Yi‐Hsuan Chen
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View article: A modeling study of pre-exposure prophylaxis to eliminate HIV in Taiwan by 2030
A modeling study of pre-exposure prophylaxis to eliminate HIV in Taiwan by 2030 Open
View article: Reversed loneliness development after age 65 for men and women: Modeling of the age trajectories of loneliness using national cohorts in Taiwan and Japan
Reversed loneliness development after age 65 for men and women: Modeling of the age trajectories of loneliness using national cohorts in Taiwan and Japan Open
Aim This study depicts the age trajectories of loneliness and gender differences among older adults in Taiwan and Japan. Methods Two nationally representative data sets for older adults in Taiwan and Japan were obtained from the Taiwan Lon…
View article: Using gesture recognition with the memory strategy to improve preschoolers’ learning performance, motor skills, and executive function
Using gesture recognition with the memory strategy to improve preschoolers’ learning performance, motor skills, and executive function Open
Gesture recognition can create an interactive environment in which to train children to control their thoughts, gestures, and body postures when performing learning activities. This study integrated gesture recognition and a memory strateg…
View article: Development of hybrid bonding using area-selective passivation layer deposition technology on various substrates for heterogeneous integrated structure
Development of hybrid bonding using area-selective passivation layer deposition technology on various substrates for heterogeneous integrated structure Open
An advanced area-selective deposition approach for passivation layers in Cu/SiO 2 and Cu/PI hybrid bonding structures is introduced in this study to reduce costs and process complexity compared to traditional PVD passivation. This method i…
View article: Risk factors and mortality of SARS-CoV-2 reinfection during the Omicron era in Taiwan: A nationwide population-based cohort study
Risk factors and mortality of SARS-CoV-2 reinfection during the Omicron era in Taiwan: A nationwide population-based cohort study Open
During the SARS-CoV-2 Omicron era, reinfection patients were observed to have an increased risk of all-cause mortality. To reduce the disease burden and minimize the risk of reinfection, it is crucial for vulnerable patients to receive ful…
View article: Penile squamous cell carcinoma originating from a silicone granuloma
Penile squamous cell carcinoma originating from a silicone granuloma Open
View article: Preexposure Prophylaxis to Eliminate HIV in Taiwan by 2030: A Modeling Study
Preexposure Prophylaxis to Eliminate HIV in Taiwan by 2030: A Modeling Study Open
Preexposure prophylaxis (PrEP) demonstrated 86% efficacy in randomized trials. However, globally, PrEP remains underutilized. The role of PrEP in achieving HIV elimination has been underappreciated and understudied. In Taiwan, the HIV epid…
View article: Achieving COVID-19 zero without lockdown, January 2020 to March 2022: The Taiwan model explained
Achieving COVID-19 zero without lockdown, January 2020 to March 2022: The Taiwan model explained Open
Despite never imposing a lockdown, Taiwan achieved COVID-19 zero, with reporting only 56 local coronavirus disease 2019 (COVID-19) cases after testing 126,987 individuals in 2020, and further contained a large outbreak rapidly and successf…
View article: The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study
The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study Open
Background Tobacco use and secondhand smoke (SHS) are risk factors of kidney stone disease (KSD). The hypothesis is that tobacco produces chemicals that increase oxidative stress and vasopressin, which leads to decreased urine output, and …
View article: Epidemiological characteristics of the three waves of COVID-19 epidemic in Taiwan during April 2022 to March 2023
Epidemiological characteristics of the three waves of COVID-19 epidemic in Taiwan during April 2022 to March 2023 Open
During the three waves of COVID-19 epidemic, the numbers of cases and deaths gradually declined, while the vaccine coverage increased. It may be appropriate to consider easing restrictions and returning to normality. However, continued mon…
View article: High mortality risk of type III monomicrobial gram-negative necrotizing fasciitis: The role of extraintestinal pathogenic Escherichia coli (ExPEC) and Klebsiella pneumoniae
High mortality risk of type III monomicrobial gram-negative necrotizing fasciitis: The role of extraintestinal pathogenic Escherichia coli (ExPEC) and Klebsiella pneumoniae Open
Type III NF, especially cases caused by E. coli or K. pneumoniae, are associated with a comparatively higher mortality risk than type I or type II NF. Wound gram stain-based rapid diagnosis of type III NF may inform empirical antimicrobial…
View article: Effects of Early Pelvic Floor Muscle Training on Early Recovery of Urinary Incontinence after Prostate Surgery
Effects of Early Pelvic Floor Muscle Training on Early Recovery of Urinary Incontinence after Prostate Surgery Open
Purpose: Postprostate surgeries urinary incontinence (UI) is one of the common bothersome complications of prostate surgery. Pelvic floor muscle exercises (PFME) have been reported to have benefits in shortening postoperative recovery time…
View article: Surfactin secreted by Bacillus amyloliquefaciens Ba01 is required to combat Streptomyces scabies causing potato common scab
Surfactin secreted by Bacillus amyloliquefaciens Ba01 is required to combat Streptomyces scabies causing potato common scab Open
Potato common scab, which is mainly caused by the bacterium Streptomyces scabies , occurs in key potato growing regions worldwide. It causes necrotic or corky symptoms on potato tubers and decreases the economic value of potato. At present…
View article: The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study
The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study Open
Background: The aim of this study was to examine the effects of smoking and secondhand smoke (SHS) on the development of kidney stone disease (KSD). Materials and Methods: We analyzed a total of 25,256 volunteers with no history of KSD par…
View article: Da Vinci Xi: a better platform for robotic-assisted radical prostatectomy?
Da Vinci Xi: a better platform for robotic-assisted radical prostatectomy? Open
Background An upgraded surgical robot platform, da Vinci Xi, had demonstrated multiple advantages over the previous da Vinci Si system. Better surgical outcomes had been reported in various operations except for robotic-assisted radical pr…
View article: Efficacy of quaternary ammonium salt-based disinfectant or chelated copper-zinc mixture footbath solution in the control of digital dermatitis in dairy cows
Efficacy of quaternary ammonium salt-based disinfectant or chelated copper-zinc mixture footbath solution in the control of digital dermatitis in dairy cows Open
Background: Bovine digital dermatitis (DD) represents a common cause of lameness in cattle both in Taiwan and worldwide. DD can be controlled using footbaths but the traditional use of footbath with copper sulfate is harmful to the environ…
View article: Pilot Study of Attitudes of Taiwanese Veterinarians and Undergraduate Veterinary Students toward Animal Abuse and Interpersonal Violence
Pilot Study of Attitudes of Taiwanese Veterinarians and Undergraduate Veterinary Students toward Animal Abuse and Interpersonal Violence Open
There is a strong association between animal abuse and interpersonal violence; therefore, veterinarians may encounter both. Dealing with animal abuse cases is beneficial for advancing animal welfare and the overall public health. Veterinar…
View article: Effects of Early Pelvic Floor Muscle Training on Early Recovery of Urinary Incontinence After Prostate Surgery
Effects of Early Pelvic Floor Muscle Training on Early Recovery of Urinary Incontinence After Prostate Surgery Open
Background: Post-prostate surgeries urinary incontinence (UI) is one of the common bothersome complications of prostate surgery. Pelvic floor muscle exercises (PFME) have been reported to have benefits in shortening postoperative recovery …
View article: Factors Related to Psychological Distress in Multiparous Women in the First Trimester: A Cross-Sectional Study
Factors Related to Psychological Distress in Multiparous Women in the First Trimester: A Cross-Sectional Study Open
Background The birth rate in Taiwan has declined rapidly; thus, encouraging women to give birth is an important issue in the country. Pregnant women may experience psychological distress, which may negatively impact the health of children …
View article: Correlation between drug sensitivity profiles of circulating tumour cell-derived organoids and clinical treatment response in patients with pancreatic ductal adenocarcinoma
Correlation between drug sensitivity profiles of circulating tumour cell-derived organoids and clinical treatment response in patients with pancreatic ductal adenocarcinoma Open
CTCs were expanded from patients with PDAC liquid biopsies with a high success rate. Drug sensitivity profiles from CTC-derived organoid cultures correlated meaningfully with treatment response. Further studies are warranted to validate th…
View article: Effect of Doxycycline in Decreasing the Severity of Clostridioides difficile Infection in Mice
Effect of Doxycycline in Decreasing the Severity of Clostridioides difficile Infection in Mice Open
Background: Doxycycline possesses antibacterial activity against Clostridioides difficile and anti-inflammatory effects. Materials and Methods: The influence of doxycycline on the development of CDI was studied in an established animal mod…
View article: Corrigendum: The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients
Corrigendum: The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients Open
[This corrects the article DOI: 10.3389/fimmu.2021.691039.].
View article: Routine HIV Testing and Outcomes: A Population-Based Cohort Study in Taiwan
Routine HIV Testing and Outcomes: A Population-Based Cohort Study in Taiwan Open
Routine HIV testing was associated with highly favorable outcomes, including decreased late diagnosis, lower HIV-related mortality, and lower all-cause mortality, among people diagnosed with HIV infection. Under universal health coverage, …
View article: Correlation Between Drug Sensitivity Profiles of Ex Vivo Expanded Circulating Tumor Cells and Clinical Treatment Response in Pancreatic Ductal Adenocarcinoma Patients
Correlation Between Drug Sensitivity Profiles of Ex Vivo Expanded Circulating Tumor Cells and Clinical Treatment Response in Pancreatic Ductal Adenocarcinoma Patients Open
BackgroundPancreatic ductal adenocarcinoma (PDAC) is highly aggressive and has poor prognosis. There are few biomarkers to inform treatment decisions, and collecting tumor samples for genomic or drug sensitivity testing is challenging.Meth…
View article: Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer’s disease mouse model
Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer’s disease mouse model Open
Although numerous epidemiological studies revealed an association between ambient fine particulate matter (PM 2.5 ) exposure and Alzheimer’s disease (AD), the PM 2.5 -induced neuron toxicity and associated mechanisms were not fully elucida…
View article: Effect of Non-lockdown Social Distancing and Testing-Contact Tracing During a COVID-19 Outbreak in Daegu, South Korea, February to April 2020: A Modeling Study
Effect of Non-lockdown Social Distancing and Testing-Contact Tracing During a COVID-19 Outbreak in Daegu, South Korea, February to April 2020: A Modeling Study Open
View article: The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients
The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients Open
Background Clostridioides difficile is the leading cause of nosocomial infectious diarrhea. Toll-like receptors (TLRs) are the major components of innate immunity that sense pathogens. The relationship between TLRs and C. difficile infecti…
View article: Intrathoracic ureteric stent migration through a reno-pleural fistula: a case report of rare antegrade ureteric stenting complication
Intrathoracic ureteric stent migration through a reno-pleural fistula: a case report of rare antegrade ureteric stenting complication Open
View article: Propylene Glycol Improves Stability of the Anti-Inflammatory Compounds in Scutellaria baicalensis Extract
Propylene Glycol Improves Stability of the Anti-Inflammatory Compounds in Scutellaria baicalensis Extract Open
Scutellaria baicalensis root extracts have been useful for external skin care and have been commercialized for years. Here, a comprehensive study was conducted to investigate the difference between 20% propylene glycol (PG) and water used …
View article: Relationship between renal function and metal exposure of residents living near the No. 6 Naphtha Cracking Complex: A cross-sectional study
Relationship between renal function and metal exposure of residents living near the No. 6 Naphtha Cracking Complex: A cross-sectional study Open
Residents living closer to the petrochemical industry were exposed to higher metal levels and had worse renal function, and the nickel exposure of residents was potentially related to their decline in renal function.