Yong Gan
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View article: Semi-BSU: A Boundary-Aware Semi-Supervised Semantic Segmentation Framework with Superpixel Refinement for Coastal Aquaculture Pond Extraction from Remote Sensing Images
Semi-BSU: A Boundary-Aware Semi-Supervised Semantic Segmentation Framework with Superpixel Refinement for Coastal Aquaculture Pond Extraction from Remote Sensing Images Open
Accurate segmentation of coastal aquaculture ponds from high-resolution remote sensing images is critical for applications such as coastal environmental monitoring, land use mapping, and infrastructure management. Semi-supervised learning …
View article: CFRANet: Cross-Modal Frequency-Responsive Attention Network for Thermal Power Plant Detection in Multispectral High-Resolution Remote Sensing Images
CFRANet: Cross-Modal Frequency-Responsive Attention Network for Thermal Power Plant Detection in Multispectral High-Resolution Remote Sensing Images Open
Thermal Power Plants (TPPs), as widely used industrial facilities for electricity generation, represent a key task in remote sensing image interpretation. However, detecting TPPs remains a challenging task due to their complex and irregula…
View article: The new era of siRNA therapy: Advances in cancer treatment
The new era of siRNA therapy: Advances in cancer treatment Open
View article: In situ protein corona–camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis
In situ protein corona–camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis Open
Arterial thrombosis is commonly accompanied by poor recanalization and high recurrence, typically caused by a fibrinolysis-resistant microenvironment. We identify elevated levels of plasminogen activator inhibitor–1 (PAI-1) and, notably, i…
View article: Author correction to “The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery” [Acta Pharm Sin B 12 (2022) 1460–1472]
Author correction to “The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery” [Acta Pharm Sin B 12 (2022) 1460–1472] Open
View article: Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply
Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply Open
View article: Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells
Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells Open
This study revealed the co-expression patterns and metabolic pathways between GA-MSCs and GBM, providing new insights into the molecular mechanisms of GBM progression. Targeting FLNC with staurosporine presents a promising therapeutic stra…
View article: Development of a Construction Contract Knowledge Qa Model: A Large Language Model-Based Approach
Development of a Construction Contract Knowledge Qa Model: A Large Language Model-Based Approach Open
View article: High-Precision Magnetic Nanoparticle Thermometry via Analytical Solutions of the Fokker–Planck Equation
High-Precision Magnetic Nanoparticle Thermometry via Analytical Solutions of the Fokker–Planck Equation Open
View article: Development of a Construction Contract Knowledge Qa Model a Large Language Model-Based Approach
Development of a Construction Contract Knowledge Qa Model a Large Language Model-Based Approach Open
View article: Automated Identification of Contract Risk in Construction Projects Based on Large Language Models
Automated Identification of Contract Risk in Construction Projects Based on Large Language Models Open
View article: Automated Identification of Contract Risk in Construction Projects Based on Large Language Models
Automated Identification of Contract Risk in Construction Projects Based on Large Language Models Open
View article: Mapping 10-m Plastic Greenhouses of China Based on Multisource Remote Sensing Products
Mapping 10-m Plastic Greenhouses of China Based on Multisource Remote Sensing Products Open
Plastic greenhouses (PGs), as an important modern agricultural infrastructure, can significantly enhance the crop yield and quality through efficient and intensive production practices. Timely and accurate mapping of PGs is essential for f…
View article: An Image Fusion Algorithm for Sustainable Development Goals Satellite-1 Night-Time Light Images Based on Optimized Image Stretching and Dual-Domain Fusion
An Image Fusion Algorithm for Sustainable Development Goals Satellite-1 Night-Time Light Images Based on Optimized Image Stretching and Dual-Domain Fusion Open
The Glimmer Imager of Urbanization (GIU) on SDGSAT-1 provides high-resolution and global-coverage images of night-time lights (NLs) with 10 m panchromatic (PAN) and 40 m multispectral (MS) imagery. High-resolution 10 m MS NL images after i…
View article: The potential role of <i>Akkermansia muciniphila</i> in liver health.
The potential role of <i>Akkermansia muciniphila</i> in liver health. Open
Akkermansia muciniphila (A. muciniphila) is a 'star strain' that has attracted much attention in recent years. A. muciniphila can effectively regulate host metabolism, significantly affect host immune function, and pla…
View article: Curvature-mediated rapid extravasation and penetration of nanoparticles against interstitial fluid pressure for improved drug delivery
Curvature-mediated rapid extravasation and penetration of nanoparticles against interstitial fluid pressure for improved drug delivery Open
Elevated interstitial fluid pressure (IFP) within pathological tissues (e.g., tumors, obstructed kidneys, and cirrhotic livers) creates a significant hindrance to the transport of nanomedicine, ultimately impairing the therapeutic efficien…
View article: Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy Open
The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum (ER) presents an opportunity to amplify the synergistic effects of chemotherapy and immunotherapy. In this study, we initially validated celastrol (CEL…
View article: Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives
Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives Open
View article: Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery
Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery Open
View article: YCH1899, a Highly Effective Phthalazin-1(2<i>H</i>)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors
YCH1899, a Highly Effective Phthalazin-1(2<i>H</i>)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors Open
Poly(ADP-ribose) polymerase inhibitors (PARPi) have significant efficacy in treating BRCA-deficient cancers, although resistance development remains an unsolved challenge. Herein, a series of phthalazin-1(2H)-one derivatives with ex…
View article: Disturbed Flow‐Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis
Disturbed Flow‐Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis Open
Disturbed blood flow induces endothelial pro‐inflammatory responses that promote atherogenesis. Nanoparticle‐based therapeutics aimed at treating endothelial inflammation in vasculature where disturbed flow occurs may provide a promising a…
View article: Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy
Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy Open
Mutual interference between surface ligands on multifunctional nanoparticles remains a significant obstacle to achieving optimal drug-delivery efficacy. Here, we develop ligand-switchable nanoparticles which resemble viral unique surfaces,…
View article: Virus surface-inspired ligand-switchable nanoparticles enable sequential drug delivery for improved oral insulin therapy
Virus surface-inspired ligand-switchable nanoparticles enable sequential drug delivery for improved oral insulin therapy Open
Mutual interference between surface ligands on multifunctional nanoparticles remains a significant obstacle to achieving the optimal drug-delivery efficacy. Inspired by viruses that modulate surface proteins conformation to enable sequenti…
View article: Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation
Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation Open
Extracellular vesicles (EVs) have been proved a promising small interfering RNA (siRNA) delivery vehicle to mediate gene‐silencing. Tumour‐derived extracellular vesicles (TDEVs) as genetic exchange vectors in the tumour microenvironment, e…
View article: CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity
CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity Open
View article: Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art Open
Mucus is a viscoelastic hydrogel that lubricates and protects mucosal tissues such as the eyes, lung, gastrointestinal tract, and vagina. Nanoparticle-based drug delivery systems (DDSs) can be easily trapped in the mucus network by steric …
View article: The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery
The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery Open
View article: Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel
Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel Open
View article: Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention
Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention Open
Jiangxiu Niu,1,* Ming Yuan,1,* Chenchen Chen,1 Liye Wang,1 Zigui Tang,2 Yanli Fan,1 Xianghui Liu,1 Yu Jiao Ma,1 Yu Gan1 1College of Food and Drug, Luoyang Normal University, Luoyang 471934, People’s Republic of China; 2Department…
View article: MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy
MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy Open
Promoting tumor angiogenesis effectively and specifically to resolve tumor‐associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC‐T‐DOX, is constructed, that ca…