Yan Shi
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View article: Nephropathogenic infectious bronchitis virus can induce duodenum inflammation and barrier defect in Hy-Line brown chickens
Nephropathogenic infectious bronchitis virus can induce duodenum inflammation and barrier defect in Hy-Line brown chickens Open
View article: Music therapy combined with anesthesia recovery care boosts anesthesia recovery in colorectal cancer patients undergoing laparoscopic radical resection
Music therapy combined with anesthesia recovery care boosts anesthesia recovery in colorectal cancer patients undergoing laparoscopic radical resection Open
BACKGROUND Current standard nursing practices demonstrate limited effectiveness in perioperative colorectal cancer (CRC) management, highlighting the need to explore alternative care strategies that improve clinical outcomes. AIM To invest…
View article: Assessment of modified textbook outcomes following gastrectomy based on survival benefits: a multicenter observational study
Assessment of modified textbook outcomes following gastrectomy based on survival benefits: a multicenter observational study Open
Background Textbook outcome (TO) is an increasingly utilized metric for evaluating perioperative treatment quality. However, a standardized and universally accepted definition of TO in gastrectomy has not yet been established. This multice…
View article: Risk Factors for Poor Matching of Intervertebral Fusion Devices After Posterior Vertebral Column Resection in Patients With Kyphosis or Kyphoscoliosis
Risk Factors for Poor Matching of Intervertebral Fusion Devices After Posterior Vertebral Column Resection in Patients With Kyphosis or Kyphoscoliosis Open
Objectives Numerous studies have reported the manifestations and influencing factors of poor matching of intervertebral fusion devices (IFDs) in patients with cervical and lumbar degenerative diseases. However, there is currently no resear…
View article: Predictive and prognostic value of inflammatory factors (IL-6, IL-8, and TNF-α) in saliva for radiotherapy response in patients with HPV-associated oropharyngeal squamous cell carcinoma
Predictive and prognostic value of inflammatory factors (IL-6, IL-8, and TNF-α) in saliva for radiotherapy response in patients with HPV-associated oropharyngeal squamous cell carcinoma Open
Saliva IL-6, IL-8, and TNF-α are related to radiotherapy sensitivity and prognosis in patients with HPV-associated OPSCC, which can guide the selection of clinical treatment programs.
View article: Development and validation of nomogram for predicting pathological complete response to neoadjuvant chemotherapy and immunotherapy for locally advanced gastric cancer: a multicenter real-world study in China
Development and validation of nomogram for predicting pathological complete response to neoadjuvant chemotherapy and immunotherapy for locally advanced gastric cancer: a multicenter real-world study in China Open
Background The combination of neoadjuvant chemotherapy and immunotherapy (NICT) brings a higher proportion of pathological complete response (pCR) compared with neoadjuvant chemotherapy for locally advanced gastric cancer (LAGC). Here we c…
View article: SocialEval: Evaluating Social Intelligence of Large Language Models
SocialEval: Evaluating Social Intelligence of Large Language Models Open
LLMs exhibit promising Social Intelligence (SI) in modeling human behavior, raising the need to evaluate LLMs' SI and their discrepancy with humans. SI equips humans with interpersonal abilities to behave wisely in navigating social intera…
View article: Crisp: Cognitive Restructuring of Negative Thoughts through Multi-turn Supportive Dialogues
Crisp: Cognitive Restructuring of Negative Thoughts through Multi-turn Supportive Dialogues Open
Cognitive Restructuring (CR) is a psychotherapeutic process aimed at identifying and restructuring an individual's negative thoughts, arising from mental health challenges, into more helpful and positive ones via multi-turn dialogues. Clin…
View article: A causal inference study exploring the impact of iron status on the risk of thyroid cancer based on two-sample mendelian randomization
A causal inference study exploring the impact of iron status on the risk of thyroid cancer based on two-sample mendelian randomization Open
View article: Comment on ‘Impact of Resistance Training and Chicken Intake on Vascular and Muscle Health in Elderly Women’ by Fujie et al.
Comment on ‘Impact of Resistance Training and Chicken Intake on Vascular and Muscle Health in Elderly Women’ by Fujie et al. Open
View article: N6‐Methyladenosine‐Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification
N6‐Methyladenosine‐Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification Open
Lumbar instability causes cartilage endplate ossification and intervertebral disc degeneration. In this study, it is determined that circSMAD4, a Yap1‐related circRNA, is stably downregulated under abnormal stress. In vitro, circSMAD4 knoc…
View article: Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron
Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron Open
Dysregulated alternative splicing has been closely linked to the initiation and progression of tumors. Nevertheless, the precise molecular mechanisms through which splicing factors regulate endometrial cancer progression are still not full…
View article: Gestational Age at Delivery Is an Independent Predictor of Neonatal Outcome for Maternal HELLP Syndrome
Gestational Age at Delivery Is an Independent Predictor of Neonatal Outcome for Maternal HELLP Syndrome Open
Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a severe complication of preeclampsia (PE), with a higher incidence rate in people living at high altitudes, such as Tibet area. Maternal HELLP syndrome is associate…
View article: Crisp: Cognitive Restructuring of Negative Thoughts through Multi-turn Supportive Dialogues
Crisp: Cognitive Restructuring of Negative Thoughts through Multi-turn Supportive Dialogues Open
View article: SocialEval: Evaluating Social Intelligence of Large Language Models
SocialEval: Evaluating Social Intelligence of Large Language Models Open
View article: Nomogram-based prediction of postoperative complications in patients with hypospadias after perididymis covering
Nomogram-based prediction of postoperative complications in patients with hypospadias after perididymis covering Open
Age, length of the formed urethra, types of hypospadias, preoperative penile curvature, and surgical methods are significantly associated with postoperative complications following perididymis covering in patients with hypospadias. These i…
View article: Ergothioneine ameliorates metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) by enhancing autophagy, inhibiting oxidative damage and inflammation
Ergothioneine ameliorates metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) by enhancing autophagy, inhibiting oxidative damage and inflammation Open
View article: Efficacy of a smartphone application assisting home-based rehabilitation and symptom management for patients with lung cancer undergoing video-assisted thoracoscopic lobectomy: a prospective, single-blinded, randomised control trial (POPPER study)
Efficacy of a smartphone application assisting home-based rehabilitation and symptom management for patients with lung cancer undergoing video-assisted thoracoscopic lobectomy: a prospective, single-blinded, randomised control trial (POPPER study) Open
Background: Video-assisted thoracoscopic (VATS) lobectomy can affect patients’ pulmonary function and quality of life significantly. No optimal protocol combining patient-reported outcome-based symptom management and postdischarge rehabili…
View article: Effects of Chronic Cr and Ni Co-Exposure on Liver Inflammation and Autophagy in Mice by Regulating the Tlr4/Mtor Pathway
Effects of Chronic Cr and Ni Co-Exposure on Liver Inflammation and Autophagy in Mice by Regulating the Tlr4/Mtor Pathway Open
View article: Inhibition of SF3B1 improves the immune microenvironment through pyroptosis and synergizes with αPDL1 in ovarian cancer
Inhibition of SF3B1 improves the immune microenvironment through pyroptosis and synergizes with αPDL1 in ovarian cancer Open
View article: EP170/#355 Melk-mediated phosphorylation of RB1 and MAD2L1 promotes chromosomal instability in uterine leiomyosarcoma
EP170/#355 Melk-mediated phosphorylation of RB1 and MAD2L1 promotes chromosomal instability in uterine leiomyosarcoma Open
Introduction This study aimed to investigate the molecular pathogenesis of Uterine Leiomyosarcoma (ULMS), a highly lethal gynecologic malignancy with limited treatment options, and identify potential therapeutic strategies. ULMS is charact…
View article: P1596: EFFICACY AND SAFETY OF QL0911 IN ADULT PATIENTS WITH CHRONIC PRIMARY IMMUNE THROMBOCYTOPENIA: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE III TRIAL
P1596: EFFICACY AND SAFETY OF QL0911 IN ADULT PATIENTS WITH CHRONIC PRIMARY IMMUNE THROMBOCYTOPENIA: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE III TRIAL Open
Topic: 32. Platelet disorders Background: ITP-related national and international guidelines explicitly recommend TPO-RAs as a key option for second-line treatment. QL0911, a recombinant human thrombopoietin mimetic peptide-Fc fusion protei…
View article: [Efficacy of decitabine in patients with glucocorticoid-resistant primary immune thrombocytopenia: factors influencing treatment responses].
[Efficacy of decitabine in patients with glucocorticoid-resistant primary immune thrombocytopenia: factors influencing treatment responses]. Open
Objective: This study aimed to evaluate the efficacy of decitabine (DAC) and identify factors influencing treatment responses in patients with primary immune thrombocytopenia (ITP) who had failed glucocorticoid therapy. Methods:<…
View article: Platelet distribution width and the risk of unexplained recurrent pregnancy loss: a meta-analysis
Platelet distribution width and the risk of unexplained recurrent pregnancy loss: a meta-analysis Open
View article: Multi-omics analysis of molecular landscape and heterogeneity in fetal adenocarcinoma of the lung
Multi-omics analysis of molecular landscape and heterogeneity in fetal adenocarcinoma of the lung Open
Fetal adenocarcinoma of the lung (FLAC) is a rare form of lung adenocarcinoma and was divided into high-grade (H-FLAC) and low-grade (L-FLAC) subtypes. In this study, we first depicted the multi-omics landscapes of this rare lung cancer ty…
View article: Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation
Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation Open
Background Netherton syndrome is a rare, life-threatening autosomal recessive genetic disorder with no effective treatment yet. Skin barrier dysfunction caused by SPINK5 gene mutations is a hallmark of the disease. Antigen penetration thro…
View article: Antioxidative and anti-inflammatory effects of vitamin C on the liver of laying hens under chronic heat stress
Antioxidative and anti-inflammatory effects of vitamin C on the liver of laying hens under chronic heat stress Open
In this study, we investigated the therapeutic effect and mechanism of action of vitamin C on chronic heat stress (CHS)-induced liver oxidative damage and inflammation in laying hens. The thermoneutral control group (TN group) was kept at …
View article: Risk factors for food sensitization in children with atopic dermatitis: a single-center cross-sectional study.
Risk factors for food sensitization in children with atopic dermatitis: a single-center cross-sectional study. Open
The AD children born in autumn or winter, or those with early onset (150 IU/mL have a higher risk of food sensitization. The AD children with food sensitization have a poorer quality of life and are more likely to develop non-specific hand…
View article: Preparation of the RIPK3 Polyclonal Antibody and Its Application in Immunoassays of Nephropathogenic Infectious Bronchitis Virus-Infected Chickens
Preparation of the RIPK3 Polyclonal Antibody and Its Application in Immunoassays of Nephropathogenic Infectious Bronchitis Virus-Infected Chickens Open
Receptor interacting protein kinase 3 (RIPK3) is a vital serine/threonine kinase in regulating the programmed destruction of infected cells to defend against RNA viruses. Although the role of RIPK3 in viruses in mice is well characterized,…
View article: Clinical heterogeneity of NLRP12-associated autoinflammatory diseases
Clinical heterogeneity of NLRP12-associated autoinflammatory diseases Open
Nod-like receptor family pyrin domain-containing protein 12 (NLRP12) is one of the critical pattern recognition receptors which participates in the regulation of multiple inflammatory responses. Mutations in NLRP12 cause exceptional…