Yan Liang
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View article: Cost-effectiveness analysis of first-line treatment for advanced soft tissue sarcomas in China
Cost-effectiveness analysis of first-line treatment for advanced soft tissue sarcomas in China Open
Conventional chemotherapy, specifically using doxorubicin injection, represents the most cost-effective first-line treatment for advanced STS. However, this conclusion is sensitive to the chemotherapy composition; if the more expensive lip…
View article: Wogonin-Derived Chemotype Enables Discovery of Novel GLS1 Inhibitors with Potent Antitumor Activity
Wogonin-Derived Chemotype Enables Discovery of Novel GLS1 Inhibitors with Potent Antitumor Activity Open
View article: Detection of an Orphan X-ray Flare from a Blazar Candidate EP240709a with Einstein Probe
Detection of an Orphan X-ray Flare from a Blazar Candidate EP240709a with Einstein Probe Open
Blazars are often observed to flare across multiple wavelengths. Orphan flares from blazars have been only detected a few times, providing an opportunity to understand the structure of the jet in the accreting system. We report a remarkabl…
View article: Cost‐Effectiveness Analysis of Adjuvant Alectinib versus Platinum‐Based Chemotherapy in Resected <scp>ALK</scp>‐Positive Non‐Small‐Cell Lung Cancer in the Chinese Health Care System
Cost‐Effectiveness Analysis of Adjuvant Alectinib versus Platinum‐Based Chemotherapy in Resected <span>ALK</span>‐Positive Non‐Small‐Cell Lung Cancer in the Chinese Health Care System Open
Objectives The ALINE trial demonstrated the superiority of alectinib over platinum‐based chemotherapy in resected Anaplastic Lymphoma Kinase (ALK)‐positive non‐small‐cell lung cancer (NSCLC). Considering the high cost of alectinib, this st…
View article: SDS-YOLOv8n: A lightweight detection method for flames and smoke
SDS-YOLOv8n: A lightweight detection method for flames and smoke Open
In flame and smoke image processing scenarios, real-time detection of translucent flames and smoke targets is a difficult task. In the process of optimizing accuracy and speed, this study proposed an SDS-YOLOv8n lightweight detection netwo…
View article: Feasibility exploration of GSH in the treatment of acute hepatic encephalopathy from the aspects of pharmacokinetics, pharmacodynamics, and mechanism
Feasibility exploration of GSH in the treatment of acute hepatic encephalopathy from the aspects of pharmacokinetics, pharmacodynamics, and mechanism Open
Our previous study highlighted the therapeutic potential of glutathione (GSH), an intracellular thiol tripeptide ubiquitous in mammalian tissues, in mitigating hepatic and cerebral damage. Building on this premise, we posited the hypothesi…
View article: Comprehensive Analysis of 11 Species of Euodia (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods
Comprehensive Analysis of 11 Species of Euodia (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods Open
The Euodia genus comprises numerous untapped medicinal plants that warrant thorough evaluation for their potential as valuable natural sources of herbal medicine or food flavorings. In this study, untargeted metabolomics and in vitro funct…
View article: Schisandra lignans ameliorate nonalcoholic steatohepatitis by regulating aberrant metabolism of phosphatidylethanolamines
Schisandra lignans ameliorate nonalcoholic steatohepatitis by regulating aberrant metabolism of phosphatidylethanolamines Open
View article: Mass Spectrometry Imaging as a New Method: To Reveal the Pathogenesis and the Mechanism of Traditional Medicine in Cerebral Ischemia
Mass Spectrometry Imaging as a New Method: To Reveal the Pathogenesis and the Mechanism of Traditional Medicine in Cerebral Ischemia Open
Mass spectrometry imaging (MSI) can describe the spatial distribution of molecules in various complex biological samples, such as metabolites, lipids, peptides and proteins in a comprehensive way, and can provide highly relevant supplement…
View article: Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine
Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine Open
View article: Multiomics Profiling Reveals Protective Function of Schisandra Lignans against Acetaminophen-Induced Hepatotoxicity
Multiomics Profiling Reveals Protective Function of Schisandra Lignans against Acetaminophen-Induced Hepatotoxicity Open
View article: Comparative analysis of constitutes and metabolites for traditional Chinese medicine using IDA and SWATH data acquisition modes on LC-Q-TOF MS
Comparative analysis of constitutes and metabolites for traditional Chinese medicine using IDA and SWATH data acquisition modes on LC-Q-TOF MS Open
Identification of components and metabolites of traditional Chinese medicines (TCMs) employing liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF MS) techniques with information-dependent acquisition (IDA) approach…
View article: Insights into the Authentic Active Ingredients and Action Sites of Oral Exogenous Glutathione in the Treatment of Ischemic Brain Injury Based on Pharmacokinetic-Pharmacodynamic Studies
Insights into the Authentic Active Ingredients and Action Sites of Oral Exogenous Glutathione in the Treatment of Ischemic Brain Injury Based on Pharmacokinetic-Pharmacodynamic Studies Open
View article: Ginsenoside Rb1 exerts neuroprotective effects through regulation of Lactobacillus helveticus abundance and GABAA receptor expression
Ginsenoside Rb1 exerts neuroprotective effects through regulation of Lactobacillus helveticus abundance and GABAA receptor expression Open
View article: Is the combinational administration of doxorubicin and glutathione a reasonable proposal?
Is the combinational administration of doxorubicin and glutathione a reasonable proposal? Open
View article: Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury
Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury Open
View article: Low Cerebral Exposure Cannot Hinder the Neuroprotective Effects of Panax Notoginsenosides
Low Cerebral Exposure Cannot Hinder the Neuroprotective Effects of Panax Notoginsenosides Open
View article: Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study
Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study Open
View article: Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender Open
View article: Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms
Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms Open
Oseltamivir, an inactive anti‐influenza virus prodrug, is activated (hydrolysed) in vivo by carboxylesterase 1 ( CES 1) to its active metabolite oseltamivir carboxylate. CES 1 functions are significantly associated with certain CES 1 genet…
View article: <b>Targeted absolute quantitative proteomics with SILAC internal standards and unlabeled full‐length protein calibrators (TAQSI)</b>
<b>Targeted absolute quantitative proteomics with SILAC internal standards and unlabeled full‐length protein calibrators (TAQSI)</b> Open
Rationale Liquid Chromatography/Mass Spectrometry (LC/MS)‐based proteomics for absolute protein quantification has been increasingly utilized in both basic and clinical research. There is a great need to overcome some major hurdles of curr…
View article: Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection
Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection Open
Compounds that have the ability to both strengthen synaptic function and facilitate neuroprotection are valuable cognitive enhancers that may improve health and quality of life, as well as retard age-related cognitive deterioration. Medici…