Explanipedia

Evolving HPV diagnostics: current practice and future frontiers Open

Lin Shi, Haizhen Chen, Zichen Zhang, Yifei Wang, Wenbo Ren , et al. · 2025

Human papillomavirus (HPV) infection serves as a primary causative agent of cervical cancer, highlighting the importance of early screening and detection in mitigating the incidence and mortality rates of HPV-related diseases. Over the pas…

Preference for breast cancer screening in Chinese women: Discrete choice experiment Open

Shuning Wu, Jianhao Du, Yifei Wang, Dawei Peng, Xinyang Ma , et al. · 2025

Background Breast cancer is a common tumor in women, which significantly impacts their health and quality of life. The incidence of breast cancer has been increasing globally. Objective This study aimed to investigate the preferences of Ch…

On the Nationwide Variability of Low-Level Jets Prior to Warm-season Nocturnal Rainfall in China Revealed by Radar Wind Profilers Open

Ning Li, Jianping Guo, Xiaoran Guo, Tianmeng Chen, Z. Zhang , et al. · 2025

Nocturnal rainfall initiation is closely linked to low-level jets (LLJs), but national-scale LLJ features over China—especially their evolution preceding warm-seasonal nocturnal rainfall—remain unknown due to scarce high-resolution vertica…

Comparison of repeated human umbilical cord mesenchymal stem cells administration and tetramethylpyrazine combination with single injection of human umbilical cord mesenchymal stem cells in cuprizone-induced demyelinating mice Open

G. Q. Lin, Yang Yang, Aiping Zheng, Yifei Wang, Hong Yu Zhang , et al. · 2025

Introduction : Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination in the central nervous system, which can lead to neurological dysfunction. Our previous studies have showed tetramethylpyrazine…

A combined pseudouridine biomanufacturing platform enabled by a streamlined designer pathway Open

Le Yu, Ruyi Chen, Chenyue Zhang, Zhengyuan Wang, Zhuqing Wang , et al. · 2025

mRNA vaccines, featured by incorporated pseudouridine (Ψ), represent a milestone in combating diseases, thus highlighting Ψ importance in drug development. However, economic and environmental challenges have persisted in sustainable Ψ prod…

Interaction between hyaluronic acid and phospholipid bilayer and its influence on stability and bioavailability of luteolin-loaded liposomes Open

Le Cheng, Ming Zhang, Lin Dong, Yifei Wang, Jianguo Dong , et al. · 2025

The poor solubility of luteolin limits its food applications, and while liposomes offer a potential delivery solution, their phospholipid bilayer membranes are unstable. To overcome these dual challenges, this study developed hyaluronic ac…

SDFA: a standardized decomposition format and toolkit for efficient analysis of structural variants in large-scale population genomic studies Open

Wenjie Peng, Liubin Zhang, Bin Tang, Junhao Liang, Zhi Liu , et al. · 2025

INHBA knockdown inhibits renal fibrosis in mice following ischemia–reperfusion injury by suppressing activation of the TGF-β/Smad signaling pathway Open

Yifei Wang, Qiao Tang, Qian Sun · 2025

The origin of circulating microbial DNA in the blood: where does it come from? Open

Zhang Zichen, Wenbo Ren, Yifei Wang, Taiyu Zhai, Jing Huang · 2025

The potential sources of cmDNA in the blood are not mutually exclusive and may be multifaceted, depending on an individual's health condition, sampling time, and contamination control. In-depth study of these sources will open new avenues …

Rootstock-specific bacterial microbiome and metabolome remodeling enhances glycine substitution efficacy for ammonium nitrate in watermelon Open

Zhenwei Chen, Yao Tian, Xingfeng Bao, Yifei Wang, Shiyan Qiao , et al. · 2025

Introduction Optimizing nitrogen sources and rootstock selection is crucial for sustainable watermelon production. However, the synergistic mechanisms between organic nitrogen forms and rootstocks remain poorly understood. This study inves…

A single-cell transcriptome atlas of pig skin reveals cellular heterogeneity from embryonic development to postnatal aging Open

Ting Zheng, Rong Yuan, Yu Zhang, Qin Zou, Yifei Wang , et al. · 2025

This work delineates cellular dynamics underpinning skin homeostasis, uncovers the vital physiological functions of FBs and immune cells during skin development and aging, and validates the pig model for human cutaneous physiology research…

Divergent Sounding‐Derived Precursor Pathways Enable Discrimination of Dry Versus Wet Severe Convective Winds Open

Qian Cao, Jianping Guo, Chenbin Xue, Zhibo Li, Hui Xu , et al. · 2025

Forecasting Severe Convective Wind (SCW) events remains challenging due to unresolved precursors. Using 8‐year (2016–2023) high‐resolution soundings from China radiosonde network, we establish observational pre‐SCW thresholds, revealing di…

Chromosome-level genome assembly of hawthorn spider mite, Amphitetranychus viennensis (Acari: Tetranychidae) Open

Meifeng Ren, Yuying Zhang, Yifei Wang, Yuanpeng Duan, Yue Gao , et al. · 2025

To explore the therapeutic effect and mechanism of simmered ginseng wrapped with yellow mud on spleen-kidney yang deficiency rats before and after preparation Open

Junwei Sun, Miao Zhang, Qi Chu, Yifei Wang, Junhua Luo , et al. · 2025

The impact of KIAA1429 on proliferation and invasion in oral cancer via LINC00958 methylation Open

Pengjun Zhou, Wanning Li, Meiyi Ye, Chunlan Chen, Yifei Wang · 2025

Introduction The investigation focused on the function of LINC00958 in the development of oral cancer, as well as the influence of methylation on tumor formation. Methods To explore the role of LINC00958, both its overexpression and its me…

Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects Open

Yifei Wang, Xiaoqiong Duan, Zhiqi Li, Yuanming Pan, Jianhua Deng · 2025

Palmitoylethanolamide (PEA) has attracted increasing attention from researchers as an endogenous lipid mediator. It exhibits a unique mechanism of action in alleviating pain, controlling inflammation, and providing neuroprotection. It prim…

Exploring the molecular characteristics of inflammatory bowel disease from the perspective of hypoxia-related genes Open

Lei Zheng, Lin Mou, Lili Hao, Rui Chen, Yifei Wang , et al. · 2025

Background Inflammatory bowel disease (IBD) constitutes a chronic inflammatory disorder affecting the gastrointestinal tract, characterized by a multifaceted pathogenesis that encompasses genetic, environmental, and immunological influence…

Circadian rhythms of gut microbiota and plaque vulnerability: mechanisms and chrono-microbiota modulation interventions Open

Taiyu Zhai, Xueyang Zou, Zichen Zhang, Yifei Wang, Lin Shi , et al. · 2025

The stability of atherosclerotic plaques constitutes the fundamental pathological basis for acute cardiovascular events, and their circadian rhythm characteristics highlight the essential role of dynamic interactions between the host and m…

SIRT2 and NAD+ Boosting Broadly Suppress Aging‐Associated Inflammation Open

Marine Barthez, Zehan Song, Y P Feng, Yifei Wang, Chih-Ling Wang , et al. · 2025

Aging leads to chronic inflammation that is linked to aging‐associated conditions and diseases. Multiple immune pathways become activated during aging, posing a challenge to effectively reduce aging‐associated inflammation. SIRT2, an NAD +…

Dual Effects of PVC Microplastics on Cd Mobility in Red Soil: Enhanced Aqueous Concentration Versus Reduced Soil Bioavailability Open

Shanshan Deng, Xin Wan, Xian Zhou, Shengwu Yuan, Xia Chen , et al. · 2025

Microplastic and cadmium (Cd) co‐contamination affects Cd fate in soil‐water systems. However, it remains unclear whether soil type regulates the microplastic‐induced changes in Cd bioavailability. Moreover, the effects of microplastics on…

The necessity and challenges of human papillomavirus testing for men Open

Wenbo Ren, Yu-Ting Jin, Lin Shi, Haizhen Chen, Zichen Zhang , et al. · 2025

Beyond its historical association with cervical cancer in women, human papillomavirus (HPV) infection poses a widespread health concern, particularly for men. Recent studies have highlighted the prevalence of HPV-related cancers, including…

Computational design and evaluation of multiepitope vaccines against herpes simplex virus type 1 Open

Zibo Zhao, Weixiong Wang, Jodie Pang, Bei Zhou, Xin Li , et al. · 2025

Introduction Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen, causing infections in various tissues and leading to severe complications such as herpes simplex encephalitis and cognitive impairments. Despite existing antiv…

Analysis of Gender Inequality and Its Impact on Innovation in the Creative Industries Open

Yifei Wang · 2025

The creative industry has emerged as a key player in global economic and cultural integration, contributing significantly to GDP, employment, and export trade across various countries. However, despite its openness, innovation, and diversi…

DOCK2 protects against bacterial sepsis by constraining T helper 1 response Open

Shusen Ye, Linzi Huang, Yuhao Zheng, Shanshan Liu, Xiangyang Wang , et al. · 2025

Background Sepsis is a systemic host response to infection with life-threatening consequence which ranks among the top ten causes of death worldwide. Nevertheless, our understanding of the molecular and cellular impact of sepsis remains ru…

A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis Open

Shufen Li, Hao Li, Zhenxing Zhou, Meidi Ye, Yifei Wang , et al. · 2025

Necroptosis is an inflammatory programmed cell death pathway triggered by RIPK3 activation through one of the upstream RHIM-domain-containing proteins including RIPK1, TRIF, and ZBP1. Whether necroptosis can be activated independent of the…

SDFA: A Standardized Decomposition Format and Toolkit for Efficient Analysis of Structural Variants in Large-scale Population Genomic Studies Open

Wenjie Peng, Liubin Zhang, Bin Tang, Junhao Liang, Zhi Liu , et al. · 2025

Structural variants (SVs) contribute significantly to genetic diversity yet present computational challenges during analysis. We introduce SDFA, a standardized decomposition format and toolkit for efficient analysis of SVs in large-scale p…

HS-STaR: Hierarchical Sampling for Self-Taught Reasoners via Difficulty Estimation and Budget Reallocation Open

Feng Xiong, Honglin Li, Yifei Wang, Ran Cheng, Yong Wang , et al. · 2025

Self-taught reasoners (STaRs) enhance the mathematical reasoning abilities of large language models (LLMs) by leveraging self-generated responses for self-training. Recent studies have incorporated reward models to guide response selection…

StructEval: Benchmarking LLMs' Capabilities to Generate Structural Outputs Open

Jialin Yang, Dongfu Jiang, Lipeng He, Sherman Siu, Yuxuan Zhang , et al. · 2025

As Large Language Models (LLMs) become integral to software development workflows, their ability to generate structured outputs has become critically important. We introduce StructEval, a comprehensive benchmark for evaluating LLMs' capabi…

Chromosome-level genome assembly for clubrush (Scirpus × mariqueter) endemic to China Open

Yu Ning, Yang Li, Chun Yi Li, Jin Zhi Wang, T. Wang , et al. · 2025

Scirpus × mariqueter (Tang & F.T.Wang) Tatanov, which is endemic to eastern estuaries in China, is a tidal zone-engineering species with great promise for managing greenhouse gases and enhancing ecosystem resilience against invasive specie…

Targeting CIDEB alleviates liver steatosis and fibrosis in mouse MASH models Open

Yingying Lin, Fushun Fan, Zhenxian Mo, Ziyang Huang, Minhua Zhou , et al. · 2025

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