam1 encodes 38,016 isoforms via mutually exclusive splicing; however, the regulatory mechanism behind this is not fully understood. Here, we found a set of hidden RNA secondary structures that balance the stochas…
View article: Supplementary Material for: Trends and Disparities in Stage-specific Incidence of Hepatocellular Carcinoma among US Adults, 2004-2019
Supplementary Material for: Trends and Disparities in Stage-specific Incidence of Hepatocellular Carcinoma among US Adults, 2004-2019 Open
Introduction: To determine the stage-specific incidence trend of hepatocellular carcinoma (HCC) among US adults. Methods: The age-adjusted incidence rate was extracted from Surveillance, Epidemiology, and End Results database for localized…
View article: Interleukin -1β Promotes Lung Adenocarcinoma Growth and Invasion Through Promoting Glycolysis via p38 Pathway
Interleukin -1β Promotes Lung Adenocarcinoma Growth and Invasion Through Promoting Glycolysis via p38 Pathway Open
Qi Tan,* Limin Duan,* Qi Huang,* Wenjuan Chen,* Zimo Yang, Jiangbin Chen, Yang Jin Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, H…
View article: Odontochilus putaoensis (Orchidaceae), a new record and key to the genus for China
Odontochilus putaoensis (Orchidaceae), a new record and key to the genus for China Open
Odontochilus putaoensis X.H.Jin, L
View article: B7-H3 Promotes Proliferation and Migration of Colorectal Cancer Cells by Regulating PYCR1 in the Proline Metabolism
B7-H3 Promotes Proliferation and Migration of Colorectal Cancer Cells by Regulating PYCR1 in the Proline Metabolism Open
Proline metabolism plays an essential role in tumor development; however, its underlying mechanism in CRC remains elusive. B7-H3, an immune checkpoint member of the B7 immunoregulatory family, is aberrantly overexpressed in a wide variety …
View article: Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring
Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring Open
View article: Complex RNA Secondary Structures Mediate Mutually Exclusive Splicing of Coleoptera Dscam1
Complex RNA Secondary Structures Mediate Mutually Exclusive Splicing of Coleoptera Dscam1 Open
Mutually exclusive splicing is an important mechanism for expanding protein diversity. An extreme example is the Down syndrome cell adhesion molecular ( Dscam1 ) gene of insects, containing four clusters of variable exons (exons 4, 6, 9, a…
View article: Supplementary Material for: New Reference Values for Thyroid Volume and a Comprehensive Assessment for Influencing Factors in Chinese Adults with Iodine Sufficiency
Supplementary Material for: New Reference Values for Thyroid Volume and a Comprehensive Assessment for Influencing Factors in Chinese Adults with Iodine Sufficiency Open
Objectives: The reference values for thyroid volume (Tvol) determined by ultrasound require supportive data of normal Tvol from local iodine-sufficient populations. This study aimed to explore new reference values for Tvol in…
View article: Synthesis of Ginsenoside Re-Based Carbon Dots Applied for Bioimaging and Effective Inhibition of Cancer Cells [Corrigendum]
Synthesis of Ginsenoside Re-Based Carbon Dots Applied for Bioimaging and Effective Inhibition of Cancer Cells [Corrigendum] Open
Yao H, Li J, Song Y, et al. Int J Nanomedicine. 2018;13:6249–6264.\nThe authors have advised due to an error at the time of figure assembly, the β-actin of Figure 8D on page 6261 is incorrect a…
View article: Preoperative Immune Prognostic Index Can Predict the Clinical Outcomes of Patients with Gallbladder Cancer: Single-Center Experience
Preoperative Immune Prognostic Index Can Predict the Clinical Outcomes of Patients with Gallbladder Cancer: Single-Center Experience Open
Lejia Sun,1,* Dongyue Wang,2,* Mengyuan Zhang,2,* Yukai Jin,1 Bao Jin,1 Haifeng Xu,1 Shunda Du,1 Yiyao Xu,1 Haitao Zhao,1 Xin Lu,1 Xinting Sang,1 Shouxian Zhong,1 Huayu Yang,1 Yilei Mao1 1Department of Liver Surgery, Peking Union Medical C…