Yigong Shi YOU? Author Swipe

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Inhibitors supercharge kinase turnover through native proteolytic circuits Open

Katharina Kladnik, Xuefei Guo, Matthias Hinterndorfer, Hlib Razumkov, Polina Prokofeva , et al. · 2025

Targeted protein degradation is a pharmacological strategy that relies on small molecules such as proteolysis-targeting chimeras (PROTACs) or molecular glues, which induce proximity between a target protein and an E3 ubiquitin ligase to pr…

PABPC1 expression in papillary renal cell carcinoma and its significance for survival outcomes Open

Cheng Huang, Aichun Long, Tianyun Li, Yigong Shi, Hongfang Li , et al. · 2025

A multidimensional model of ethical challenges in hemodialysis: a qualitative study for specialist physicians Open

Yuxiu Jia, Bin Dong, Yigong Shi, F Zhang · 2025

Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates γδ T Cells Open

Qiang Zhou, Weizhi Xin, Bangdong Huang, Weijie Gao, Wenjia Zhang , et al. · 2025

γδ T cells represent a promising avenue for cancer immunotherapy. The Vγ9Vδ2 T cell receptor (TCR), expressed by the predominant subset of γδ T cells, responds to phosphoantigen (pAg)-engaged butyrophilins (BTNs) on various cancer cells. H…

Structural basis of auxin binding and transport by <i>Arabidopsis thaliana</i> AUX1 Open

Dan Jing, Fang Kong, Xiaoli Lu, Gaoxingyu Huang, Jing Huang , et al. · 2025

Indole-3-acetic acid (IAA), the major form of auxin, is essential for plant growth. Auxin resistant 1 (AUX1), the first identified auxin importer, plays a crucial role in polar auxin transport (PAT). Here, we present cryo-EM structures of …

Cryo-EM structure of DNA-unbound human MCM2–7 complex reveals new disease-relevant regulation Open

Yusong Liu, Mengquan Yang, Ping Lü, Haishan Gao, Maozhou He , et al. · 2025

Chromatin loading of the hexameric replicative helicase MCM2–7 complex requires coordinated interactions with the origin recognition complex (ORC), CDC6, and CDT1. MCM2–7 not bound to DNA forms a single hexamer (SH) with an open DNA entry …

Structural basis of auxin binding and transport by <i>Arabidopsis thaliana</i> AUX1 Open

Dan Jing, Fang Kong, Xiaoli Lu, Gaoxingyu Huang, Jing Huang , et al. · 2025

Indole-3-acetic acid (IAA), the major form of auxin, is essential for plant growth. Auxin-resistant 1 (AUX1), the first identified auxin importer, plays a crucial role in polar auxin transport (PAT). Here we present cryo-EM structures of A…

Reduced Electrical Impedance between the Acupuncture Points Sp6 and Sp9 Open

Yingxian Lu, Lingyu Liu, S. P. Chen, Jie Liu, Jiale Wang , et al. · 2025

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) are biotin-dependent carboxylases (BDCs) that catalyze the metabolism of odd-chain fatty acids, cholesterol, and specific amino acids. For human PCC and MCC, only a…

Author response: Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Human acetyl–coenzyme A (CoA) carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism underlying the dynamic organization of ACCs is largely unknown. He…

Molecular basis for the activation of human spliceosome Open

Xiechao Zhan, Yichen Lu, Yigong Shi · 2024

Reviewer #2 (Public Review): Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) are biotin-dependent carboxylases (BDCs) that catalyze the metabolism of odd-chain fatty acids, cholesterol, and specific amino acids. For human PCC and MCC, only a…

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) are biotin-dependent carboxylases (BDCs) that catalyze the metabolism of odd-chain fatty acids, cholesterol, and specific amino acids. For human PCC and MCC, only a…

Author response: Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) are biotin-dependent carboxylases (BDCs) that catalyze the metabolism of odd-chain fatty acids, cholesterol, and specific amino acids. For human PCC and MCC, only a…

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) are biotin-dependent carboxylases (BDCs) that catalyze the metabolism of odd-chain fatty acids, cholesterol, and specific amino acids. For human PCC and MCC, only a…

Reviewer #1 (Public Review): Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) are biotin-dependent carboxylases (BDCs) that catalyze the metabolism of odd-chain fatty acids, cholesterol, and specific amino acids. For human PCC and MCC, only a…

Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Human acetyl-CoA carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism underlying the dynamic organization of ACCs is largely unknown. Here, we determ…

AI and immunology Open

Ronald N. Germain, Eliezer M. Van Allen, Gosia Trynka, John S. Tsang, Dominic Grün , et al. · 2024

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) Open

Fayang Zhou, Yuanyuan Zhang, Yuyao Zhu, Qiang Zhou, Yigong Shi , et al. · 2024

Propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC) are biotin-dependent carboxylases (BDCs) that catalyze the metabolism of odd-chain fatty acids, cholesterol, and specific amino acids. For human PCC and MCC, only a…

Structural insights into human exon-defined spliceosome prior to activation Open

Wenyu Zhang, Xiaofeng Zhang, Xiechao Zhan, Rui Bai, Jianlin Lei , et al. · 2024

Spliceosome is often assembled across an exon and undergoes rearrangement to span a neighboring intron. Most states of the intron-defined spliceosome have been structurally characterized. However, the structure of a fully assembled exon-de…

Impact of specific electromagnetic radiation on wakefulness in mice Open

Hu Deng, Lingyu Liu, Xiaping Tang, Yingxian Lu, Xiaofei Wang , et al. · 2024

Electromagnetic radiation (EMR) in the environment, particularly in the microwave range, may constitute a public health concern. Exposure to 2.4 GHz EMR modulated by 100 Hz square pulses was recently reported to markedly increase wakefulne…

Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands Open

Zhifei Wang, Mengying Chen, Qiang Su, Tiago Da Costa Morais, Yan Wang , et al. · 2024

Mutations in the PKD2 gene, which encodes the polycystin-2 (PC2, also called TRPP2) protein, lead to autosomal dominant polycystic kidney disease (ADPKD). As a member of the transient receptor potential (TRP) channel superfamily, PC2 funct…

Dark and Dronc activation in<i>Drosophila melanogaster</i> Open

Lü Tian, Y Li, Yigong Shi · 2024

The onset of apoptosis is characterized by a cascade of caspase activation, where initiator caspases are activated by a multimeric adaptor complex known as the apoptosome. In Drosophila melanogaster , the initiator caspase Dronc undergoes …

Interactions between electromagnetic radiation and biological systems Open

Lingyu Liu, Bing Huang, Yingxian Lu, Yanyu Zhao, Xiaping Tang , et al. · 2024

Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes Open

Sujan Devkota, Rui Zhou, Vaishnavi Nagarajan, Masato Maesako, N. Hung , et al. · 2024

THUMPD2 catalyzes the <i>N2</i>-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration Open

Wenqing Yang, Jianyang Ge, Xiaofeng Zhang, Wenyu Zhu, Lin Lin , et al. · 2024

The mechanisms by which the relatively conserved spliceosome manages the enormously large number of splicing events that occur in humans (∼200 000 versus ∼300 in yeast) are poorly understood. Here, we show deposition of one RNA modificatio…

Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease Open

Xiaotong Wang, Rui Zhou, Xiaqin Sun, Jun Li, Jinxin Wang , et al. · 2023

A hallmark of Alzheimer's disease (AD) is the senile plaque, which contains β‐amyloid peptides (Aβ). Ganglioside GM1 is the most common brain ganglioside. However, the mechanism of GM1 in modulating Aβ processing is rarely known. Aβ levels…

Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes Open

Sujan Devkota, Rui Zhou, Vaishnavi Nagarajan, Masato Maesako, N. Hung , et al. · 2023

Alzheimer’s disease is characterized pathologically by cerebral deposition of 42-residue amyloid β-peptide (Aβ42), proteolytically produced from amyloid precursor protein (APP) by β- and γ-secretases. 1 Although mutations in APP and presen…

Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells Open

Bing Huang, Weihao Zhao, Xue Cai, Yumin Zhu, Yingxian Lu , et al. · 2023

The rapid growth of wireless electronic devices has raised concerns about the harmful effects of leaked electromagnetic radiation (EMR) on human health. Even though numerous studies have been carried out to explore the biological effects o…

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