Yi‐Hsuan Tsai
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View article: A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models Open
Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in human cancers. However, inhibitors that block protein-protein inte…
View article: Pre-treatment differential correlation of gene expression and response to topical steroids in eosinophilic esophagitis
Pre-treatment differential correlation of gene expression and response to topical steroids in eosinophilic esophagitis Open
Few predictors of response to topical corticosteroid (tCS) treatment have been identified in eosinophilic esophagitis (EoE). We aimed to determine whether baseline gene expression predicts histologic response to tCS treatment for EoE. We a…
View article: 606 Pharmacodynamic activity of CX-801, a masked IFNα2b PROBODY® cytokine, in patients with advanced melanoma
606 Pharmacodynamic activity of CX-801, a masked IFNα2b PROBODY® cytokine, in patients with advanced melanoma Open
View article: CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition Open
View article: Isolation Methods of Tumor Endothelial Cells Impact AngiomiR Profiles
Isolation Methods of Tumor Endothelial Cells Impact AngiomiR Profiles Open
MicroRNAs (miRNAs) play an important role in endothelial cell growth and differentiation. Tumor angiogenesis-specific miRNAs (angiomiRs) are a subset of miRNAs that are dyregulated in tumor endothelial cells. Because of the importance of a…
View article: The Protective Effects of <scp><i>Lactobacillus reuteri</i></scp> Combined With <scp><i>Clostridium butyricum</i></scp> Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of <scp>5FU</scp>‐Induced Diarrhea
The Protective Effects of <span><i>Lactobacillus reuteri</i></span> Combined With <span><i>Clostridium butyricum</i></span> Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of <span>5FU</span>‐Induced Diarrhea Open
5‐Fluorouracil (5FU) is a commonly employed and highly effective chemotherapeutic agent in clinical oncology. Nevertheless, one of the most frequent and debilitating adverse effects associated with 5FU treatment is diarrhea. These gastroin…
View article: Author Correction: Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins
Author Correction: Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins Open
View article: Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins
Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins Open
View article: Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape
Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape Open
View article: Histone H3 proline 16 hydroxylation regulates mammalian gene expression
Histone H3 proline 16 hydroxylation regulates mammalian gene expression Open
View article: Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors
Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors Open
Transcriptional silencing of HIV in CD4 T cells generates a reservoir of latently infected cells that can reseed infection after interruption of therapy. As such, these cells represent the principal barrier to curing HIV infection, but lit…
View article: Alternative splicing regulation of membrane trafficking genes during myogenesis
Alternative splicing regulation of membrane trafficking genes during myogenesis Open
Alternative splicing transitions occur during organ development, and, in numerous diseases, splicing programs revert to fetal isoform expression. We previously found that extensive splicing changes occur during postnatal mouse heart develo…
View article: RETRACTED: Cheng et al. Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test. Genes 2021, 12, 1539
RETRACTED: Cheng et al. Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test. Genes 2021, 12, 1539 Open
The Genes journal retracts the article “Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test” [...]
View article: Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling
Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling Open
Lung cancer is the leading cause of cancer-related deaths in the world, and non-small cell lung cancer (NSCLC) is the most common subset. We previously found that infiltration of tumor inflammatory monocytes (TIMs) into lung squamous carci…
View article: An integrated model for predicting KRAS dependency
An integrated model for predicting KRAS dependency Open
The clinical approvals of KRAS G12C inhibitors have been a revolutionary advance in precision oncology, but response rates are often modest. To improve patient selection, we developed an integrated model to predict KRAS dependency. By inte…
View article: Figure S3 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S3 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
Multiple Setd2w/f MEF clones display reduced aTubK40me3 protein (A) and relative Setd2 mRNA (B) levels
View article: Figure S5 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S5 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
Reduced SETD2 levels promote genomic instability without compromising H3K36 trimethylation.
View article: Figure S2 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S2 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
SETD2 loss promotes chromosomal abnormalities.
View article: Supplementary Fig Legends from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Supplementary Fig Legends from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
fig legends for sup figures
View article: Data from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Data from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previ…
View article: Supplementary Fig Legends from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Supplementary Fig Legends from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
fig legends for sup figures
View article: Figure S3 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S3 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
Multiple Setd2w/f MEF clones display reduced aTubK40me3 protein (A) and relative Setd2 mRNA (B) levels
View article: Figure S6 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S6 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
Human tumor analysis
View article: Figure S6 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S6 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
Human tumor analysis
View article: Figure S1 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S1 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
Micronuclei are a Common Feature among ccRCC-derived Cell Lines.
View article: Figure S2 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Figure S2 from <i>SETD2</i> Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma Open
SETD2 loss promotes chromosomal abnormalities.
View article: Methylation of nonessential genes in cutaneous melanoma – Rule Out hypothesis
Methylation of nonessential genes in cutaneous melanoma – Rule Out hypothesis Open
Differential methylation plays an important role in melanoma development and is associated with survival, progression and response to treatment. However, the mechanisms by which methylation promotes melanoma development are poorly understo…
View article: Histone H3 proline 16 hydroxylation regulates mammalian gene expression
Histone H3 proline 16 hydroxylation regulates mammalian gene expression Open
View article: Pre-treatment differential correlation of gene expression and response to topical steroids in eosinophilic esophagitis
Pre-treatment differential correlation of gene expression and response to topical steroids in eosinophilic esophagitis Open
Summary Few predictors of response to topical corticosteroid (tCS) treatment have been identified in eosinophilic esophagitis (EoE). We aimed to determine whether baseline gene expression predicts histologic response to tCS treatment for E…
View article: Author Correction: Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins
Author Correction: Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins Open