Yihang K. Pan
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View article: Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells
Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells Open
Environmental chemicals are known risk factors for adverse pregnancy outcomes. However, the effects of environmentally relevant concentrations of chemical mixtures are less studied. This study investigated the effects of a mixture containi…
View article: Future embracing: exosomes driving a revolutionary approach to the diagnosis and treatment of idiopathic membranous nephropathy
Future embracing: exosomes driving a revolutionary approach to the diagnosis and treatment of idiopathic membranous nephropathy Open
Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults and is associated with high rates of end-stage renal disease. Early detection and precise interventions are crucial for improving patient prognosis and quality …
View article: The control of breathing in fishes – historical perspectives and the path ahead
The control of breathing in fishes – historical perspectives and the path ahead Open
The study of breathing in fishes has featured prominently in Journal of Experimental Biology (JEB), particularly during the latter half of the past century. Indeed, many of the seminal discoveries in this important sub-field of comparative…
View article: Insights into the control and consequences of breathing adjustments in fishes-from larvae to adults
Insights into the control and consequences of breathing adjustments in fishes-from larvae to adults Open
Adjustments of ventilation in fishes to regulate the volume of water flowing over the gills are critically important responses to match branchial gas transfer with metabolic needs and to defend homeostasis during environmental fluctuations…
View article: Catecholamines modulate the hypoxic ventilatory response of larval zebrafish (<i>Danio rerio</i>)
Catecholamines modulate the hypoxic ventilatory response of larval zebrafish (<i>Danio rerio</i>) Open
The hypoxic ventilatory response (HVR) in fish is an important reflex that aids O2 uptake when low environmental O2 levels constrain diffusion. In developing zebrafish (Danio rerio), the acute HVR is multiphasic, consisting of a rapid incr…
View article: Regulation of heart rate following genetic deletion of the ß1 adrenergic receptor in larval zebrafish
Regulation of heart rate following genetic deletion of the ß1 adrenergic receptor in larval zebrafish Open
Aim Although zebrafish are gaining popularity as biomedical models of cardiovascular disease, our understanding of their cardiac control mechanisms is fragmentary. Our goal was to clarify the controversial role of the ß1‐adrenergic recepto…
View article: Aquatic surface respiration improves survival during hypoxia in zebrafish (<i>Danio rerio</i>) lacking hypoxia-inducible factor 1-α
Aquatic surface respiration improves survival during hypoxia in zebrafish (<i>Danio rerio</i>) lacking hypoxia-inducible factor 1-α Open
Hypoxia-inducible factor 1-α (Hif-1α), an important transcription factor regulating cellular responses to reductions in O 2 , previously was shown to improve hypoxia tolerance in zebrafish ( Danio rerio ). Here, we examined the contributio…
View article: Oxygen Chemoreception in Larval Zebrafish: From Signal Initiation to the Hypoxic Ventilatory Response
Oxygen Chemoreception in Larval Zebrafish: From Signal Initiation to the Hypoxic Ventilatory Response Open
Multicellular organisms typically depend on O₂ for energy production to maintain normal cellular function, and even brief periods of O₂ deprivation may have fatal consequences. The aqueous environment is prone to changes in ambient water O…
View article: Evaluating the physiological significance of hypoxic hyperventilation in larval zebrafish (<i>Danio rerio</i>)
Evaluating the physiological significance of hypoxic hyperventilation in larval zebrafish (<i>Danio rerio</i>) Open
In water-breathing fishes, the hypoxic ventilatory response (HVR) represents an increase in water flow over the gills during exposure to lowered ambient O2 levels. The HVR is a critical defense mechanism that serves to delay the negative c…
View article: The Influence of Body Size and Hemoglobin Multiplicity on Critical Oxygen Threshold in Red Drum (Sciaenops ocellatus)
The Influence of Body Size and Hemoglobin Multiplicity on Critical Oxygen Threshold in Red Drum (Sciaenops ocellatus) Open
Hypoxia is common in marine environments and fishes use a suite of cardiorespiratory adjustments to defend aerobic metabolism, including reducing standard metabolic rate (SMR), the minimum metabolic rate needed to sustain life at a specifi…