Explanipedia

The Role of HBx Mutations in Chronic Hepatitis B with Acute Exacerbation Open

Xiaobei Chen, Jinzhi Shi, Ping Zhou, Yunyun Tian, Yajing Zheng , et al. · 2025

Hepatitis B virus (HBV) infection remains a significant global health burden, primarily due to its chronic complications, including acute exacerbation, cirrhosis, hepatocellular carcinoma (HCC), and related sequelae. Acute exacerbation of …

The adaptation of the infertility distress scale into Chinese: cross-cultural adaptation, reliability and validity Open

Siyan Liu, Pei Zhang, Xian Tian, Ling-Rong Xiao, Junru Li , et al. · 2025

Background and problem Women with infertility frequently experience unique psychological challenges. However, the commonly used universal distress scales may not adequately represent their actual psychological state. Objective This study f…

Construction of Multiplexed Assays on Single Anisotropic Particles Using Microfluidics Open

Zengnan Wu, Yajing Zheng, Ling Lin, Gaowa Xing, Tianze Xie , et al. · 2025

Considerable efforts have been made to develop microscale multiplexing strategies. However, challenges remain due to the difficulty in deploying functional objects and decoding high-density signals on anisotropic microcarriers. Here, we re…

Progress on cadmium-ion and ytterbium-ion Microwave Frequency Standards at Tsinghua University Open

S. N. Miao, Yajing Zheng, Yong Chen, Wenxiong Shi, Jianwei Zhang , et al. · 2024

As a candidate for the next generation microwave clock, microwave atomic clocks based on trapped ions are currently studied worldwide. Since 2010, our team at Tsinghua University has been committed to developing a high-performance 113 Cd +…

Mini-LED Backlight: Advances and Future Perspectives Open

Ji Lei, Hengli Zhu, Xiao Huang, Junjie Lin, Yajing Zheng , et al. · 2024

Miniaturized-light-emitting diode (mini-LED) backlights have emerged as the state-of-the-art technology for liquid crystal display (LCD), facilitating the improvement in a high dynamic range (HDR) and power saving. The local dimming techno…

Absolute frequency measurement of molecular iodine hyperfine transitions at 554 nm and its application to stabilize a 369 nm laser for Yb+ ions cooling Open

Y. T. Chen, N. C. Xin, H. R. Qin, S. N. Miao, Yajing Zheng , et al. · 2023

We investigate 13 hyperfine structures of transition lines of 127I2 near 554 nm, namely, the R(50) 22-0, P(46) 22-0, P(121) 24-0, P(69) 25-1, R(146) 25-0, R(147) 28-1, P(160) 26-0, P(102) 26-1, R(96) 23-0, R(49) 22-0, P(45) 22-0, P(92) 23-…

Precise determination of ground-state hyperfine splitting and calculation of Zeeman coefficients for 171Yb+ microwave frequency standard Open

J. Z. Han, B. Q. Lu, N. C. Xin, Yanmei Yu, H. R. Qin , et al. · 2023

We report precise measurement of the hyperfine splitting and calculation of the Zeeman coefficients of the $^{171}$Yb$^+$ ground state. The absolute hyperfine splitting frequency is measured using high-resolution laser-microwave double-res…

Second-order Doppler frequency shifts of trapped ions in a linear Paul trap Open

S. N. Miao, Jianwei Zhang, Yajing Zheng, H. R. Qin, N. C. Xin , et al. · 2022

The accurate evaluation of the second-order Doppler frequency shift (SODFS)\nof trapped ions in a linear Paul trap has been studied with experiments and\nmolecular dynamics (MD) simulations. The motion of trapped ions in the trap has\nthre…

The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome Open

Mali Wu, Jie Zhang, Ran Gu, Fangfang Dai, Dongyong Yang , et al. · 2022

Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice Open

Yajing Zheng, Juan He, Dongyong Yang, Mengqin Yuan, Shiyi Liu , et al. · 2022

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women, with clinical manifestations of anovulation and hyperandrogenaemia. The treatment of PCOS mainly focuses on improving clinical symptoms, such as insulin…

The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion Open

Ronghui Zhu, Fangfang Dai, Dongyong Yang, Shiyi Liu, Yajing Zheng , et al. · 2022

Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies that are clinically established early in pregnancy. To date, the etiology and underlying mechanisms of RSA remain unclear. It i…

Laser-cooled 171Yb+ microwave frequency standard with a short-term frequency instability of 8.5 × 10−13/√τ Open

N. C. Xin, H. R. Qin, S. N. Miao, Y. T. Chen, Yajing Zheng , et al. · 2022

We report on the development of a microwave frequency standard based on a laser-cooled ion trap system. The electronics , lasers, and magnetic shields are integrated into a single physical package. With over 10 5 ions ar…

In-situ Polymerized Ionic Liquids in Polyester Fiber Composite Membranes for Ultrasensitive Detection of Trace Oil Open

Ruying Wang, Yajing Zheng, Xuejiao Liu, Tongwang Chen, Nan Li , et al. · 2022

Integrated Bioinformatic Analysis of DNA Methylation and Immune Infiltration in Endometrial Cancer Open

Fangfang Dai, Jinglin Wu, Zhimin Deng, Hengxing Li, Wei Tan , et al. · 2022

Background . Endometrial cancer greatly threatens the health of female. Emerging evidences have demonstrated that DNA methylation and immune infiltration are involved in the occurrence and development of endometrial cancer. However, the me…

Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy Open

Dongyong Yang, Fangfang Dai, Mengqin Yuan, Yajing Zheng, Shiyi Liu , et al. · 2021

Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied extensively. It plays an important role in regulating the differe…

Landscape of Immune Microenvironment in Epithelial Ovarian Cancer and Establishing Risk Model by Machine Learning Open

Shiyi Liu, Ronghui Zhu, Zitao Wang, Wei Tan, Li Zhang , et al. · 2021

Background. Epithelial ovarian cancer (EOC) is an extremely lethal gynecological malignancy and has the potential to benefit from the immune checkpoint blockade (ICB) therapy, whose efficacy highly depends on the complex tumor microenviron…

Integrated Bioinformatic Analysis of DNA Methylation and Immune Infiltration in Endometrial Cancer Open

Fangfang Dai, Zhimin Deng, Wei Shen Tan, Mengqin Yuan, Dongyong Yang , et al. · 2021

Background: Endometrial cancer greatly threatens the health of female. Emerging evidences demonstrated that the DNA methylation and immune infiltration involve in the occurrence and development of endometrial cancer. However, the mechanism…

Advances in molecular mechanisms of pelvic organ prolapse (Review) Open

Zhimin Deng, Fangfang Dai, Mengqin Yuan, Dongyong Yang, Yajing Zheng , et al. · 2021

Pelvic organ prolapse (POP) is a common gynecological benign disease occurring in middle-aged and elderly females. Its incidence increases every year. To date, the majority of studies investigating its etiology have not evaluated the under…

Correction to: CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC) Open

Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai , et al. · 2021

Prognostic Implication of a Novel Metabolism-Related Gene Signature in Hepatocellular Carcinoma Open

Chaoyan Yuan, Mengqin Yuan, Mingqian Chen, Jinhua Ouyang, Wei Tan , et al. · 2021

Background Hepatocellular carcinoma (HCC) is one of the main causes of cancer-associated deaths globally, accounts for 90% of primary liver cancers. However, further studies are needed to confirm the metabolism-related gene signature relat…

Silencing of lncRNA UCA1 inhibited the pathological progression in PCOS mice through the regulation of PI3K/AKT signaling pathway Open

Dongyong Yang, Yanqing Wang, Yajing Zheng, Fangfang Dai, Shiyi Liu , et al. · 2021

Identification of a Nine Immune‐Related lncRNA Signature as a Novel Diagnostic Biomarker for Hepatocellular Carcinoma Open

Mengqin Yuan, Yanqing Wang, Qinqian Sun, Shiyi Liu, Shu Xian , et al. · 2021

Hepatocellular carcinoma (HCC) ranks fifth among common cancers and is the second most common cause of cancer‐related mortality worldwide. This study is aimed at identifying an immune‐related long noncoding RNA (lncRNA) signature as a pote…

[Corrigendum] Molecular mechanism of extracellular matrix disorder in pelvic organ prolapses Open

Ping Zhang, Fangfang Dai, Gantao Chen, Yan-Qing Wang, Shiyi Liu , et al. · 2020

Subsequently to the publication of the above article, the authors have realized that the bar charts shown for Fig. 3A and B, as they appeared in the paper, were the same as the bar charts shown for Fig. 4B and D. Fig. 3, as it should have …

CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC) Open

Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai , et al. · 2020

Background Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers. However, its application in clear cell renal cell carcinoma (ccRCC) is…

Molecular mechanism of extracellular matrix disorder in pelvic organ prolapses Open

Ping Zhang, Fangfang Dai, Gantao Chen, Yanqing Wang, Shiyi Liu , et al. · 2020

Pelvic organ prolapses (POP) notably reduces the quality of life in elderly populations due to bladder and bowel dysfunction, incontinence, and coital problems. Extracellular matrix (ECM) disorder is a pivotal event in the progression of P…

CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC) Open

Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai , et al. · 2020

Background: Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers. However, its application in clear cell renal cell carcinoma (ccRCC) i…

CTLA4 had a profound impact in the landscape of tumor-infiltrating lymphocytes with a high prognosis value in ccRCC Open

Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai , et al. · 2020

Background Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers, however, its application is limited due to the therapy response and th…

ATP-responsive mitochondrial probes for monitoring metabolic processes of glioma stem cells in a 3D model Open

Ling Lin, Linglu Yi, Fanghao Zhao, Zengnan Wu, Yajing Zheng , et al. · 2020

The metastatic cascade of cancer stem cells (CSCs) is always accompanied by elevated levels of adenosine triphosphate (ATP) as well as the alteration of energy metabolism to support their differentiation and migration.

The Prevalence of Depression and Depressive Symptoms among Eye Disease Patients: A Systematic Review and Meta-analysis Open

Yajing Zheng, Xiaohang Wu, Xiaoming Lin, Haotian Lin · 2017

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