Yan Dong
YOU?
Author Swipe
View article: HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis
HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis Open
Emerging evidence from our prior investigations has elucidated the dose-dependent regulatory effects of low-dose ionizing radiation on cellular behaviors including proliferation, migration and differentiation in HLE-B3 lens epithelial cell…
View article: Multi-biomarker score model for predicting fatal outcomes in severe fever with thrombocytopenia syndrome: a multicenter cohort study
Multi-biomarker score model for predicting fatal outcomes in severe fever with thrombocytopenia syndrome: a multicenter cohort study Open
Background Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressive disease with high mortality. This study aims to identify mortality risk factors in SFTS and create a prognostic model for early high-risk patient identi…
View article: Precision medicine for advanced biliary tract cancer in China: current status and future perspectives
Precision medicine for advanced biliary tract cancer in China: current status and future perspectives Open
Biliary tract cancer (BTC) is a rare group of malignancies that develop from the epithelial lining of the biliary tree and have a poor prognosis. Although chemotherapy is the standard of care for patients with advanced BTC in China, its cl…
View article: Association between cardiopulmonary exercise capacity and clinical parameters in post-PCI patients with coronary artery disease from Fujian, China
Association between cardiopulmonary exercise capacity and clinical parameters in post-PCI patients with coronary artery disease from Fujian, China Open
Background Peak oxygen uptake (VO₂peak) assessed by cardiopulmonary exercise testing (CPET) is a key indicator of functional capacity and prognosis in patients with coronary artery disease (CAD) following percutaneous coronary intervention…
View article: Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review)
Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review) Open
Intratumoral microbiota, a critical component of the tumor microenvironment, notably impacts tumor progression through various complex mechanisms such as metabolic regulation, immune system remodeling and genotoxicity. The present review f…
View article: Hnf4α integrates AIF and caspase 3/9 signaling to restrict single and coinfecting pathogens in teleosts
Hnf4α integrates AIF and caspase 3/9 signaling to restrict single and coinfecting pathogens in teleosts Open
Hepatocyte nuclear factor 4 alpha (Hnf4α), a conserved nuclear receptor central to vertebrate liver development and metabolic regulation, emerges here as a pivotal immune regulator in teleosts against complex infectious threats. While its …
View article: Grass carp Trim47 restricts GCRV infection via SPRY domain-mediated autophagic degradation of nonstructural proteins and disruption of viral inclusion bodies
Grass carp Trim47 restricts GCRV infection via SPRY domain-mediated autophagic degradation of nonstructural proteins and disruption of viral inclusion bodies Open
Trim47, a TRIM C-VII subgroup protein characterized by a conserved SPRY domain, has been primarily studied for its ubiquitin-dependent roles in mammals. This study reports a paradigm-shifting finding in teleost immunology: grass carp Trim4…
View article: Comprehensive resolution and classification of the Epstein Barr virus transcriptome
Comprehensive resolution and classification of the Epstein Barr virus transcriptome Open
Virus genomes harbor compacted repertoires of genes and regulatory elements. Through long-read sequencing, we provide a comprehensive Epstein Barr virus (EBV) transcriptome analysis, identifying 1453 transcript isoforms and resolving the m…
View article: Exploring the Immunomodulatory Activity of Atractylodes Rhizome Polysaccharides from Different Origins Based on Gut Microbiota-Short Chain Fatty Acids
Exploring the Immunomodulatory Activity of Atractylodes Rhizome Polysaccharides from Different Origins Based on Gut Microbiota-Short Chain Fatty Acids Open
View article: Panax notoginseng Saponins Improve Angiogenesis in Coronary Heart Disease Based on the microRNA 200a Methylation Pathway
Panax notoginseng Saponins Improve Angiogenesis in Coronary Heart Disease Based on the microRNA 200a Methylation Pathway Open
Our research shows that PNS can improve angiogenesis in rats with MI and hypoxic HCEACs and affect the level of miR200a promoter methylation and miR200a and VEGF molecular pathways.
View article: Genomic evolution and patterns of horizontal gene transfer in Papilio
Genomic evolution and patterns of horizontal gene transfer in Papilio Open
The Papilio genus, known for its ecological and phenotypic diversity, is a valuable model for evolutionary studies. This study conducted a comparative genomic analysis of 11 Papilio species, revealing species-specific gene family expansion…
View article: Comprehensive resolution and classification of the Epstein Barr virus transcriptome
Comprehensive resolution and classification of the Epstein Barr virus transcriptome Open
Virus genomes harbor highly compacted repertoires of genes and regulatory elements. Here, we report the most comprehensive Epstein Barr virus (EBV) transcriptome analysis to date, significantly expanding the number of known transcript isof…
View article: Evaluation of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α in preterm infants with brain injury
Evaluation of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α in preterm infants with brain injury Open
View article: Stress hyperglycemia is associated with poor prognosis in critically ill patients with cardiogenic shock
Stress hyperglycemia is associated with poor prognosis in critically ill patients with cardiogenic shock Open
Background Stress hyperglycemia is now more common in intensive care unit (ICU) patients and is strongly associated with poor prognosis. Whether this association exists in critically ill patients with cardiogenic shock (CS) is unknown. Thi…
View article: Viral reprogramming of host transcription initiation
Viral reprogramming of host transcription initiation Open
Viruses are master remodelers of the host cell environment in support of infection and virus production. For example, viruses typically regulate cell gene expression through modulating canonical cell promoter activity. Here, we show that E…
View article: A novel MMUT splicing variant causing mild methylmalonic acidemia phenotype
A novel MMUT splicing variant causing mild methylmalonic acidemia phenotype Open
View article: MicroRNA750-3p Targets Processing of Precursor 7 to Suppress Rice Black-Streaked Dwarf Virus Propagation in Vector Laodelphax striatellus
MicroRNA750-3p Targets Processing of Precursor 7 to Suppress Rice Black-Streaked Dwarf Virus Propagation in Vector Laodelphax striatellus Open
MicroRNAs (miRNAs) are non-coding RNAs, which, as members of the RNA interference pathway, play a pivotal role in antiviral infection. Almost 80% of plant viruses are transmitted by insect vectors; however, little is known about the intera…
View article: Association of Systemic Inflammatory Response Index with Preeclampsia and Severity of Preeclampsia
Association of Systemic Inflammatory Response Index with Preeclampsia and Severity of Preeclampsia Open
View article: Disentangling the Tissue-Specific Variations of Volatile Flavor Profiles of the Lentinula edodes Fruiting Body
Disentangling the Tissue-Specific Variations of Volatile Flavor Profiles of the Lentinula edodes Fruiting Body Open
For Lentinula edodes, its characteristic flavor is the key determinant for consumer preferences. However, the tissue-specific volatile flavor variations of the fruiting body have been overlooked. Here, we comprehensively investigated the v…
View article: Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression
Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression Open
Background Although the fusion of the transmembrane serine protease 2 gene (TMPRSS2) with the erythroblast transformation-specific-related gene (ERG), or TMPRSS2-ERG, occurs frequently in prostate cancer, its impact on clinical outcomes re…
View article: Systemic Lupus Erythematosus Risk Probability Index: ready for routine use? Results from a Chinese cohort
Systemic Lupus Erythematosus Risk Probability Index: ready for routine use? Results from a Chinese cohort Open
Objectives To evaluate the performance of Systemic Lupus Erythematosus Risk Probability Index (SLERPI) in patients with SLE using a Chinese cohort. Methods The Chinese cohort included 352 patients with and 385 without SLE (control group). …
View article: Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Prostate cancer susceptibility is a polygenic trait. We aimed to examine the controversial diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed two datasets collected from Europeans and one from Afri…
View article: Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Text S1, Text S2, Text S3, Text S4, Figure S1, Table S1, Table S2
View article: Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Prostate cancer susceptibility is a polygenic trait. We aimed to examine the controversial diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed two datasets collected from Europeans and one from Afri…
View article: Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Text S1, Text S2, Text S3, Text S4, Figure S1, Table S1, Table S2
View article: HOG1 Mitogen-Activated Protein Kinase Pathway–Related Autophagy Induced by H2O2 in Lentinula edodes Mycelia
HOG1 Mitogen-Activated Protein Kinase Pathway–Related Autophagy Induced by H2O2 in Lentinula edodes Mycelia Open
Mycelial ageing is associated with ROS and autophagy in Lentinula edodes. However, the underlying cellular and molecular mechanisms between ROS and autophagy remain obscure. This study induced autophagy in L. edodes mycelia through exogeno…
View article: Insights into the Global Transcriptome Response of Lentinula edodes Mycelia during Aging
Insights into the Global Transcriptome Response of Lentinula edodes Mycelia during Aging Open
The spawn of Lentinula edodes and other basidiomycete fungi tend to age with long-term culture. This causes heavy yield losses if aging spawn is used for propagation. In this study, we cultivated dikaryotic L. edodes mycelia in plates for …
View article: SpliceTools, a suite of downstream RNA splicing analysis tools to investigate mechanisms and impact of alternative splicing
SpliceTools, a suite of downstream RNA splicing analysis tools to investigate mechanisms and impact of alternative splicing Open
As a fundamental aspect of normal cell signaling and disease states, there is great interest in determining alternative splicing (AS) changes in physiologic, pathologic, and pharmacologic settings. High throughput RNA sequencing and specia…
View article: Two Strains of Lentinula edodes Differ in Their Transcriptional and Metabolic Patterns and Respond Differently to Thermostress
Two Strains of Lentinula edodes Differ in Their Transcriptional and Metabolic Patterns and Respond Differently to Thermostress Open
Temperature type is one of the key traits determining the cultivation regime of Lentinula edodes. However, the molecular and metabolic basis underling temperature type remain unclear. Here, we investigated the phenotypic, transcriptomic, a…
View article: Malignant endometriosis of the rectovaginal septum: A case report
Malignant endometriosis of the rectovaginal septum: A case report Open