Yifei Cheng
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View article: Correction: Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion
Correction: Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion Open
View article: High serum Isthmin-1 as a biomarker of chronic kidney disease progression in patients with type 2 diabetes mellitus
High serum Isthmin-1 as a biomarker of chronic kidney disease progression in patients with type 2 diabetes mellitus Open
Objectives To determine the relationship between serum Ism-1 levels and chronic kidney disease (CKD) progression in patients with T2DM. Methods This prospective longitudinal study included 223 patients with T2DM. Patients were divided into…
View article: Exploring the Needs and Preferences of Patients with Port-Wine Stain and Associated Syndromes: A Qualitative Analysis of Social Media Discussions
Exploring the Needs and Preferences of Patients with Port-Wine Stain and Associated Syndromes: A Qualitative Analysis of Social Media Discussions Open
This study distilled key needs from authentic patient expressions and found that beyond clinical diagnosis and treatment, PWS patients also highly value emotional support and anxiety relief regarding relapse. These findings underscore the …
View article: A Novel Self‐Regulated, Non‐Directional Magnetic Thermos‐Brachytherapy <sup>125</sup> I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape
A Novel Self‐Regulated, Non‐Directional Magnetic Thermos‐Brachytherapy <sup>125</sup> I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape Open
Integrating mild hyperthermia (MH) with 125 I brachytherapy holds potential for overcoming treatment resistance and improving anticancer efficacy. Here, magnetic nanoparticles (MNPs) with a suitable Curie temperature are constructed and in…
View article: Exploring Melasma Patients’ Needs Through Social Media: A Qualitative Study
Exploring Melasma Patients’ Needs Through Social Media: A Qualitative Study Open
This study identified key concerns of patients with melasma using AI-based keyword extraction and qualitative analysis, highlighting the need for healthcare professionals to engage in digital patient education, clarify misinformation, supp…
View article: [Diagnostic value of targeted next-generation sequencing for community-acquired respiratory virus infections in patients with hematological diseases].
[Diagnostic value of targeted next-generation sequencing for community-acquired respiratory virus infections in patients with hematological diseases]. Open
Objective: To evaluate the diagnostic value of targeted next-generation sequencing (tNGS) of throat swab samples for detecting community-acquired respiratory viruses (CARV) in patients with hematological diseases. Methods: Cl…
View article: Biomimetic Desert Beetle Microgrinding Tool Flow-field Model and Processability Evaluation
Biomimetic Desert Beetle Microgrinding Tool Flow-field Model and Processability Evaluation Open
Microgrinding is widely used in clinical bone surgery, but saline spray cooling faces technical challenges such as low wettability at the microgrinding tool–bone interface, easy clogging of the microgrinding tools, and high grinding temper…
View article: Incidence, Risk Factors, and Impact on Transplant Outcomes of Cytokine Release Syndrome After Infusion of Haploidentical Stem Cells With Anti‐Thymocyte Globulin
Incidence, Risk Factors, and Impact on Transplant Outcomes of Cytokine Release Syndrome After Infusion of Haploidentical Stem Cells With Anti‐Thymocyte Globulin Open
Background Cytokine release syndrome (CRS) after graft infusion under anti‐thymocyte globulin (ATG)–based haploidentical (haplo)‐hematopoietic stem cell transplantation is unclear. Objective The purpose of this study was to explore the cli…
View article: The outcomes of second haploidentical donor transplantation for graft failure in patients with severe aplastic anaemia
The outcomes of second haploidentical donor transplantation for graft failure in patients with severe aplastic anaemia Open
This study aimed to evaluate the outcomes of second haploidentical hematopoietic stem cell transplantation (HID-HSCT) for patients with severe aplastic anaemia (SAA) who experienced graft failure. Twenty-one SAA patients with graft failure…
View article: Outcomes and prognostic factors associated with relapse after haploidentical stem cell transplantation for paediatric T‐cell acute lymphoblastic leukaemia
Outcomes and prognostic factors associated with relapse after haploidentical stem cell transplantation for paediatric T‐cell acute lymphoblastic leukaemia Open
Summary The outcomes are poor for paediatric patients with T‐cell acute lymphoblastic leukaemia (T‐ALL) who relapse after haematopoietic stem cell transplantation (HSCT). However, studies focusing on paediatric patients with T‐ALL followin…
View article: Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma
Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma Open
Dissecting the spatial heterogeneity of cancer-associated fibroblasts (CAFs) is vital for understanding tumor biology and therapeutic design. By combining pathological image analysis with spatial proteomics, we revealed two stromal archety…
View article: [Clinical characteristics of HHV-6 infection after allogeneic hematopoietic stem cell transplantation].
[Clinical characteristics of HHV-6 infection after allogeneic hematopoietic stem cell transplantation]. Open
Objective: This study aimed to analyze the clinical manifestations of human herpesvirus 6 (HHV-6) infection within 100 days after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and to investigate the association of H…
View article: [Efficacy and safety of venetoclax combined with decitabine, modified HA regimen and DLI in the treatment of relapsed pediatric AML/MDS after allogeneic hematopoietic stem cell transplantation].
[Efficacy and safety of venetoclax combined with decitabine, modified HA regimen and DLI in the treatment of relapsed pediatric AML/MDS after allogeneic hematopoietic stem cell transplantation]. Open
Objective: To investigate the efficacy and safety of venetoclax combined with the decitabine, cytarabine, and homoharringtonine (HHT) regimen and donor lymphocyte infusion (DLI) for the preventive and salvage therapy of pediatric ac…
View article: Fertility assessment in long-term young female survivors with hematological disease after allogeneic hematopoietic cell transplantation: a single-center real-life cross-sectional study
Fertility assessment in long-term young female survivors with hematological disease after allogeneic hematopoietic cell transplantation: a single-center real-life cross-sectional study Open
HSCT has been recognized as a successful treatment for various hematological disease. The 5-year survival rate for children and adolescents diagnosed with hematological disease has risen to over 90% in high-income countries. Nevertheless, …
View article: Risk factors for positive post-transplantation measurable residual disease in patients with acute lymphoblastic leukemia
Risk factors for positive post-transplantation measurable residual disease in patients with acute lymphoblastic leukemia Open
Background: The level of measurable residual disease (MRD) before and after transplantation is related to inferior transplant outcomes, and post-hematopoietic stem cell transplantation measurable residual disease (post-HSCT MRD) has higher…
View article: piRNA PROPER Suppresses <i>DUSP1</i> Translation by Targeting <i>N</i><sup>6</sup>‐Methyladenosine‐Mediated RNA Circularization to Promote Oncogenesis of Prostate Cancer
piRNA PROPER Suppresses <i>DUSP1</i> Translation by Targeting <i>N</i><sup>6</sup>‐Methyladenosine‐Mediated RNA Circularization to Promote Oncogenesis of Prostate Cancer Open
Genetic and epigenetic alterations occur in many physiological and pathological processes. The existing knowledge regarding the association of PIWI‐interacting RNAs (piRNAs) and their genetic variants on risk and progression of prostate ca…
View article: Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion
Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion Open
Background Gallbladder cancer (GBC) is the most common and lethal malignancy of the biliary tract that lacks effective therapy. In many GBC cases, infiltration into adjacent organs or distant metastasis happened long before the diagnosis, …
View article: Incidence, risk factors and impact on transplant outcomes of cytokine release syndrome after infusion of haploidentical stem cells with anti-thymocyte globulin
Incidence, risk factors and impact on transplant outcomes of cytokine release syndrome after infusion of haploidentical stem cells with anti-thymocyte globulin Open
Cytokine release syndrome (CRS) after stem cell infusion in anti-thymocyte globulin (ATG)-based haploidentical (haplo)-hematopoietic stem cell transplantation (SCT) is unclear. We reviewed charts of patients who underwent haplo-SCT between…
View article: Salvage Haploidentical Transplantation for Graft Failure after First Haploidentical Allogeneic Stem Cell Transplantation: An Updated Experience
Salvage Haploidentical Transplantation for Graft Failure after First Haploidentical Allogeneic Stem Cell Transplantation: An Updated Experience Open
Second transplantation was almost the only salvage for graft failure. However, there is no recommended regimens for second transplantation, especially in the haplo-SCT setting. We recently reported very encouraging outcomes using a novel m…
View article: [Impact of SARS-CoV-2 infection on graft composition and early transplant outcomes following allogeneic hematopoietic stem cell transplantation].
[Impact of SARS-CoV-2 infection on graft composition and early transplant outcomes following allogeneic hematopoietic stem cell transplantation]. Open
Objective: To assess the feasibility of using donors with novel coronavirus disease 2019 (COVID-19) for allogeneic hematopoietic stem cell transplantation (allo-HSCT) when there are no other available donors and allo-HSCT cannot be …
View article: 4SCAR2.0 therapy for the management of post-transplantation relapse of B-cell acute lymphoblastic leukemia
4SCAR2.0 therapy for the management of post-transplantation relapse of B-cell acute lymphoblastic leukemia Open
Introduction Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a standard treatment for relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL). However, about 30-40% of patients still relapse after HCT. Chimeric…
View article: Outcomes and prognosis of haploidentical haematopoietic stem cell transplantation in children with FLT3-ITD mutated acute myeloid leukaemia
Outcomes and prognosis of haploidentical haematopoietic stem cell transplantation in children with FLT3-ITD mutated acute myeloid leukaemia Open
The presence of internal tandem duplication mutations in the FMS-like tyrosine kinase 3 receptor ( FLT3-ITD ) is a poor prognostic predictor in paediatric patients with acute myeloid leukaemia (AML). We evaluated the treatment outcomes and…
View article: Targeting TFH cells is a novel approach for donor-specific antibody desensitization of allograft candidates: an <i>in vitro</i> and <i>in vivo</i> study
Targeting TFH cells is a novel approach for donor-specific antibody desensitization of allograft candidates: an <i>in vitro</i> and <i>in vivo</i> study Open
The presence of donor-specific antibodies (DSAs) are associated with graft failure either following HLA-mismatched allogeneic stem cell transplantation or after organ transplantation. Although targeting B cells and plasma cells have been u…
View article: Comparison of clinical features of nephrotic syndrome after haploidentical and matched donor hematopoietic stem cell transplantation
Comparison of clinical features of nephrotic syndrome after haploidentical and matched donor hematopoietic stem cell transplantation Open
To the Editor: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most effective options for hematological diseases. However, allo-HSCT treatment can cause serious complications. Post-transplant kidney damage is a…
View article: P1300: CLINICAL CHARACTERISTICS AND OUTCOMES OF ALLOGENEIC STEM CELL TRANSPLANTATION RECIPIENTS WITH CORONAVIRUS DISEASE 2019 CAUSED BY THE OMICRON VARIANT: A PROSPECTIVE, OBSERVATIONAL COHORT STUDY
P1300: CLINICAL CHARACTERISTICS AND OUTCOMES OF ALLOGENEIC STEM CELL TRANSPLANTATION RECIPIENTS WITH CORONAVIRUS DISEASE 2019 CAUSED BY THE OMICRON VARIANT: A PROSPECTIVE, OBSERVATIONAL COHORT STUDY Open
Topic: 22. Stem cell transplantation - Clinical Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients are the most representative immunocompromised patients. COVID-19 infection has an adverse influence on cl…
View article: P1317: TIME-DEPENDENT ANALYSIS OF THE IMPACT ON EARLY CMV REACTIVATION OF HLA MISMATCH AND ACUTE GRAFT-VERSUS-HOST-DISEASE AFTER ALLO-HSCT FROM RELATED DONORS IN ACQUIRED APLASTIC ANEMIA.
P1317: TIME-DEPENDENT ANALYSIS OF THE IMPACT ON EARLY CMV REACTIVATION OF HLA MISMATCH AND ACUTE GRAFT-VERSUS-HOST-DISEASE AFTER ALLO-HSCT FROM RELATED DONORS IN ACQUIRED APLASTIC ANEMIA. Open
Topic: 22. Stem cell transplantation - Clinical Background: Cytomegalovirus (CMV) reactivation is an important issue in allogeneic hematopoietic cell transplantation (HCT). Studies have found higher incidences of CMV reactivation in HLA-mi…
View article: Bridging chimeric antigen receptor T-cell before transplantation improves prognosis of relapsed/refractory B-cell acute lymphoblastic leukemia
Bridging chimeric antigen receptor T-cell before transplantation improves prognosis of relapsed/refractory B-cell acute lymphoblastic leukemia Open
To the Editor: For recipients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL), allogeneic hematopoietic stem cell transplantation (allo-HSCT) often fails to provide them with a satisfactory prognosis. The chimeri…
View article: Unmanipulated haploidentical hematopoietic stem cell transplantation for mixed phenotype acute leukemia: a single center study
Unmanipulated haploidentical hematopoietic stem cell transplantation for mixed phenotype acute leukemia: a single center study Open
Mixed-phenotype acute leukemia (MPAL), which is categorized as a rare subtype of acute leukemia with a generally dismal prognosis. Hemopoietic stem cell transplantation (HSCT) is traditionally considered a curative treatment for MPAL. Thir…
View article: [Efficacy and safety of secondary allogeneic hematopoietic stem cell transplantation in 70 patients with recurrent hematologic malignancies after transplantation].
[Efficacy and safety of secondary allogeneic hematopoietic stem cell transplantation in 70 patients with recurrent hematologic malignancies after transplantation]. Open
Objectives: To investigate the role of donor change in the second hematopoietic stem cell transplantation (HSCT2) for hematological relapse of malignant hematology after the first transplantation (HSCT1) . Methods: We retrosp…
View article: Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated <i>FAM227A</i> expression
Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated <i>FAM227A</i> expression Open
Genetic variants in super-enhancers (SEs) are increasingly implicated as a disease risk-driving mechanism. Previous studies have reported an associations between benzo[a]pyrene (BaP) exposure and some malignant tumor risk. Currently, it is…